Gladstone Institutes
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To drive a new era of discovery in disease-oriented science and to mentor tomorrow’s leaders in an inspiring and diverse environment.
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Disrupted Boundary Between Cell Types Linked to Common Heart Defects
Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall.
gladstone.org
February 10, 2026 at 3:15 PM
Read more about this study on our website.
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Careers
Gladstone Institutes leads the way for innovative research in the biomedical field. We always seek dedicated and talented individuals to join our team. Career opportunities are available in both our a...
gladstone.org
February 6, 2026 at 2:23 PM
Find these positions and more on our website: gladstone.org/careers
Administrative Assistant: gladstone.wd503.myworkdayjobs.com/en-US/career...
Administrative Assistant
Category: Administration Lab/Area: GIGI Administration Description: Who we are: The Gladstone Institutes is a leading independent, not-for-profit research organization dedicated to improving human hea...
gladstone.wd503.myworkdayjobs.com
February 6, 2026 at 2:23 PM
Administrative Assistant: gladstone.wd503.myworkdayjobs.com/en-US/career...
Disease-focused Neuroscience and Translational Neurobiology Faculty Position | Gladstone Institutes and UCSF: bit.ly/4qpg6SR
February 6, 2026 at 2:23 PM
Disease-focused Neuroscience and Translational Neurobiology Faculty Position | Gladstone Institutes and UCSF: bit.ly/4qpg6SR
Read more about the new study: gladstone.org/news/disrupt...
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@benoitbruneau.bsky.social
@ucsfanesthesia.bsky.social
@natcardiovascres.nature.com
@irfankathiriya.bsky.social
@benoitbruneau.bsky.social
@ucsfanesthesia.bsky.social
@natcardiovascres.nature.com
Disrupted Boundary Between Cell Types Linked to Common Heart Defects
Gladstone scientists identified a cellular boundary that guides heart development and revealed how disrupting it can lead to holes in the heart’s wall.
gladstone.org
February 2, 2026 at 8:56 PM
Currently, nearly half of all heart defects have no known genetic cause. By uncovering these fundamental biological mechanisms, Gladstone is creating a roadmap to identify new causes and develop therapies that could one day prevent these defects before a child is born.
February 2, 2026 at 8:56 PM
Currently, nearly half of all heart defects have no known genetic cause. By uncovering these fundamental biological mechanisms, Gladstone is creating a roadmap to identify new causes and develop therapies that could one day prevent these defects before a child is born.
In laboratory models, adjusting these molecules partially prevented heart defects from forming. Interestingly, these molecules were previously known for building the brain, and this is the first time they’ve been linked to heart formation.
February 2, 2026 at 8:56 PM
In laboratory models, adjusting these molecules partially prevented heart defects from forming. Interestingly, these molecules were previously known for building the brain, and this is the first time they’ve been linked to heart formation.
While many genes involved in heart defects are difficult to target with medicine, the signaling molecules identified in this study can be targeted.
February 2, 2026 at 8:56 PM
While many genes involved in heart defects are difficult to target with medicine, the signaling molecules identified in this study can be targeted.
The research is driven by deep personal commitment—lead scientist Benoit Bruneau (@benoitbruneau.bsky.social) has studied this for 25 years because his own daughter was born with this type of defect.
February 2, 2026 at 8:56 PM
The research is driven by deep personal commitment—lead scientist Benoit Bruneau (@benoitbruneau.bsky.social) has studied this for 25 years because his own daughter was born with this type of defect.
When the boundary is disrupted, heart cells mix inappropriately, leading to the formation of holes in the heart’s wall.
February 2, 2026 at 8:56 PM
When the boundary is disrupted, heart cells mix inappropriately, leading to the formation of holes in the heart’s wall.
Gladstone researchers identified a thin strip of specialized cells that guide early heart development. Rather than a physical wall, these cells act as a navigation system to ensure different types of heart cells stay in their proper places.
February 2, 2026 at 8:56 PM
Gladstone researchers identified a thin strip of specialized cells that guide early heart development. Rather than a physical wall, these cells act as a navigation system to ensure different types of heart cells stay in their proper places.