France should also not forget to preserve their best minds !

🙏

Un plaisir aussi de voir Elodie Marchal et Laurie Nemoz-Billet jouer avec notre cytométre de déformabilité développé par Jochen Guck et son équipe Martin Kräter #Rivercyte, et Laetitia PAULEN à la paillasse

Un plaisir d'être mis en lumière, ainsi que notre #CRBS @inserm.fr @unistra.fr et sa plateforme #PICSTRA orchestrée par #PascalKessler que nous avons pu labelliser #FBI et #GIS IBiSA (ici Louis Bochler et Zeynep YESILATA devant un de ses microscopes)

💰 Who funded it ?

@inserm.fr
@unistra.fr
Ligue contre le cancer
Institut national du cancer
@fondationarc.bsky.social
@frm-officiel.bsky.social
@fondationdefrance.bsky.social
Cancéropôle Est
Région Grand Est

We received precious help from many collaborators, especially from Jochen Guck and his team including Martin Kräter Salvatore Girardo, but also from Daniel Balzani Daniel J. Müller
@inserm.fr @unistra.fr @maxplanck.de @ethz.ch #UnivBochum @nkinl.bsky.social
#PIC-STRA #CRBS

👩‍🔬 👨‍🔬 Who ?
This study has been initiated many years back in the lab when we realized, as many in the field, that CTCs can also get "stuck" in vessels. It was mostly driven by Valentin Gensbittel, whose wizardy was shaped by many members in the lab (and outside), including @naelosmani.bsky.social

📊 In summary : mechanically adaptable tumor cells are most likely to complete the metastatic cascade

2️⃣ Once arrested, they perform better during #extravasation, by endoctrinating
the endothelium ⚙️ The more viscous, the better
3️⃣ Once extravasated, disseminated cells with low viscosity were better at initiating metastatic outgrowth ⚙️ The more viscous, the better

🔬 What have we found ?
In a nutshell, we show that #tumor #cell #viscosity acts as a rheostat of multiple important steps of hashtag#metastasis.
1️⃣ Circulating tumor cells exploit their viscous properties to reach mechanically-constraining capillaries ⚙️ The less viscous, the better