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gpollara.bsky.social
Gabriele Pollara
@gpollara.bsky.social
9.3K followers 1.6K following 4.6K posts
Infectious Diseases doctor (at UCLH) and academic (at UCL). Research focuses on immune responses to TB and leprosy, but I'm also involved in too many other projects I probably shouldn't be...
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · Nov 21
🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨

We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB.

Lead author @gushamilton.bsky.social

#TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan...
Thread 👇 (1/8)
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Our findings propose a causal relationship between reduced IL-6 signalling and lower risk of tuberculosis, akin to the effect seen in other IL-6 mediated diseases. This study suggests that IL-6 antago...
www.thelancet.com
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 3d
It is soulless and ridiculous.

One day I hope all the players after scoring a goal do the reverse, and all run straight into the manager's technical area, and celebrate only in there! 😅
gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 3d
Congrats!!
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 3d
Yeah was always going to take one match winning performance for those outside the club to sit up and take notice! #CFC
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 3d
Didn't know there were different brands now. Mechanism of action (des cry in these tables) feels quite black box!
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Reposted by Gabriele Pollara
dralicehan.bsky.social
Alice Han @dralicehan.bsky.social · 4d
#IDsky
Bookmark these tables as your quick guide to FMTs!
ppidjournal.bsky.social
PPID Journal @ppidjournal.bsky.social · 5d
#IDsky
Curious about the differences between FMTs for recurrent C. Diff? Which therapy suits your patient best? Explore the 4 options: Rebyota, Vowst, VE303, and CP101 here. www.ppidjournal.com/doi10-55636-...
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 4d
Looking forward 👏
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Gabriele Pollara @gpollara.bsky.social · 5d
Yeah I did wonder if it would affect Pubmed functionality. I suspect it largely runs itself and it is working fine. However you're right we should consider alternatives. Europe PMC works great
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Reposted by Gabriele Pollara
sundermannaj.bsky.social
Alex Sundermann, DrPH @sundermannaj.bsky.social · 5d
Such a wild story!

3 human cases of NDM-CRE likely acquired from their respective pets who likely acquired it from a veterinary hospital outbreak!

Big reason for animal and human cases to be compared

Paper: academic.oup.com/cid/advance-...

#IDSky

Reporting via @cvdall.bsky.social
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Reposted by Gabriele Pollara
drrossanarosa.bsky.social
Rossana Rosa @drrossanarosa.bsky.social · 6d
Excited to back Epipocalypse: Bug Detectives too!! #IDSky
A pledge on Kickstarter for Epipocalypse
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 5d
Good point. I am very happy to ignore / not see popular political content.

Happy it's there for the many that want to follow it, but personally I can't influence it and just stirs needless emotions in an otherwise already busy day!
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 5d
Yes agree. Cost though is a difficult thing to critique, cos the price will never come down unless the technology is implemented more widely. So we need to foremost make a judgement on utility, then the economics will follow. That's just a personal opinion, so I could be wide of the mark.
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 5d
Given how long Elizabeth Line took to build, it may take a while! 😅
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Reposted by Gabriele Pollara
thelancet.com
The Lancet @thelancet.com · 6d
🔔 Introducing The Lancet Regional Health – Africa, a new #goldopenaccess journal promoting the advancement of clinical practice and health policy in Africa.

Explore the new journal at hubs.li/Q03KzMp00 #MedSky
A special preview issue of The Lancet Regional Health – Africa. On the cover is a photograph of a doctor examining a Maasai baby. Copyright: Hugh Sitton/Getty Images
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 5d
Great job @sarasuliman.bsky.social on discussing the evolution of Mycobacterium tuberculosis in human populations over time

#TBSky #IDSky #MedSky 🧪 #genetics

www.nature.com/articles/s41...
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa - Nature Reviews Genetics
Sara Suliman describes a seminal 2013 publication by Comas et al. that investigated the origins of the tuberculosis-causing bacteria and its coevolution with diverse human populations.
www.nature.com
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 6d
Single centre, but evidence for use of metagenomics in clinical practice is building.

Discrpanacy between current gold standard diagnostics is intriguing. Which is the false +ve or -ve result?

Interesting to see if / how impacts clinical practice, including cost-benefit analysis

#IDSky #ClinMicro
lancetmicrobe.bsky.social
The Lancet Microbe @lancetmicrobe.bsky.social · 6d
New research article

Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #OpenAccess #OA
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 6d
somehow an under-reported observation by many news orgs!
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 6d
do you have a link to the Scroll Deep episode?
Reposted by Gabriele Pollara
josephmarcusid.medsky.social
Joseph Marcus @josephmarcusid.medsky.social · 6d
IDWeek 2026 announced: Washington DC

idweek.org/faqs/
When and Where is IDWeek 2026? October 21-24, 2026 Washington, DC
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Reposted by Gabriele Pollara
tbfighters.org
TBFighters @tbfighters.org · 7d
For up to 60% of people cured of TB, treatment isn't the end of the journey. That's why we're thrilled to have @PIH.org's Dr. Carole Mitnick join us for a TB Ed Talk about post-TB lung disease and the pilot intervention she's part of! Learn more and submit questions here: tbfighters.org/tb-ed...
A introduction to Dr. Mitnick's TB Ed Talk and her headshot. "TB Ed Talks LIBRE-Post TB: A Pilot Intervention to Address Post-TB Lung Disease. with Dr. Carole Mitnick Of Harvard Medical School, Partners In Health, and Brigham & Women's Hospital. Live presentation on YouTube followed by a Q&A. Monday, October 27th 8pm ET/5pm PT. Pre-submit questions at the link in the description"
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Reposted by Gabriele Pollara
cmicomms.bsky.social
CMI Communications @cmicomms.bsky.social · 6d
📣 New #Communicable drops Mon 6 Oct! @angelahuttner.bsky.social & @anniejoseph.bsky.social invite experts Melinda Baldwin @mbaldwin.bsky.social & Serge Horbach to discuss the history of peer review, its relevance today & alternative models such as #LLMs.

#IDSky #clinmicro #medsky #peerreview #AI
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 6d
out of curiosity, how is it better?
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Reposted by Gabriele Pollara
dralicehan.bsky.social
Alice Han @dralicehan.bsky.social · 6d
#IDsky
I greatly enjoyed this piece about the Art of the ID Consultation, written by our founding partners at MIDC.

Don’t make the mistakes of Idiot savantism or the Alexander Haig approach! 😂
ppidjournal.bsky.social
PPID Journal @ppidjournal.bsky.social · 6d
#IDsky
Do you know the faux pas of an ID consultation? Don’t make these mistakes!
Here are 8 steps to a successful ID consultation

www.ppidjournal.com/doi10-55636-...
The Art and Science of Infectious Disease Consultation - Private Practice Infectious Disease
Infectious disease is a cognitive specialty, procedurally represented by the consultation. Done correctly, a consultation is a powerful tool that can change physician behavior, strengthen critical relationships,...
www.ppidjournal.com
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Reposted by Gabriele Pollara
jem.org
Journal of Experimental Medicine @jem.org · 7d
Human CD4+ T cells recognize Mycobacterium #tuberculosis–infected #macrophages amid broader responses, say Volodymyr Stetsenko, Daniel P. Gail, Stephen M. Carpenter et al. rupress.org/jem/article/...

#InfectiousDisease #HostDefense #LymphocyteBiology
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Reposted by Gabriele Pollara
gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 7d
Host-directed therapies for infectious disease are here & coming!

Simple equation proposed to consider best interventions:
⭐ Microorganism + immune response = clinical presentation/status ⭐

Will require futuristic-sounding real-time diagnostics = exciting!

#IDSky #MedSky #ImmunoSky #TBSky
The Changing Paradigm in Infectious Diseases - Host-Directed Medicine: Implications for the Next Generation of ID Physicians
academic.oup.com
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gpollara.bsky.social
Gabriele Pollara @gpollara.bsky.social · 6d
Always a fun @nejm.org clinic decision vignetter for team #IDSky / #MedSky!

🤔 Allergy or Assumption of Allergy — When to Test for a Penicillin Allergy? 💭

🌟 Which option would you choose? 🌟

www.nejm.org/doi/full/10....
Allergy or Assumption of Allergy — When to Test for a Penicillin Allergy | NEJM
This feature about a student with strep throat and an unconfirmed penicillin allergy offers a case vignette accompanied by two essays, one supporting use of a nonpenicillin antibiotic and the other...
www.nejm.org
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