Lightnews — Scholar-powered news

Greg Medlock @gregmedlock.bsky.social · 5d

Fully agreed—peptides don’t really overcome any of the policy, payment, or access issues that impede traditional anti-infective commercialization and utility. Cool to have in the armamentarium, but development $$ are mostly a zero sum game in the space…

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Greg Medlock @gregmedlock.bsky.social · 6d

Unfortunately there is a 1000% bollard tariff

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Greg Medlock @gregmedlock.bsky.social · 7d

No mere post can stop the F150s we so adore

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Greg Medlock @gregmedlock.bsky.social · 7d

Knowing the time without a watch

Greg Medlock @gregmedlock.bsky.social · 7d

Things I love about London: BOLLARDS

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Reposted by Greg Medlock

Vaughn Cooper @vscooper.micropopbio.org · 15d

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Faculty Professor Associate - Full-Time | Vaughn Cooper

We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

www.linkedin.com

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Reposted by Greg Medlock

The Onion @theonion.com · 22d

Report: You To Be Fired For Reading This Headline About Charlie Kirk

NEW YORK—Insisting your fate was sealed the moment you clicked the link, a report released Tuesday found that you will be fired for reading this headline about Charlie Kirk. “Shortly after you navigat...

theonion.com

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Reposted by Greg Medlock

Benjamin Wolfe @benwolfe.bsky.social · 22d

Such a delight to share our work on the evolution of a cheese rind fungus in @currentbiology.bsky.social.

This is the fantastic PhD work of @nicolasleonlouw.bsky.social and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more!

🧵

www.cell.com/current-biol...

Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation

Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...

www.cell.com

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Reposted by Greg Medlock

Jim Shaw @jimshaw.bsky.social · Sep 7

Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!

Nanopore's getting accurate, but

1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?

with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social

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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Sep 7

High-resolution metagenome assembly for modern long reads with myloasm https://www.biorxiv.org/content/10.1101/2025.09.05.674543v1

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Reposted by Greg Medlock

Seth Bordenstein @symbionticism.bsky.social · Sep 2

We published a new lane of research today on human gut fungi. Shout out to 1st author @emilyvansyoc.bsky.social sky.social & @erdavenport.bsky.social For 20 years, bacteria received the lion's share of interest in the human gut. Yet we know little about the gut mycobiome. doi.org/10.1371/jour...

Gut fungi are associated with human genetic variation and disease risk

In contrast to decades of research on gut bacteria, human genetic determinants of the gut fungal community (mycobiome) remain understudied. This investigation presents the first GWAS on the number and...

doi.org

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Reposted by Greg Medlock

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · Aug 30

Optimizing storage, high-molecular weight DNA extraction and genome reconstructions from human faecal samples. https://www.biorxiv.org/content/10.1101/2025.08.27.672560v1

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Greg Medlock @gregmedlock.bsky.social · Aug 29

On the very early side, first estimate they provided was 2H 2025-1H 2026.

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Greg Medlock @gregmedlock.bsky.social · Aug 28

Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite

Wonder how frequent this variability in bile acid sensitivity is across bacterial pathogens!

www.cell.com/cell-host-mi...

Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite

Huang et al. identify a multidrug-resistance-associated ABC transporter, CpMRP1, as a genetic determinant of pathogenicity in Cryptosporidium parvum. Through genetic mapping and functional assays, the...

www.cell.com

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Greg Medlock @gregmedlock.bsky.social · Aug 23

Very neat, looking forward to exploring this hypothesis with gut microbes. Nice work @sulheim.bsky.social

Sara Mitri @saramitri.bsky.social · Aug 22

So excited to share this new paper by @sulheim.bsky.social and others! It's rare that you find a pattern, propose a hypothesis and the more you look, the more data you find that fits! Snorre's intuition, hard work and rigour to put it all together have been inspiring! Let us know what you think...

Snorre Sulheim @sulheim.bsky.social · Aug 20

Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social
www.biorxiv.org/content/10.1...

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Reposted by Greg Medlock

Alicia Calvo-Villamañán @aliciapcv.bsky.social · Aug 20

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

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Greg Medlock @gregmedlock.bsky.social · Aug 10

Unusual case of Supplementary table 26 should be figure 2!

Greg Medlock @gregmedlock.bsky.social · Aug 9

Did not know Jibraan joined your group, small world!

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Greg Medlock @gregmedlock.bsky.social · Aug 9

If someone wanted their own custom wrap, where would one go for it?

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Greg Medlock @gregmedlock.bsky.social · Aug 7

Vedanta has an opening for a contract QC analyst. Please share with your network! The ideal candidate will have both micro and molecular biology experience.

job-boards.greenhouse.io/vedantabiosc...

Contract - Quality Control Specialist

Cambridge, MA

job-boards.greenhouse.io

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Reposted by Greg Medlock

STAT @statnews.com · Aug 4

Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.
www.statnews.com/2025/08/04/b...

Gates Foundation pledges $2.5 billion to women’s health initiatives

Breaking: The Gates Foundation said it would commit $2.5 billion through 2030 to support women’s health initiatives, its largest funding commitment ever to the issue.

www.statnews.com

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Reposted by Greg Medlock

Joe Zackular @joeyzacks.bsky.social · Jul 26

Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jul 25

Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1

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Greg Medlock @gregmedlock.bsky.social · Jul 26

📖

Mark Cuban @mcuban.bsky.social · Jul 26

Disintermediating PBMs could save Americans $100b per yr

academic.oup.com/healthaffair...

The cost of misaligned incentives in the pharmaceutical supply chain

Abstract. Recent concerns over rising drug prices have focused on the role of pharmacy benefit managers or PBMs. While multiple players make up the pharmac

academic.oup.com

Reposted by Greg Medlock

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jul 25

Enterococcus faecalis modulates phase variation in Clostridioides difficile https://www.biorxiv.org/content/10.1101/2025.07.24.666506v1

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Greg Medlock @gregmedlock.bsky.social · Jul 23

Lmao

“It pits “neighborly morality” vs. “the ethics of roles.””

The best part is the “gotcha” about their address… info the city collects from people, not the other way around…

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Reposted by Greg Medlock

Casey Theriot @theriotmicrobe.bsky.social · Jul 21

New paper is out from our lab showing that some probiotics can accelerate and prolong the return of colonization resistance to C. difficile after antibiotics.
news.ncsu.edu/2025/07/prob...

Probiotics Can Help or Hinder Gut Recovery After Antibiotic Treatment

news.ncsu.edu

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