Josh Davis
@gurujosh.bsky.social
2.4K followers 680 following 73 posts
Infectious Diseases physician, clinical researcher - clinical trials, SAB, PJI, sepsis, viral hep. CI of SNAP and ROADMAP trials. Runner, Novocastrian, Dad (and thus Dad jokes ++), Chocoholic #IDSky #SNAPtrial
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gurujosh.bsky.social
Big congrats Amy and Richie!
gurujosh.bsky.social
Let me know if your fellows have any questions for the authors!
Reposted by Josh Davis
genevieveemart1.bsky.social
Thrilled to share our new research led by Jane Davies @menziesresearch.bsky.social on First Nations people in the NT living with chronic hepatitis B. An important study that could inform better care:

doi.org/10.1186/s128...

#idsky #MedSky #HepSky #LiverSky
Reposted by Josh Davis
cmicomms.bsky.social
🎙️ Just published a new #Communicable episode: Communicable E28: Late-breaker trials at ESCMID Global: Should they change ...

Hosted by Josh Davis @gurujosh.bsky.social
Erin McCreary @erinmccreary.bsky.social
Emily McDonald @dremilymcd.bsky.social

Listen here:

#IDSky #Clinmicro #MedSky
Communicable E28: Late-breaker trials at ESCMID Global: Should they change your practice? - part 2
Editors of CMI Comms, Josh Davis, Erin McCreary and Emily McDonald...
share.transistor.fm
Reposted by Josh Davis
Reposted by Josh Davis
cmicomms.bsky.social
⏰ Tune in Monday for the latest #Communicable and hear the complete discussion w/ our editors on some of the late breaker trials at #ESCMIDGlobal '25, part 1! 🎙️

@gurujosh.bsky.social @dremilymcd.bsky.social @erinmccreary.bsky.social @marcbonten.bsky.social @escmid.bsky.social

#IDSky #clinmicro
gurujosh.bsky.social
Has been great interacting with >850 orthopods and ID doctors from >50 countries at the www.icmortho.com meeting. Lots of interest in the #ROADMAPtrial!
Reposted by Josh Davis
paulsaxmd.bsky.social
The SNAP trial may finally resolve some of the longest-running debates in SAB management (cefazolin vs semi-synthetic PCN? Is PCN really active vs PSSA?).
Huge congrats to Drs. Joshua Davis, Steven Tong, & the global team who made this ambitious trial happen. #IDSky blogs.jwatch.org/hiv-id-obser...
SNAP Trial Helps Resolve Long-Running Controversies Over Management of Staph Bacteremia
For those who do hospital-based patient care, the significance of Staphylococcus aureus bacteremia (SAB) cannot be overstated. It’s one of the most frequent reasons for infectious disease consultation...
blogs.jwatch.org
gurujosh.bsky.social
Yes. I think it’s mostly because X has mostly (but not completely) died for ID stuff and Bluesky is still not working as well as Twitter did at its peak
gurujosh.bsky.social
Taking a break from talking about #SNAPtrial to work on a new collaboration
#IDSky #ESCMIDglobal
@steventong.bsky.social
gurujosh.bsky.social
Yep me and most people I know will think twice (or thrice) before going to US conferences for the next few years
gurujosh.bsky.social
Alpha toxin at high concentration punches holes in host cells. At lower concentrations it binds to ADAM10 (present in many cell types) and thus indirectly causes cell death
gurujosh.bsky.social
Julianne Wardenberg on S.aureus pathogenesis at #ESCMIDglobal. Alpha toxin is a key virulence factor. First described by Frank Macfarlane Burnet in 1929!
#IDSky
gurujosh.bsky.social
We had not planned but can put this on the to do list!
gurujosh.bsky.social
I had not seen these data before. Is it published?
Reposted by Josh Davis
anniejoseph.bsky.social
And in the big SNAP trial run 🏃‍♀️ for MSSA... it's cefazolin crossing the line ahead of (flu)cloxacillin 🏅

Cefazolin manufacturers are gonna have to really step up after this (still on shortage restrictions in 🇬🇧 😢)

RIP fluclox 🪦

@gurujosh.bsky.social gave an excellent talk 🥁

#ESCMIDGlobal
Reposted by Josh Davis
absteward.bsky.social
The most anticipated RCT in ID
🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia
N:1341
Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia
Cefazolin is non-inferior (90d mortality)& less AKI than ASPs
A practice-changer RCT that must change the guidelines
#ESCMIDGlobal #IDSky
gurujosh.bsky.social
#ESCMIDGlobal year in ID. Sumarry#1
gurujosh.bsky.social
#ESCMIDglobal year in ID Yoav Keynan #IDSky
Paper 6 - REGARD-VAP trial. Short course ABs (3-5 days) versus long course (>=8 days) for VAP in 39 Asian ICUs. No difference in mortality of recurrence, but shorter AB duration and less AEs in short course group.
gurujosh.bsky.social
#ESCMIDglobal year in ID Yoav Keynan #IDSky
Paper 5 - ADAPT sepsis trial
Daily PCT versus daily CRP versus no biomarkers to guide antibiotic cessation. PCT led to decrease in AB duration by 0.88 days. CRP was not useful.
Is 1 day shorter worth it?