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Ben Heineike @heineikeb.bsky.social · Aug 1

Nice new paper by Mariella Obermaier in the Ralser Lab to understand interactions between common drugs co-administered with antifungals and antifungals on C. albicans pubmed.ncbi.nlm.nih.gov/40720257/

Non-antifungal medications administered during fungal infections drive drug tolerance and resistance in Candida albicans - PubMed

<span><b>Introduction.</b> Fungal infections are increasingly concerning, particularly in immunocompromised patients. These patients often suffer from comorbidities and receive multiple, non-antifunga...

pubmed.ncbi.nlm.nih.gov

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Ben Heineike @heineikeb.bsky.social · Jul 25

Nice work by @maxhaase.bsky.social about the strange history of yeast centromeres - got to see him present it at #yeast2025

Max Haase @maxhaase.bsky.social · Apr 25

It’s out! The evolutionary origins of yeast point centromeres uncovered!

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.biorxiv.org/content/10.1...

Ancient co-option of LTR retrotransposons as yeast centromeres

The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

www.biorxiv.org

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Reposted by Ben Heineike

Max Haase @maxhaase.bsky.social · Apr 25

It’s out! The evolutionary origins of yeast point centromeres uncovered!

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.biorxiv.org/content/10.1...

Ancient co-option of LTR retrotransposons as yeast centromeres

The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

www.biorxiv.org

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Ben Heineike @heineikeb.bsky.social · Jul 10

Thanks Jacob for your help with this project- was great working with you!

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Reposted by Ben Heineike

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · Jul 10

NEW pub: The role of metabolism in shaping #enzyme structures over 400 million years. Now out in @nature.com

Super grateful to have played a small role in this project - congrats to lead/corr authors Oliver, Benjamin, and Markus!

www.nature.com/articles/s41...

#alphafold #evolution #genomics

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Ben Heineike @heineikeb.bsky.social · Jul 10

A paper I have been working on with Oliver Lemke in the Ralser lab has just come out: www.nature.com/articles/s41...

We used predicted structures to gain insight into the evolution of metabolic proteins in yeast.

A bit more in this linked-in post (www.linkedin.com/posts/benjam...).

The role of metabolism in shaping enzyme structures over 400 million years - Nature

By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...

www.nature.com

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Reposted by Ben Heineike

liti_nice @litinice.bsky.social · Jul 3

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

Melania D'Angiolo @melaniadangiolo.bsky.social · Jul 3

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.

www.biorxiv.org/content/10.1...

The adaptive molecular landscape of reprogrammed telomeric sequences

Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...

www.biorxiv.org

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Ben Heineike @heineikeb.bsky.social · Mar 22

Wow - amazing mito video!

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