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Heisenberg Lab @heisenbergcplab.bsky.social · 17d

Just back from our group retreat in the beautiful Wachau 🍇! Two days of inspiring scientific presentations on tools and techniques, a fun game night 🐺, and a trip to Rosenburg Castle 🏰 with a breathtaking falconry show 🦅 Here’s to more science and adventures together! 💪✨

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Heisenberg Lab @heisenbergcplab.bsky.social · Sep 8

Ever wondered what happens to developing embryos during hypoxia? 🤔

Find out from our PhD student @k-roksolana.bsky.social at poster #45 at the @embo.org Workshop 'Developmental metabolism: flows of energy, matter & information!' 🐟🧬 #EMBODevMet

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Heisenberg Lab @heisenbergcplab.bsky.social · Aug 24

Heading to Biomatter: From Cytoskeleton to Embryo in Arolla?
Don’t miss our PhD student @prajwal08.bsky.social at poster #44! Come hear about his cool work on #osmoregulation during #embryogenesis.

#Arolla2025

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Heisenberg Lab @heisenbergcplab.bsky.social · Aug 8

Heading to the International Congress on Invertebrate Morphology in Chile? 😄
Don’t miss the talk by our PhD student Alena Kizenko on Aug 12, on how an ancient cytoskeletal gene found a new role in tunicate development 🧬 #EvoDevo #Invertebrates
🎥👇 Developing Phallusia embryo

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Heisenberg Lab @heisenbergcplab.bsky.social · Aug 4

Last week we hosted our annual @hfspo.bsky.social catch up meeting with @paveltomancak.bsky.social, Cassandra Extavour & ‪@hejnol.bsky.social!

Fascinating discussions on the evolutionary functionalization of intermediate filaments shaping animal development 🧬 #EvoDevo

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Heisenberg Lab @heisenbergcplab.bsky.social · Jun 4

Seeing is indeed believing!🧐🤩

Congratulations to our postdoc @tushnakapoor.bsky.social on winning the 'Best Microscopy-based Discovery' prize 🔬,sponsored by @focalplane.bsky.social @biologists.bsky.social,for her talk at the
@embo.org Workshop #EMBOcellpolarity25! 🐟👏🥳

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Heisenberg Lab @heisenbergcplab.bsky.social · May 18

Those of you attending #EMBOcellularmatters, make sure to head to our postdoc @gayasinga.bsky.social' s poster (#47) TOMORROW! Building on insights from Drosophila and Xenopus, she uncovers new mechanisms on how exclusion zones form and persist in 3D #syncytial #embryos in #zebrafish 🐟

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Heisenberg Lab @heisenbergcplab.bsky.social · May 18

Are you attending #EMBOcellPolarity25? Our postdoc @tushnakapoor.bsky.social will talk about her work on how #polarity controls #epiboly movements in #zebrafish, TOMORROW at Session 1, 11:15am! 🐟

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Reposted by Heisenberg Lab

Development @dev-journal.bsky.social · May 15

In preprints: expanded insight into epithelial spreading during zebrafish epiboly

Donna Guan and Ashley Bruce discuss two recent #preprints from Suyash Naik & @heisenbergcplab.bsky.social et al. and Sharon Minsuk & James Glazier et al.:
journals.biologists.com/dev/article/...

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Heisenberg Lab @heisenbergcplab.bsky.social · Apr 16

Congratulations to our postdoc @nikhil-mishra.bsky.social for winning an award for his fantastic talk on 'Zygote geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation' at #DevStem2025 @impvienna.bsky.social! Way to go, Nikhil! 🥳🙌

Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · Apr 6

At the end of #DevStem2025 @viennabiocenter.bsky.social @vbcscitraining.bsky.social, the organizing committee gave out the presentation awards to six happy winners. Many thanks to @gfeev.bsky.social for sponsoring the prizes and the subsequent networking meeting!

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Heisenberg Lab @heisenbergcplab.bsky.social · Mar 14

Woohoo! Work by our former postdoc @stetavano.bsky.social is now published in @cp-cellreports.bsky.social !! 🥳🥳https://tinyurl.com/cjszcphs
Read the summary below to learn more. 👇🐟
Congratulations to all the authors! 👏👏☺️

Ste Tavano @stetavano.bsky.social · Mar 12

That is a great reason for a first post! With a few days of delay, I am proud to share that my postdoc work at the @heisenbergcplab.bsky.social has finally been published on @cp-cellreports.bsky.social doi.org/10.1016/j.ce... Now a small (or maybe not) thread about the work!

Redirecting

doi.org

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Reposted by Heisenberg Lab

Zebrafish Rock! @zebrafishrock.bsky.social · Mar 5

Highlights include the latest works from Bluesky peeps (Bleeps?) @heisenbergcplab.bsky.social & @nikhil-mishra.bsky.social, @vprincelab.bsky.social, @bruceappel.bsky.social, Riddle Lab & @pavaniperera.bsky.social among others! #zebrafish

the Node @the-node.bsky.social · Mar 5

February in preprints

It's time for our monthly trawl for #DevBio and #StemCell biology (and related) #preprints 🔎

Congrats to everyone involved, and as usual, let us know if we've missed anything!

thenode.biologists.com/february-in-...

February in preprints - the Node

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv – use these

thenode.biologists.com

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 28

There’s no age limit to curiosity for #science, science is for everyone! 🤩 Our PhD student Laura Hofmann spoke to senior citizens about her research on Balbiani body in #zebrafish oocytes, & needless to say they were super excited and curious! #Lifelonglearners 👵👴

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 21

Thanks @zebrafishrock.bsky.social! Go read @nikhil-mishra.bsky.social 's preprint on @biorxivpreprint.bsky.social if you still haven't 😉👇
tinyurl.com/Biorxiv-nmis...

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 13

Heisenberg Lab 2025

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 11

Who said Santa arrives only on Christmas Eve? 😏 Sometimes 🎅 comes even in February, like at the Heisenberg lab yesterday 😉 We played Secret Santa, exchanged gifts 🎁 , and ate great food 🍕🍪, to beat the February blues ❄️

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

This work was the result of a fruitful collaboration with Yuting I. Li and @ehannezo.bsky.social.
Also thanks to the support provided by
@istaustria-iof.bsky.social 🔬 and the Aquatics Facility 🐟 @ISTA
Congratulations to all the authors! Excellent work!! 👏👏

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

Finally, the N:C gradient and the resulting gradient of cell cycle length lead to an earlier onset of zygotic transcription at the margin, thereby establishing a novel, ‘symmetry-breaking’ function of early embryo geometry in zygotic transcription onset.

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

… and those with a steeper cell volume gradient due to artificially increased blastodisc curvature show slower propagating waves and decreased synchrony. SM6, SM7

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

Indeed, altering embryo geometry, and therefore the N:C ratio, perturbs the mitotic waves. Embryos with two 'APs' produce two waves, one from each ectopic AP.

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

The N:C ratio becomes graded due to the specific geometry of the early embryo, which causes patterned asymmetric cell divisions, producing smaller daughter cells at the blastoderm margin. This causes greater S-phase lengthening in these marginal cells.

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

Mitotic waves propagate largely independently of cell-cell coupling. In fact, increasing coupling through embryo syncytialization reshapes the wave and causes it to originate at the margin rather than near the AP.

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

We investigated the spatial patterning of early cell cycles in the zebrafish embryo and discovered that a gradient of nucleocytoplasmic (N:C) ratio within the embryo spatially patterns S-phase length along the animal pole (AP)-margin axis, producing radial mitotic waves near the AP.

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 6

📢‼️ Exciting new preprint from the lab by @nikhil-mishra.bsky.social et al, now out on @biorxivpreprint.bsky.social, reveals that the early embryo geometry spatiotemporally patterns zygotic genome activation (ZGA) in zebrafish. 🐟 tinyurl.com/Biorxiv-nmis...

Read on to learn more... 👇

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Heisenberg Lab @heisenbergcplab.bsky.social · Feb 5

The Heisenberg Lab is now on Bluesky! Follow our account to learn about our latest work, lab news, and more. #zebrafish, #ascidian #drosophila #development #mechanics

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