Excellent thesis defense by Pinki Gahlot concluding brillant work on a sensor module, SPG20-ITCH that detects lipid packing defects in the limiting membrane of permeabilized #lysosomes and initiates #lysophagy.

ATXN3-p97 facilitates #lysosomal restoration after damage by deubiquitinating LAMP2 and targeting it for degradation via microautophagy
Hemmo Meyer and coworkers @hemmo-lab.bsky.social
www.embopress.org/doi/full/10....

Fun at the lab outing

A successful @crc1430.bsky.social PhD Career Day is behind us!
Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights.
We enjoyed a day full of career advice, inspiring talks, and great networking over dinner.
#PhDCareers #JobsAfterPhD

Thank you again Chuna Choudhary from @choudharylabcpr.bsky.social at CPR in Copenhagen for visiting us last week for an exiting CRC1430 @crc1430.bsky.social seminar and for discussing the systems properties of ubiquitination www.cell.com/cell/fulltex...

We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin

Concluding a productive @crc1430.bsky.social retreat with our PIs, exploring the 'Molecular Mechanisms of Cell State Transitions'. Thanks to everyone for the engaging discussions and collaborative efforts that made this retreat truly impactful! #ScienceInAction #ResearchCollaboration

Can’t believe the fantastic Dana Branzei has joined our faculty in Essen and the #CRC1430! Esteemed expert in DNA replication and repair, Humboldt-Professor, and zabaione connaisseuse. #UDE

Another excellent Frankfurt meeting #fcqc2025 on cellular quality control. Fantastic speaker lineup, discussions and hospitality. Thx to the organizers. #ubiquitin #autophagy fcqc.de

Great visit in Kiel Biochemistry with Elmar Wolf, Paul Saftig, M. Damme, M. Voß. Talking exciting (lysosome) science at the beautiful Kiel Fjord.

New VCP/p97 review article. Report on the excellent VCP meeting at CalTech last year and great overview on VCP and VCP disease.
doi.org/10.1016/j.nb...

Different ways to target substrate proteins to the VCP/p97 unfolding machine: www.frontiersin.org/journals/mol...

Our review on the lysosomal damage response is Open Access: www.annualreviews.org/content/jour...