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Reposted by Hennig-Lab

SPC Facility & Garcia-Alai Lab @spcembl.bsky.social · Sep 8

Congrats to the Grünewald, Topf groups & et. al @cssbhamburg.bsky.social on their Nature paper! 📃 🍾

Trapping and resolving the elusive prefusion form of HSV gB - neutralizing HSV-1 & HSV-2 with a single nanobody is no small feat!🦙

Glad that our SPC facility have contributed to this [email protected]

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Anna Leder @annaleder.bsky.social · Aug 11

Happy to share my first publication, where we present our discovery of multi-chaperone condensates that orchestrate protein folding in the endoplasmic reticulum!
www.nature.com/articles/s41...

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Martin Pacesa @martinpacesa.bsky.social · Aug 7

"Hey Bob, just dock the AF3 prediction into density and deposit"

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Hennig-Lab @hennig-lab.bsky.social · Jul 29

With Instagram-ready spike ball pictures (pay attention to the sun beam! 😇).

Hennig-Lab @hennig-lab.bsky.social · Jul 29

Instagram-ready group picture from our lab hike

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Hennig-Lab @hennig-lab.bsky.social · Jul 11

Indeed!

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Hennig-Lab @hennig-lab.bsky.social · Jul 11

The most expensive bike stand in the world! 😢

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Hennig-Lab @hennig-lab.bsky.social · Jun 28

If you are interested in cellular RNA transport, check out Simone Heber's first corresponding author paper: www.cell.com/cell-reports...
Very cool stuff about motor switching to get the transport direction right. Collaboration between the Ephrussi, Niessing. Hennig, Chao and Heber groups.

A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C in the oskar mRNA transport complex

Gaber et al. identify a direct protein-protein interaction between the oskar mRNA transport particle components Staufen and Tropomyosin1-I/C. They map the interaction surface at amino acid resolution ...

www.cell.com

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Michael Jendrusch @mjendrusch.bsky.social · Jun 26

Happy to see @embl.org highlight our work on protein design at Korbel group with @typaslab.bsky.social and @hennig-lab.bsky.social !
Working with everyone was a blast and helping to bring our software to production at DenovAI was quite the exciting experience.

EMBL @embl.org · Jun 23

EMBL researchers have developed a new AI framework – AlphaDesign – which can design new proteins that might have therapeutic benefits.

Using AlphaDesign, the researchers succeeded in creating synthetic inhibitors for a bacterial phage defence system.

www.embopress.org/doi/full/10....

The EMBL scientists who developed AlphaDesign. From left to right: Michael Jendrusch, Kashif Sadiq, Jan Korbel. Credit: Kinga Siring/EMBL

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Michael Jendrusch @mjendrusch.bsky.social · Jun 19

Happy to announce the first paper from my PhD at Korbel group at @embl.org has finally been published:
embopress.org/doi/full/10.1038…
Collaborating with @typaslab.bsky.social, @hennig-lab.bsky.social and the EMBL PEPCF, we designed de novo inhibitors to a bacterial phage defense system 1/🧵

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Hennig-Lab @hennig-lab.bsky.social · Jun 17

Check it out if you are interested in designing your own protein binders to any protein target. It works (see example in the article).

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Hennig-Lab @hennig-lab.bsky.social · Jun 17

New publication by the Korbel group @embl.org. Very cool new protein design pipeline. We just validated some of the designs for them by NMR . See below for more.
AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology www.embopress.org/doi/full/10....

AlphaDesign: a de novo protein design framework based on AlphaFold | Molecular Systems Biology

imageimageAlphaDesign combines hallucination and sequence generation to design various classes of proteins, from monomers to oligomers and site-specific binders. AlphaDesign was applied to design in v...

www.embopress.org

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Hennig-Lab @hennig-lab.bsky.social · Jun 16

We did it in 8:43 h! A great team and leaders. So much fun. Thanks to everyone who has donated 😍! If you still want to donate it is possible until this Friday (20th of June): egeninsamling.brostcancerforbundet.se/fundraisers/...

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Hennig-Lab @hennig-lab.bsky.social · Jun 16

Last Saturday I rode the Vätternrundan with the charity organization "I move for cancer" to raise money for breast cancer research. The goal was to finish the ride of 315 km around beautiful lake Vättern faster than 9 h.

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Hennig-Lab @hennig-lab.bsky.social · Jun 6

Billionaires are attacking our rights, our media, and our freedom. It’s time to resist. I just signed this petition—add your name and be part of the movement: act.gp/3Rqfnlz #TimeToResist

Think corporate elites should not control our rights and freedom? Sign - Greenpeace International

Billionaires and corporations are tightening their grip on our democracies — and silencing dissent. They weaken protections for people and the planet, bankroll politicians who serve their interests, c...

act.gp

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Hennig-Lab @hennig-lab.bsky.social · May 28

If you are inclined to support cancer research, check this out and donate. You also keep me motivated 😁: egeninsamling.brostcancerforbundet.se/fundraisers/...

Vätternrundan 315 km under 9:00 h with IMFC: 14th of June 2025

The goal is to finish one of the biggest bike events of the world in under 9:00 h (315 km, average riding speed 37 km/h, on the 14th of June 2025), while supporting cancer research (specifically breas...

egeninsamling.brostcancerforbundet.se

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Olivier Duss @olivierduss.bsky.social · Apr 29

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs!
www.biorxiv.org/content/10.1...

Single-molecule multimodal timing of in vivo mRNA synthesis

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

www.biorxiv.org

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Saganism @sagan.bsky.social · Apr 26

“We've arranged a society based on science and technology, in which nobody understands anything about science and technology. And this combustible mixture of ignorance and power, sooner or later, is going to blow up in our faces.”

~ Carl Sagan

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Apr 21

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

www.biorxiv.org

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Carl Zimmer @carlzimmer.com · Apr 16

120 light years from Earth, there's a planet that may be covered in a living ocean. Here's my story on a tantalizing hint of life beyond the Solar System. Gift link: nyti.ms/3GbrEaZ 🧪

Astronomers Detect a Signature of Life on a Distant Planet (Gift Article)

Further studies are needed to determine whether K2-18b, which orbits a star 120 light-years away, is inhabited, or even habitable.

nyti.ms

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Katie Mack @astrokatie.com · Apr 17

Looks like the evidence for this weird chemical abundance in an exoplanet atmosphere has gotten stronger with new JWST data: www.nytimes.com/2025/04/16/s...

Is it really a sign of life? That’s still not clear; lots of analysis left to do. But it’ll be interesting to see how it all pans out! 🧪 🔭

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Olivier Duss @olivierduss.bsky.social · Apr 12

Ever wondered how several individual RBPs cooperate to repress translation?

Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time!

www.biorxiv.org/content/10.1...

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Sergio Cruz-León @sergiocruzleon.bsky.social · Apr 11

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social

🔗 Preprint here tinyurl.com/3a74uanv

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Hennig-Lab @hennig-lab.bsky.social · Apr 11

🧵 8/8 Combining different methodologies (smFRET, NMR, reporter gene assays) we developed a framework that can now be used to study similar processes in other biological systems! 🧬 #single-molecule #FRET #RNA #translation #Biophysics

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Hennig-Lab @hennig-lab.bsky.social · Apr 11

🧵 7/8 Why this matters: Understanding these molecular mechanisms helps us grasp how cells regulate their genes through different complex assembly mechanisms