Lightnews — Scholar-powered news

Reposted by HKD-lab

Institut Imagine @institutimagine.bsky.social · Sep 4

Open call for applications for the International PhD PPU-IMAGINE program!

Don’t miss out on 16 different PhD research projects at Institut Imagine!

Deadline: October 20, 2025

For more information: www.institutimagine.org/en/internati...

1 6 8

HKD-lab @hkd-l.bsky.social · Jun 27

New interesting paper on MAPKBP1, which sheds new light on its localization and function at #cilia! Many thanks to Ria and Jan for inviting us to participate in this exciting work! Congratulations to all collaborators!
#ciliopathies #kidney #nephronophthisis

www.kireports.org/article/S246...

Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Signaling in MAPKBP1-Associated Kidney Disease

Nephronophthisis (NPH) is a renal ciliopathy characterized by chronic tubulointerstitial fibrosis. Despite discovery of multiple disease genes, mechanisms of NPH-associated kidney degeneration remain ...

www.kireports.org

2 2

Reposted by HKD-lab

Hassan Saei @hassansaei.bsky.social · Jun 16

🚨 Our new preprint is out!
We developed kidney organoid models of X-linked Alport syndrome carrying deep-intronic variants. Through in-depth characterization, we demonstrate their potential as a robust platform for individualized splice-switching therapy development. #Alport #ASO
@hkd-l.bsky.social

bioRxiv Genetics @biorxiv-genetic.bsky.social · Jun 12

Therapeutic splice modulation of COL4A5 reinstates collagen IV assembly in an organoid model of X-linked Alport syndrome https://www.biorxiv.org/content/10.1101/2025.06.10.658776v1

2 3

HKD-lab @hkd-l.bsky.social · May 15

Congratulations to Giulia and Amandine, to other members of the lab and collaborators! Their last paper on IL1-beta in Nephronophthisis is now out in Genes & diseases. #ciliopathies #kidney #inflammation

www.sciencedirect.com/science/arti...

IL1β is induced in nephronophthisis but does not mediate kidney damage

www.sciencedirect.com

1 2

HKD-lab @hkd-l.bsky.social · May 7

Our last paper is now available on the Kidney International website! Thanks to all collaborators and special congrats to Alice and Guillaume... #cilia #ciliopathies #kidney

www.sciencedirect.com/science/arti...

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis

Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development …

www.sciencedirect.com

1 1

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Apr 17

9 PhD positions to work on #cilia and #ciliopathies including 2 in our lab @hkd-l.bsky.social @institutimagine.bsky.social

www.cilia-ai.eu

Cilia-AI

www.cilia-ai.eu

2 1

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Mar 15

Here is a recent paper by colleagues from @hopitalnecker.bsky.social and @institutimagine.bsky.social showing that loss of IFT27 lead to fetal #ciliopathies with #cilia defects in #kidney

www.nature.com/articles/s41...

Complete loss of IFT27 function leads to a phenotypic spectrum of fetal lethal ciliopathy associated with altered ciliogenesis - European Journal of Human Genetics

European Journal of Human Genetics - Complete loss of IFT27 function leads to a phenotypic spectrum of fetal lethal ciliopathy associated with altered ciliogenesis

www.nature.com

3 3

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Mar 5

Last from the archives, scanning #electronmicroscopy pictures of #cilia in #kidney IMCD3 cells (no triton) by Rania and Thierry from @bastinlab.bsky.social.
The longest straight cilium ever and two interacting ones!

2 9

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Mar 1

Explicit content… demembraned n.k.d #cilia !!!
Other examples of scanning #electronmicroscopy of triton-treated IMCD3 #kidney cells with @bastinlab.bsky.social - see also previous post.

1 3 14

HKD-lab @hkd-l.bsky.social · Feb 25

Two PhD positions in our lab for two different projects on #ciliopathies and #cilia

Alexandre Benmerah @alexbnmrh.bsky.social · Feb 21

Two positions available in our lab!

HKD-lab @hkd-l.bsky.social · Jan 17

We are hiring!
As part of the EU-funded Marie Skłodowska-Curie Action training network "Cilia-AI" we have two fully funded PhD positions available in our group in Paris @institutimagine.bsky.social

For more information:
www.cilia-ai.eu
www.institutimagine.org/en/sophie-sa...

1

Reposted by HKD-lab

PKD Foundation @pkdfoundation.bsky.social · Feb 18

Welcome to the PKD Foundation’s Bluesky! We’re proud to be the only organization in the U.S. solely dedicated to finding treatments and a cure for polycystic kidney disease (PKD). Learn more about our organization at pkdcure.org.

4 7

HKD-lab @hkd-l.bsky.social · Feb 19

Not just you Bernhard ;) ... Cheers, Alex

Reposted by HKD-lab

Alessandra Boletta @bolettalab.bsky.social · Feb 11

Congratulations to Max Liebau 👏 and colleagues for a breakthrough study defining a risk score to predict kidney survival in ARPKD patients 👏 pubmed.ncbi.nlm.nih.gov/39922379/

A risk score to predict kidney survival in patients with autosomal recessive polycystic kidney disease at the age of two months - PubMed

Autosomal recessive polycystic kidney disease (ARPKD) is a severe hepatorenal fibrocystic disorder. Its rareness and the variability of disease courses have been major obstacles for the establishment ...

pubmed.ncbi.nlm.nih.gov

1 12

Reposted by HKD-lab

Hassan Saei @hassansaei.bsky.social · Feb 6

🚨Check out our latest paper in AJKD! We highlighted the importance of unbiased and large-scale genetic testing in ADTKD-MUC1.

Using VNtyper, we identified de novo cases and ADTKD was not initially suspected in ~40% of positive cases in our cohort.

#ADTKD #MUC1 #VNtyper

American Journal of Kidney Diseases @ajkd.bsky.social · Feb 6

Phenotypic Heterogeneity of ADTKD-MUC1 Diagnosed Using VNtyper, a Novel Genetic Technique

https://bit.ly/4glVIxd

#ADTKD #CKD

3 7

HKD-lab @hkd-l.bsky.social · Jan 28

Next meeting of the French #cilia and #ciliopathies network!

club CFC @club-cfc.bsky.social · Jan 28

First announcement for the next CFC meeting which will be organized by Séverine Bär, Sylvie Friant and Hélène Dollfus with colleagues from the #cilia and #centrosome workgroup of the German Society for Cell Biology. It will take place from October 13th to 15th 2025 in Oberbronn near Strasbourg.

HKD-lab @hkd-l.bsky.social · Jan 24

Last publication from the HKD-lab...
Special congratulations to Jessica and @hassansaei.bsky.social as well as to all collaborators!
#kidney #ADTKD #MUC1

www.sciencedirect.com/science/arti...

Phenotypic Heterogeneity of ADTKD-MUC1 Diagnosed Using VNtyper, a Novel Genetic Technique

Molecular diagnosis of autosomal dominant tubulointerstitial kidney disease (ADTKD) due to variants in the MUC1 gene has long been challenging since v…

www.sciencedirect.com

3 4

HKD-lab @hkd-l.bsky.social · Jan 23

It was a very stimulating scientific afternoon yesterday @institutimagine.bsky.social !
Congratulations to Joran from our lab for his great presentation!

Alexandre Benmerah @alexbnmrh.bsky.social · Jan 23

I was very happy to welcome the first 2025 meeting of the French #cilia network @institutimagine.bsky.social!
It was a great afternoon, thanks again to all the speakers and Amandine @hkd-l.bsky.social for her help! See you in Strasbourg in October for the next one!
#ciliopathies #flagella

4

HKD-lab @hkd-l.bsky.social · Jan 20

The new preprint from the lab is now available on #biorxiv! It was a team effort led by @alexbnmrh.bsky.social and Alice Tata and funded by #ANR (RHU C'IL-LICO) and European commission (SCILS, TheRaCil) @institutimagine.bsky.social
#kidney #cilia #ciliopathies

www.biorxiv.org/content/10.1...

Evaluation of Prostaglandin Receptor Agonists and Eupatilin in the Context of Nephronophthisis

Background Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development and in response to environmental stimul...

www.biorxiv.org

HKD-lab @hkd-l.bsky.social · Jan 17

We are hiring!
As part of the EU-funded Marie Skłodowska-Curie Action training network "Cilia-AI" we have two fully funded PhD positions available in our group in Paris @institutimagine.bsky.social

For more information:
www.cilia-ai.eu
www.institutimagine.org/en/sophie-sa...

2 2

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Jan 13

14 PhD Positions in the Cilia-AI Consortium!

Cilia-AI is a European training rogramme for deconvolution of multi-scale cilia function in health and disease by integrating machine learning-AI approaches.

www.cilia-ai.eu

Cilia-AI

www.cilia-ai.eu

2 6

Reposted by HKD-lab

Alexandre Benmerah @alexbnmrh.bsky.social · Jan 16

Hello everyone, our last work is now available on #biorxiv !
Thanks to all collaborators, platforms of the Necker/Imagine campus and patient families.

www.biorxiv.org/content/10.1...

Evaluation of Prostaglandin Receptor Agonists and Eupatilin in the Context of Nephronophthisis

Background: Primary cilia are sensory antennas that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development and in response to environmental stimu...

www.biorxiv.org

2 3