“The goal isn’t just to live longer, it’s to live better.”
— Ezekiel Emanuel
New Health & Veritas bonus episode 🎙️
insights.som.yale.edu/podcasts/hea...

“If wellness requires constant self-denial, it won’t last.”
— Ezekiel Emanuel
Why eating your ice cream might actually be part of a healthy life.
🎧 Health & Veritas bonus episode
insights.som.yale.edu/podcasts/hea...

“Having friends is better for your immune system and your heart than most people realize.”
— Ezekiel Emanuel
Bonus episode of Health & Veritas 🎙️
🎧 insights.som.yale.edu/podcasts/hea...

“Wellness shouldn’t feel like self-denial.”
— Ezekiel Emanuel
A bonus episode of Health & Veritas on longevity, joy, and what the evidence really says.
🎧 insights.som.yale.edu/podcasts/hea...

And be sure to check out our Adipokine Explorer!

www.jacc.org/jacc/interac...

Here is my substack on the topic: Fat, Reframed.

neverdelegateunderstanding.substack.com/p/fat-reframed

@jaccjournals.bsky.social is the place for ideas that may change our thinking; spark dialogue; and contribute to progress in advancing global cardiovascular health.

HFpEF is one of medicine’s biggest puzzles.

Maybe the answers lie not in the heart alone, but in the cross-talk between fat and myocardium.

Read the full JACC Adipokine Spotlight and join the conversation.

🔗 www.jacc.org/toc/jacc/cur...

#JACC #HFpEF #Cardiology #AdipokineHypothesis

The issue invites disagreement and testing.

Some cases of HFpEF may not fit the model.

But frameworks like this push the field forward—helping us ask sharper questions and design better studies.

Themes emerge:

• It’s about fat distribution, not just BMI.

• Adipokines act through endocrine-paracrine signaling.

• Sex, race, and metabolic context all shape expression and risk.

• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.

To deepen the discussion, we invited experts across cardiology and metabolism to weigh in:

• Erica Spatz: A Turning Point

• Carolyn Lam & Dalane Kitzman: From Pariah to Paradigm

• Subodh Verma & Deepak Bhatt: Parsing the Adipokine Axis

• Faiez Zannad, Jennifer Ho, Robert Mentz, and others.

As Editor-in-Chief, I wrote about why JACC published it:
Because progress in medicine requires ideas that connect disciplines and challenge assumptions.

🧠 “Ideas Worth Testing: The Adipokine Hypothesis.”

www.jacc.org/doi/10.1016/...

In this 25,000-word State-of-the-Art Review, Packer unites >1,800 references to build a testable framework explaining how dysfunctional adipose tissue could underlie HFpEF.

It’s bold, ambitious—and worth debating.

Dr. Milton Packer proposes that hypertrophied, inflamed fat cells secrete molecules—adipokines—that drive cardiac remodeling, inflammation, and fibrosis.

In other words: HFpEF may begin in fat, not the heart.