hopfnerlab.bsky.social
Hopfner Lab
@hopfnerlab.bsky.social
330 followers 140 following 6 posts
Structural biology on DNA repair, chromatin remodelling and innate immunity. Located at the Gene Center of the LMU in Munich. https://www.genzentrum.uni-muenchen.de/research-groups/hopfner/index.html
www.genzentrum.uni-muenchen.de
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · 19d
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · 19d
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP

We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · Aug 27
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
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Reposted by Hopfner Lab
sfb1361.bsky.social
SFB1361 @sfb1361.bsky.social · Aug 7
We‘re proud to share that our #SFB1361 PhD student, Yilan Fan from the @hopfnerlab.bsky.social, has been awarded a poster prize at the CNIO-CaixaResearch Frontiers Meeting “Machines on DNA and RNA: A Molecular Mechanistic Perspective“ held on 28-30 May 2025 in Madrid, Spain.
Congrats! 🎉
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · Aug 27
Check out our pre-print on how the human INO80 complex acts on nucleosomes and hexasomes: PostDocs Priyanka & Manmohan et al. solved structures of INO80 bound to several substrates and completed missing questions about similarities of modes of actions across species🧬 www.biorxiv.org/content/10.1...
Recognition and remodelling of nucleosomes and hexasomes by the human INO80 complex
The ATP-dependent INO80 chromatin remodeller slides and repositions nucleosomes to shape and maintain chromatin around gene regulatory elements and replication origins. Recent work uncovered capabilit...
www.biorxiv.org
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Reposted by Hopfner Lab
jstingele.bsky.social
Julian Stingele @jstingele.bsky.social · Jul 21
Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · Mar 17
Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...
Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex
The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...
www.biorxiv.org
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · Dec 3
Congratulations to our SLFN team - @michaelkugler.bsky.social, Felix Metzner and Katja Lammens for uncovering yet another intricate mechanism! Special thanks to Gregor Witte for his contribution! #innateimmunity #cryoEM #structuralbiology
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hopfnerlab.bsky.social
Hopfner Lab @hopfnerlab.bsky.social · Dec 3
Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.

Check out our new paper here www.nature.com/articles/s41... + movie
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