Stephan Huveneers
@huveneerslab.bsky.social
Associate Professor at Amsterdam UMC, University of Amsterdam / Vascular Biology / Mechanotransduction / Junctions / Adhesion / Cell migration / Angiogenesis / Atherosclerosis / Capillary malformations
/ https://www.medicalbiochemistry.nl/stephan-huveneers
/ https://www.medicalbiochemistry.nl/stephan-huveneers
With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
February 4, 2026 at 9:41 PM
With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
The article also includes a full phosphoproteomic dataset, provided as open-source data, mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. www.ebi.ac.uk/pride/archiv...
PRIDE - PRoteomics IDEntifications Database
EMBL-EBI
www.ebi.ac.uk
February 4, 2026 at 9:41 PM
The article also includes a full phosphoproteomic dataset, provided as open-source data, mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. www.ebi.ac.uk/pride/archiv...
The study shows:
• How the Gαq-R183Q mutation in endothelial cells disrupts normal signaling, impairing cell migration and angiogenic sprouting
• That DSCR1.4 is a key mediator of these effects
• That inhibition of Calcineurin with Tacrolimus or depletion of DSCR1.4 can restore endothelial function
• How the Gαq-R183Q mutation in endothelial cells disrupts normal signaling, impairing cell migration and angiogenic sprouting
• That DSCR1.4 is a key mediator of these effects
• That inhibition of Calcineurin with Tacrolimus or depletion of DSCR1.4 can restore endothelial function
February 4, 2026 at 9:41 PM
The study shows:
• How the Gαq-R183Q mutation in endothelial cells disrupts normal signaling, impairing cell migration and angiogenic sprouting
• That DSCR1.4 is a key mediator of these effects
• That inhibition of Calcineurin with Tacrolimus or depletion of DSCR1.4 can restore endothelial function
• How the Gαq-R183Q mutation in endothelial cells disrupts normal signaling, impairing cell migration and angiogenic sprouting
• That DSCR1.4 is a key mediator of these effects
• That inhibition of Calcineurin with Tacrolimus or depletion of DSCR1.4 can restore endothelial function
Wednesdand and Thursday its time for our poster at the #GRC Directed Cell Migration conference: will be highlighting new trafficking mechanisms at asymmetric adherens junctions. Drop by if you’re interested!
January 14, 2025 at 11:32 AM
Wednesdand and Thursday its time for our poster at the #GRC Directed Cell Migration conference: will be highlighting new trafficking mechanisms at asymmetric adherens junctions. Drop by if you’re interested!