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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 1d

Early findings from @pennmedicine.bsky.social and @cincychildrens.bsky.social suggest a new vaccine may prevent allergens from triggering harmful immune reactions and inflammation—"a potential breakthrough for millions of people worldwide who suffer from life-threatening allergies." spr.ly/6018AUcJO

A spread of foods photographed from above that are associated with common food allergens, such as peanuts, shellfish, and gluten.

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 7d

Thank you to our sponsors for their generous support: Amazon Web Services (@awscloud.bsky.social), Colton Consortium for Autoimmunity (@coltonconsortium.bsky.social), and Penn Institute for Biomedical Informatics.

Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 7d

Registration is open for the Immune Health Hackathon (Nov. 20-21)! Over the course of 48 hours, participants will work in interdisciplinary teams to tackle pressing challenges in immunology research! Open to all members of the Penn community. Register: i3hevents.org

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 8d

Earlier this month, Dr. Carl June was selected for the inaugural Broermann Medical Innovation Award for his pioneering work on CAR-T immunotherapy. He spoke with the @inquirer.com recently about the future of CAR-T research.

Penn’s CAR-T pioneer Carl June talks about the future of his award-winning work to train the body to fight cancer

The Penn scientist spoke with the Inquirer about his lab’s latest research and the future of CAR-T.

www.inquirer.com

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 18d

Registration is open! Oct 3–4 @ PA Convention Center, Philadelphia. The 2nd Annual Advancing Precision Medicine Conference: "Advances in Precision Oncology: From Genomics to Targeted Therapies" is free and in person. Ft. Nobel Laureate Dr. Kaelin. https://bit.ly/48odQpH

APM Annual Conference Philadelphia, PA - Advancing Precision Medicine

Advancing Precision Medicine Conference and Exhibition will take place at the Philadelphia Convention Center in November 1-2, 2024.

www.advancingprecisionmedicine.com

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 19d

At 3600 Civic Center Blvd, E. John Wherry, PhD welcomed Good Morning Philadelphia to Penn Medicine's new hub for hundreds of researchers in immune health, infectious disease, population health data sciences, and others engaged in cross-disciplinary collaboration. https://bit.ly/4mmwd1w

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · 21d

⏱️ Every minute in the United States, someone needs a blood transfusion because of their period. Penn’s Dr. Kathleen O’Neill is developing an mRNA therapy to treat abnormal uterine bleeding and uncover its causes—a potential breakthrough for menstrual health and #mRNA technology. bit.ly/4n8rGkB

Dr. Kathleen O’Neill points to a computer screen with imaging of a uterus.

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Sep 8

Last week, Penn Medicine leaders cut the ribbon on a new home for #immunology research. The eight-story "overbuild" at 3600 Civic Center Blvd will house I3H, #ImmuneHealth, @penncoltoncenter.bsky.social, and related areas to foster interdisciplinary collaboration.

▶️ Watch: youtu.be/Ryv2AxPtb_E?...

Building Upon Excellence: Penn’s New Collaborative Research Hub

YouTube video by Penn Medicine

youtu.be

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Sep 5

Healthy blood cells can live without ARHGAP45—but acute myeloid leukemia cells can’t. 🩸 Junwei Shi, PhD (Associate Professor of Cancer Biology) and team show a CAR T + CDC42 inhibition strategy could target AML with minimal side effects. bit.ly/45OyXQu

Blood cells and cancer cells illustration.

Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Sep 4

The Colton Center for Autoimmunity, University of Pennsylvania @penncoltoncenter.bsky.social · Sep 4

Don't miss the next installment (9/16, 11AM ET) of the #ColtonConsortium Virtual Speaker Series featuring Mark Anderson, MD, PhD (UCSF + @ucsfdc.bsky.social), a leader in #diabetes and #autoimmunity research. Registration required: bit.ly/AndersonSept16

Colton Consortium Virtual Speaker Series. Mark Anderson, MD, PhD, Robert Friend and Michelle M. Friend Endowed Chair in Diabetes Research, University of California, San Francisco. September 16, 2025, 11:00 AM ET. Registration required [QR code].

Reposted by Institute for Immunology and Immune Health (I3H)

PennMedCSO @pennmedcso.bsky.social · Aug 28

Congratulations to @joelbabdor.bsky.social (@PennSysPharmATT/ @i3h-upenn.bsky.social), recipient of a 2025 @lupusresearch.bsky.social Empowering Lupus Research Career Development Award! tinyurl.com/yc3x6n2m

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Reposted by Institute for Immunology and Immune Health (I3H)

E John Wherry @ejohnwherry.bsky.social · Aug 14

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...

www.biorxiv.org

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Aug 13

The Colton Consortium for Autoimmunity @coltonconsortium.bsky.social · Aug 13

The 2025 Colton Consortium Symposium brought together leaders, researchers, and partners from Penn, NYU, Yale, and Tel Aviv University to share their scientific breakthroughs and plan the next advances in autoimmune disease research.

🔎 Check out our recap: www.coltonconsortium.org/blog/inside-...

A smiling symposium attendee holds a microphone during an audience Q&A session.

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Aug 4

@minerlab.bsky.social

Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Aug 4

The RVCL Research Center at @upenn.edu, led by Jonathan Miner, MD, PhD, is pushing the boundaries of immune health with new discoveries about TREX1—a gene linked to RVCL, as well as cancer, autoimmune diseases, and aging. Discover how visionary philanthropy is fueling research: bit.ly/4frCSWI

RVCL Research at Penn Medicine | Inspiring Impact Magazine

Penn Medicine researchers are pioneering personalized treatments for RVCL, a rare and fatal genetic disease, with support from philanthropy.

bit.ly

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Jul 30

A new study shows Cul5 helps prevent overproduction of certain blood cells by keeping key signals in check. A common drug may help restore that balance. Read the full JCI article ft. Paula Oliver (@pennpathlabmed.bsky.social) and colleagues: www.jci.org/articles/vie...

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Jul 24

Dispatch Bio—a new startup aiming to create a universal #immunotherapy approach for all cancers—officially launched this week. Among its scientific co-founders is CAR T cell pioneer Carl June, MD—and the @upenn.edu is an early investor.

STAT @statnews.com · Jul 23

Dispatch Bio is developing a universal immunotherapy by trying to install a synthetic protein — called the “flare” antigen — on every cancer cell in a patient's body.
www.statnews.com/2025/07/23/s...

Solid tumors have challenged CAR-T developers. This biotech raised $216 million to test a new approach

Dispatch Bio is developing a universal immunotherapy by trying to install a synthetic protein — called the “flare” antigen — on every cancer cell in a patient's body.

www.statnews.com

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Jul 24

Mitochondrial complex IV remodeling plays a key role in how macrophages adapt to their surroundings—findings with major implications for #immunotherapy. Check out the newest study from Penn Medicine (@pennmedicine.bsky.social) researchers published in Immunity (@cp-immunity.bsky.social).

PennMedCSO @pennmedcso.bsky.social · Jul 18

ft. @megclarks, W. Mowel, @MFMich1, L. Joannas, J. Wright, I. Erickson, J. Henao-Mejia (@pennpathlabmed.bsky.social), L. Johnson, @andyjminn (@i3h-upenn.bsky.social), @rakez_krish, @delafuentelab.bsky.social (@PennPsych) & @ksimeono (@PennVet) @cp-immunity.bsky.social www.cell.com/immunity/abs...

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Reposted by Institute for Immunology and Immune Health (I3H)

PennMedCSO @pennmedcso.bsky.social · Jun 9

Join @i3h-upenn.bsky.social on 6/18 for their Year in Review Symposium ft'ing keynote speaker Ruslan Medzhitov (@yaleschoolofmed.bsky.social). Learn more➡️ tinyurl.com/298vrkbr

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Jun 5

Stay connected with us beyond Bluesky 👋 Follow the Institute for Immunology and Immune Health (I3H) on LinkedIn for deep dives into Penn’s groundbreaking #immunology research and the future of #ImmuneHealth.

www.linkedin.com/company/penn...

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Reposted by Institute for Immunology and Immune Health (I3H)

Nature @nature.com · May 31

Manufacturing CAR T cells in the laboratory is expensive and time-consuming.

An in vivo approach could get this powerful therapy to more people
https://go.nature.com/45w5A5w

Cancer-fighting immune cells could soon be engineered inside our bodies

Nature - Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.

go.nature.com

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Reposted by Institute for Immunology and Immune Health (I3H)

David A. Hill, MD, PhD @drdavidhill.bsky.social · May 29

I'm very excited to share that @upenn.edu @i3h-upenn.bsky.social #MSTP and Hill Lab student Julia Chini will be defending her #PhD thesis on #CD9, #obesity, and #macrophages on Wednesday, June 11th at 1PM in BRB Auditorium. Please join us as we support and celebrate Julia!

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · Jun 4

Carl June and Bruce Levine of @upenn.edu—along with Isabelle Rivière, and Michel Sadelain (formerly of @mskcancercenter.bsky.social)— have been jointly awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing chimeric antigen receptor (CAR) T-cell therapy. bit.ly/43G8kec

2025 Merkin Prize in Biomedical Technology awarded to pioneers of CAR T-cell therapy

bit.ly

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Reposted by Institute for Immunology and Immune Health (I3H)

PennMedCSO @pennmedcso.bsky.social · May 23

A next-generation “armored” CAR T cell therapy showed promising results in a small study of patients with B-cell lymphoma who had exhausted other treatment options ft. @carlhjune (@pennpathlabmed.bsky.social) & Jakub Svoboda (@penncancer.bsky.social) @i3h-upenn.bsky.social tinyurl.com/3ejw9334

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Institute for Immunology and Immune Health (I3H) @i3h-upenn.bsky.social · May 21

Deputy Director of Innovation and Technology (I3H) and Associate Professor of Genetics (Perelman School of Medicine), Dr. Golnaz Vahedi (@vahedilab.bsky.social), discussed "Chromatin topology at paralogous transcription factors" during a recent "Global Immunotalks" seminar. Check it out!

Global Immunotalks @globalimmuno.bsky.social · May 7

The recorded video of Dr. Golnaz Vahedi seminar entitled Chromatin topology at paralogous transcription factors is now available at “Global Immunotalks” YouTube Channel youtube.com/live/7aw_Qx5...
Please ask questions in the Youtube comment section for Golnaz.
Hope you enjoy it!

GLOBAL IMMUNOTALKS: Virtual immunology seminar series

YouTube video by GLOBAL IMMUNOTALKS

youtube.com

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