Dexmed as primary sedatives:
- SPICE-III🇦🇺 No mortality benefit, ?merit in older MV patient
- 🆕A2B 🇬🇧no difference in early extubation

Dexmed as an adjunct:
- DahLIA🇦🇺early extubation in agitated MV pt
- DESIRE🇯🇵 no mortality benefit in septic pt on MV

🆕on @jama.com
jamanetwork.com/journals/jam...

🇮🇹What a surprise - it seems like CXR is rarely used nor recommended for cvc position confirmation. Ecg or echo instead

journals.sagepub.com/doi/10.1177/...

Introducing Underwater SEAL 🦭🦭🦭

In critically ill adults with acute brain injuries, SDD reduced in-hospital mortality and improved ICU outcomes, including fewer infections and shorter ventilation duration, with no similar benefit seen in patients without brain injuries. zurl.co/pQAjr

In selected ICU patients with hospital-acquired bloodstream infections, 7–10 day antibiotic therapy reduced treatment failure at 28 days compared to longer courses, mainly by lowering subsequent infections, without increasing mortality. zurl.co/kEdQa

6% reduction in 1y mortality seems too good to be true - ?chance ?missing outcome

Secondary decompressive craniectomy was linked to better outcomes in TBI patients, while barbiturates were associated with worse results. Guideline adherence was limited but showed a trend toward improved outcomes. zurl.co/PDjBw

🧓🏽🛌 Frailty matters—even after surgery.

In this multicentre ICU cohort 🇦🇺(n=216k), frailty (CFS 5–8) was associated with significantly shorter 4-year survival 🕰️💔

🚨 New in BJA:
🔗 authors.elsevier.com/c/1k~Co1dCDy...

@bjajournals.bsky.social