Macrophysiological System
@invitroveritas.bsky.social
I'm like the full-sized version of an organ-on-a-chip. Brain organoids, veganism, feminism, pragmatic progressivism, sometimes grad school & parenting. Critics rave: "The least annoying bad takes I've seen all week"
imho the point of trying to recapitulate aspects of ASD in organoids isn't to "cure" ASD, or even to understand ASD.
The point is that autistic brains work differently in diverse ways, such that imitating the perturbations associated with ASDs can help identify key events in human neurodevelopment.
The point is that autistic brains work differently in diverse ways, such that imitating the perturbations associated with ASDs can help identify key events in human neurodevelopment.
December 13, 2024 at 5:59 PM
imho the point of trying to recapitulate aspects of ASD in organoids isn't to "cure" ASD, or even to understand ASD.
The point is that autistic brains work differently in diverse ways, such that imitating the perturbations associated with ASDs can help identify key events in human neurodevelopment.
The point is that autistic brains work differently in diverse ways, such that imitating the perturbations associated with ASDs can help identify key events in human neurodevelopment.
Very neat concept—and a great illustration of the experimental & moral case for brain organoids.
There's just no reason why in 2024, characterizing the effects of defined mechanical forces on living neural tissue should require guesstimating how hard to hit a rat on the head with a steel implement
There's just no reason why in 2024, characterizing the effects of defined mechanical forces on living neural tissue should require guesstimating how hard to hit a rat on the head with a steel implement
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
December 9, 2024 at 2:39 AM
Very neat concept—and a great illustration of the experimental & moral case for brain organoids.
There's just no reason why in 2024, characterizing the effects of defined mechanical forces on living neural tissue should require guesstimating how hard to hit a rat on the head with a steel implement
There's just no reason why in 2024, characterizing the effects of defined mechanical forces on living neural tissue should require guesstimating how hard to hit a rat on the head with a steel implement
Many vegan cheeses are tasty, but almost none are actually "cheeses": (plant) milk solids that have been curdled, pressed, & ripened.
Closest common approximation of actual vegan cheese is soy cheese, ie tofu—outside Asia, mostly only available as a plain "fresh cheese" 1/3
Closest common approximation of actual vegan cheese is soy cheese, ie tofu—outside Asia, mostly only available as a plain "fresh cheese" 1/3
December 8, 2024 at 2:47 AM
Many vegan cheeses are tasty, but almost none are actually "cheeses": (plant) milk solids that have been curdled, pressed, & ripened.
Closest common approximation of actual vegan cheese is soy cheese, ie tofu—outside Asia, mostly only available as a plain "fresh cheese" 1/3
Closest common approximation of actual vegan cheese is soy cheese, ie tofu—outside Asia, mostly only available as a plain "fresh cheese" 1/3
My birchbark brains were a hit at the lab gift exchange!
#BrainArt #neuroart #neurodev #Neuroskyence
#BrainArt #neuroart #neurodev #Neuroskyence
December 7, 2024 at 4:17 AM
My birchbark brains were a hit at the lab gift exchange!
#BrainArt #neuroart #neurodev #Neuroskyence
#BrainArt #neuroart #neurodev #Neuroskyence
Digital mockup for lab gift exchange art is done! Different colors represent germinal zones/cortical plate, basal nuclei anlage, choroid plexus, and other brain parenchyma.
#devneuro followers—can you catch any mistakes before I start cutting out the pieces?
#devneuro followers—can you catch any mistakes before I start cutting out the pieces?
November 29, 2024 at 6:28 PM
Digital mockup for lab gift exchange art is done! Different colors represent germinal zones/cortical plate, basal nuclei anlage, choroid plexus, and other brain parenchyma.
#devneuro followers—can you catch any mistakes before I start cutting out the pieces?
#devneuro followers—can you catch any mistakes before I start cutting out the pieces?
Kudos to the Camp/Theis/Treutlein labs for compiling this amazing resource for the field!
Particularly interesting addition since the preprint: comparison to fetal data beyond the first trimester, finding that organoids start modeling the second right on schedule but also retain early signatures
Particularly interesting addition since the preprint: comparison to fetal data beyond the first trimester, finding that organoids start modeling the second right on schedule but also retain early signatures
November 22, 2024 at 5:14 AM
Kudos to the Camp/Theis/Treutlein labs for compiling this amazing resource for the field!
Particularly interesting addition since the preprint: comparison to fetal data beyond the first trimester, finding that organoids start modeling the second right on schedule but also retain early signatures
Particularly interesting addition since the preprint: comparison to fetal data beyond the first trimester, finding that organoids start modeling the second right on schedule but also retain early signatures
Reposted by Macrophysiological System
The NIH has issued 2⃣ #funding opportunities to develop #microphysiologicalsystems (organs-on-chips/tissue chips) for human #neuroscience research. 🧠 The use of non-human tissues will not be considered. Take note of the deadlines below! grants.nih.gov/grants/guide...
#NAMs #OOCs
#NAMs #OOCs
November 18, 2024 at 1:49 PM
The NIH has issued 2⃣ #funding opportunities to develop #microphysiologicalsystems (organs-on-chips/tissue chips) for human #neuroscience research. 🧠 The use of non-human tissues will not be considered. Take note of the deadlines below! grants.nih.gov/grants/guide...
#NAMs #OOCs
#NAMs #OOCs
life before ImageJ!
November 15, 2024 at 4:57 PM
life before ImageJ!
Some life scientists are defensive about calls to replace animal research, but polls show it's what the citizens who fund us want.
With antivaxxers in power & trust in sci falling, we should jump at the chance to show we share popular values by incorporating & talking up more non-animal methods
With antivaxxers in power & trust in sci falling, we should jump at the chance to show we share popular values by incorporating & talking up more non-animal methods
November 15, 2024 at 2:06 PM
Some life scientists are defensive about calls to replace animal research, but polls show it's what the citizens who fund us want.
With antivaxxers in power & trust in sci falling, we should jump at the chance to show we share popular values by incorporating & talking up more non-animal methods
With antivaxxers in power & trust in sci falling, we should jump at the chance to show we share popular values by incorporating & talking up more non-animal methods
2015 was a simpler time
November 14, 2024 at 5:52 PM
2015 was a simpler time
Making my first single-cell RNA sequencing library and it's an oddly spiritual experience. Years of hopes and dreams concentrated into one drop of clear liquid, purified over and over, invisibly shimmering with millions of precious data points like a pearl in Indra's net
November 14, 2024 at 2:19 PM
Making my first single-cell RNA sequencing library and it's an oddly spiritual experience. Years of hopes and dreams concentrated into one drop of clear liquid, purified over and over, invisibly shimmering with millions of precious data points like a pearl in Indra's net
Hi Bluesky! I work on stem-cell-based alternatives to animal models of human brain development, have many opinions both correct and spicy, and sometimes take pretty pictures
November 14, 2024 at 3:47 AM
Hi Bluesky! I work on stem-cell-based alternatives to animal models of human brain development, have many opinions both correct and spicy, and sometimes take pretty pictures