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jacksonlab.bsky.social
The Jackson Laboratory
@jacksonlab.bsky.social
3.1K followers 48 following 310 posts
Est. 1929, JAX is a non-profit scientific research institute specializing in genetics, genomics & mouse models of disease.

USA, Japan, China: https://www.jax.org/
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jacksonlab.bsky.social
✨ Did you know JAX offers free, self‑paced online MicroLessons (15 minutes) and Mini‑Courses (1–2 hours)?

👉 MicroLessons: https://education.learning.jax.org/page/online-microlessons
👉 Mini‑Courses: https://education.learning.jax.org/page/online-minicourses
January 2, 2026 at 11:17 AM
jacksonlab.bsky.social
We know it's New Years Eve, but these aren't fireworks 🎇!

Check out this microscopy image of neural progenitor cells — multipotent, self-renewing cells in the central nervous system that generate neurons and glial cells in the 🧠.

Credit: Pera Lab at JAX
January 1, 2026 at 12:15 AM
jacksonlab.bsky.social
New year, new era of discovery. Thank you for all of your support this year and we can’t wait to share 2026 with you. Happy New Year from all of us at The Jackson Laboratory!
December 30, 2025 at 8:56 AM
jacksonlab.bsky.social
We're sharing some of our most popular posts of 2025. JAX developed mouse models that survive premature death and enable pre-clinical testing of #AHC. https://www.jax.org/news-and-insights/2025/july/mouse-models-for-ultra-rare-disorder-could-pave-the-way-for-nervous-system-gene-editing-therapies
Two scientists in lab coats. The Jackson Laboratory Logo and text reads "Mouse models for ultra-rare disorder could pave the way for nervous system gene editing therapies" TEXT READS Scientists at JAX have developed mouse models that survive premature death and enable pre-clinical testing of alternating hemiplegia of childhood (AHC) a devastating and sometimes fatal neurological disorder that affects about one in a million children with no treatment yet. The models offer clear insights into how alternating hemiplegia of childhood progresses—and how it might be stopped. A stylized quote with a headshote. White text on black background. Text reads: "We need to stop thinking about AHC as a rare disease and start thinking about it and other rare diseases as genetic disorders at large. We’re not just studying specific disorders and their underlying disease mechanisms in isolation — we’re advancing therapeutic technologies that could eventually treat many genetic disorders associated with common neurological conditions." - Cat Lutz, Ph.D., MBA, Vice president JAX Rare Disease Translational Center Text reads: The research comes from JAX’s Rare Disease Translational Center, which focuses on bridging the gap between genetic research and clinical treatment by working closely with other scientific organizations, families, and patient foundations to drive therapies for rare diseases.
December 28, 2025 at 8:42 PM
jacksonlab.bsky.social
As we head into 2026, we're sharing some of our most popular posts of 2025. This featured image taken at JAX of was our most popular image of the year on social media. It shows a single-cell spatial transcriptomic map of the human endometrium (the inner lining of the uterus). 🔬
This colorful image maps the human endometrium at the single-cell level, with each color representing a different cell type or gene within the uterus’s lining. Yellow and dark pink represent the epithelial glandular cells— specialized epithelial cells that form glands to secrete various substances to prepare for and facilitate the embryo implantation and maintain pregnancy. Purple shows the basal epithelial cells, which contain progenitor cells located at the base of the endometrium. They are anchored to the basement membrane and serve as a source of new cells for the epithelium. The light pink, green and light and dark blues on the image show fibroblasts, which are cells that form and maintain connective tissue. The dots on the image show different genes: orange (MUC1), pink (EPCAM), red (MME), and yellow (THY1).
December 26, 2025 at 8:39 PM
jacksonlab.bsky.social
This new featured image from JAX shows a 3D rendering revealing the intricate interior of a human stem cell, centered around a prominent blue nucleus. 🔬 🧪

Learn more: https://www.jax.org/news-and-insights/2025/december/understanding-the-structure-of-a-stem-cell
a 3d polygonal model of a stem cell
December 23, 2025 at 7:31 PM
jacksonlab.bsky.social
#CARDIOVERSE: Combining AI, stem cells & genetic variation to predict drug safety before human trials. By building virtual hearts, JAX scientists aim to dramatically reduce the need for large-animal studies, streamline approvals & ensure safer, faster delivery to patients. go.jax.org/cardioverse
Infographic depicting CARDIOVERSE, a platform by The Jackson Laboratory that predicts cardiac risks by integrating data from genetically diverse mice and human stem cells. The image includes illustrations of different colored mice, a heart tissue sample, and human induced pluripotent stem cells (iPSCs). Alt Text: "A computer monitor displays a digital image featuring a large, central heart shape composed of intricate lines, surrounded by smaller multicolored heart shapes. The text beneath discusses the capabilities of CARDIOVERSE in estimating heart safety risks based on human genetic backgrounds." Two charts depicting drug response signals. The first chart shows multiple line graphs of varying colors representing individual risk scores. The second chart displays an array of medicines, organized in rows, illustrating different studies on cardiac response to medications. The text discusses the use of these models to predict the impact of drugs on human hearts. Graphic of six silhouetted figures with a gradient fill, standing next to an oversized capsule pill, representing a focus on clinical trials in drug development. Text describes the virtual screening of drug candidates to prioritize safer, cheaper therapies.
December 22, 2025 at 9:26 PM
jacksonlab.bsky.social
Developing new drugs is one of the riskiest and most expensive endeavors in science, but a new project led by The Jackson Laboratory aims to change that. JAX's new CARDIOVERSE project combines AI, stem cells, and genetic variation to predict drug safety before human trials. 🧪 go.jax.org/cardioverse
December 17, 2025 at 3:46 PM
jacksonlab.bsky.social
The EndoRISE Fall Forum, hosted by JAX, spotlighted groundbreaking science, patient-centered solutions, and the power of partnership to transform outcomes for millions living with endometriosis.

📰 Read the story: https://go.jax.org/ERForum2025

📼 View clips from the event in the comments ⤵️
December 12, 2025 at 9:01 PM
jacksonlab.bsky.social
Thanks to an up to $30M contract award from ARPA-H, JAX aims to revolutionize drug safety testing with the #CARDIOVERSE—a new project that combines #AI, #stemcells, and #genetic variation to predict #drugsafety before human trials. 💊 🧪 🔬 🤖

go.jax.org/cardioverse
a microscopy image of stem cells in the shape of a heart. White text on black reads: Welcome to the CARDIOVERSE. JAX receives an up to $30M contract award to revolutionize drug safety testing with AI-powered "virtual hearts"
December 8, 2025 at 9:44 PM
jacksonlab.bsky.social
We are grateful for the incredible people who make our mission possible. From the patients and families who inspire us, to the researchers, partners and supporters who fuel discovery, thank you for being part of the JAX community.

Together, we're advancing science and improving human health.
November 26, 2025 at 4:58 PM
jacksonlab.bsky.social
As winter approaches, we’re reflecting on the incredible work happening at JAX. Thank you, Commissioner Michael Duguay of the Maine Department of Economic and Community Development, for visiting this week to learn about our work and the impact of state support on our mission to improve human health.
November 21, 2025 at 9:10 PM
jacksonlab.bsky.social
What does it take to turn a bold idea into a life-changing treatment? At JAX, innovation is more than progress — it’s the power to transform lives.
November 19, 2025 at 11:39 PM
jacksonlab.bsky.social
Biomarker testing + the expertise to interpret results are essential to precision cancer care. MCGI & @jaxeducation.bsky.social are closing the gap to precision oncology.

Get the details: https://go.jax.org/connectingthedots

#CancerBiomarkerDay #GeneticCounselorAppreciationDay 💙
November 13, 2025 at 8:46 PM
jacksonlab.bsky.social
The bold new alliance between JAX and NSYCF promises to transform biomedical research and bring life-changing therapies to patients faster than ever before. 🧬 🧪 🔬

Learn more: www.jax.org/news-and-insights/2025/october/scope-speed-scale-

cobolt blue background with the text SCOPE. SPEED. SCALE. A powerful alliance to accelerate the pace of discovery.
October 22, 2025 at 11:31 PM
jacksonlab.bsky.social
“From the laboratory bench to the executive suite” — powerful insights on leadership, resilience, and purpose from Joanne Berger-Sweeney at the Hewett Family Lecture. Congratulations to our Hewett Leadership graduates, and thank you for continuing to inspire the future of nonprofit leadership.
October 21, 2025 at 7:06 PM
jacksonlab.bsky.social
Join the JAX Technical Information Scientists team to learn how to leverage ALS biomarkers to track disease progression in mouse models: https://jackson.jax.org/jax-event-10212025.html?utm_source=linkedin&utm_medium=organic_social&utm_campaign=2025_10_21_webinar&utm_content=post
October 14, 2025 at 6:52 PM
jacksonlab.bsky.social
Researchers at the Toulouse Institute for Infectious and Inflammatory Diseases characterized human mast cell development in the JAX CD34+ HSC humanized NSG-SGM3-IL15 model. Read the full publication: https://doi.org/10.1111/all.70058 & learn more by exploring the JAX HuMice Platform
October 1, 2025 at 10:13 PM
jacksonlab.bsky.social
🧪🤝🖥️ 🧬   Our buildings glow green for World Cancer Research Day—honoring the work of our scientists, including the JAX Cancer Center’s NCI rating of exceptional, and MCGI’s breakthroughs, setting a new standard for community-based oncology.

We’re proud to light the way forward in cancer research.
September 24, 2025 at 4:00 PM
jacksonlab.bsky.social
Same mission. Different methods. Radiation, chemo, immunotherapy—each fights cancer in its own way.

Want to understand how? 🎬 5 minutes of the basics: https://youtu.be/cT3E1OzxZnY

Discover more resources just like this: www.jax.org/patients
September 10, 2025 at 5:17 PM
jacksonlab.bsky.social
“Our study achieved 90% accuracy in distinguishing individuals with chronic fatigue syndrome, which is significant because doctors currently lack reliable biomarkers for diagnosis,” said study author Derya Unutmaz.
“Our study achieved 90% accuracy in distinguishing individuals with chronic fatigue syndrome, which is significant because doctors currently lack reliable biomarkers for diagnosis. “Some physicians doubt it as a real disease due to the absence of clear laboratory markers, sometimes attributing it to psychological factors," said Derya Unutmaz, JAX Profession in Immunology
July 25, 2025 at 3:38 PM
jacksonlab.bsky.social
The research reveals how hidden DNA variations influence everything from digestion and immune response to muscle control—and could explain why certain diseases strike some populations harder than others....
July 23, 2025 at 9:04 PM
jacksonlab.bsky.social
What does a rare ovarian tumor look like—cell by cell? This stunning image reveals a Sertoli-Leydig tumor at the single-cell level, highlighting the diverse cell types that make up its complex microenvironment. 🔬🧬🧪

Learn more: www.jax.org/news-and-ins...
This is a rare type of tumor called Sertoli-Leydig tumor, which makes up fewer than 0.5% of all ovarian tumors. Though rare, Sertoli-Leydig tumors can cause significant hormonal imbalances. All tumors are heterogeneous. That means they’re made up of lots of different types of cells all working together. This colorful image shows the tumor tissue at the single-cell level. Each color highlights a different cell type within the tumor’s complex microenvironment. Cutting-edge imaging tools like single-cell sequencing can help scientists visualize and understand how cells work together (or against each other) in a tumor environment. The blue ovals are the nuclei of individual cells. Yellow highlights the endothelial cells that form blood vessels, while magenta and cyan mark different types of epithelial tumor cells. The green strands represent myofibroblasts and perivascular cells—supporting cells often involved in tissue remodeling. Orange spots show macrophages, a type of immune cell that helps clear debris, and red marks antigen-presenting cells, which help alert the immune system to potential threats.
July 17, 2025 at 7:43 PM
jacksonlab.bsky.social
📘 New in Redox Biology, "Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics" with Susan McClatchy & Gary Churchill:

doi.org/10.1016/j.re...

#jaxresearch 🧪🤝🖥️ 🧬 ⑂ #ScientificResearchPublishing
scientific image showing phenotype processing
July 16, 2024 at 1:50 PM
jacksonlab.bsky.social
📔 New review in Neuropharmacology, "Strategies to dissect microglia-synaptic interactions during aging and in #Alzheimer's disease" by Sarah Heuer, Erik Bloss & Gareth Howell:

🧪🤝🖥️ 🧬 ⑂ #jaxresearch #ScientificResearchPublishing
#alzsky #Neuroscience

doi.org/10.1016/j.ne...
scientific illustration
May 30, 2024 at 12:53 PM