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Jacob Smith

@jacobsmithsci.bsky.social

890 followers 1K following 27 posts

PI @UniBarcelona @IBUB_UB. https://sites.google.com/view/smithlab-ibub/home?authuser=0 Circadian clocks and inter-organ crosstalk.

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Jacob Smith @jacobsmithsci.bsky.social · Jan 3

🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE

Circadian clock communication during homeostasis and ageing

Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...

rdcu.be

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Reposted by Jacob Smith

Sdelci Lab @sdelcilab.bsky.social · Jul 30

🚀 We’re excited to share our latest publication in collaboration with Verena Ruprecht's group at @crg.eu

Mechanobiology meets Nuclear Metabolism

www.nature.com/articles/s41...

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications

The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...

www.nature.com

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Jacob Smith @jacobsmithsci.bsky.social · Aug 1

🥳🎉 Congrats @ritoghose.bsky.social and @sdelcilab.bsky.social Beautiful data!!

Jacob Smith @jacobsmithsci.bsky.social · Jul 22

🧪 Really cool new #circadian paper looking at the role of the liver clock in inter-organ crosstalk with muscle during Cachexia "Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia": Cell www.cell.com/cell/fulltex...

Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia

Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

www.cell.com

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Jacob Smith @jacobsmithsci.bsky.social · Jun 23

Part time (20h per week) technician/predoc position available in my lab at the University of Barcelona 🧬⏰ studying circadian rhythms & inter-organ crosstalk.

Starts 1st Sept 2025.

Contact via email link in website (sites.google.com/view/smithla...) for more info

#ScienceJobs #Barcelona #Circadian

Jacob Smith @jacobsmithsci.bsky.social · Jun 16

Yeh a lot do for sure- its really sad- about 50% voted for him at least (49.9% of popular vote was for Trump in 2024). Reminds me of the percentages for Brexit in UK (another terrible and embarrasing decision), 52% for, 48% against. Signs of deeply divided populations...

Jacob Smith @jacobsmithsci.bsky.social · Jun 14

🧪 Encouraging to see people standing up against tyranny and fascism in the US. The Trump administration’s anti-science and pro-war agenda isn’t just dangerous at home — it threatens progress and stability worldwide. Enough!

Mark Hamill @markhamillofficial.bsky.social · Jun 14

TODAY 6/14/25, we peacefully make our voices heard... NO KINGS!* 🇺🇸

*Also NO: CONVICTED FELONS/PATHOLOGICAL LIARS/DRAFT DODGERS/ADJUDICATED RAPISTS/SHORT-FINGERED VULGARIANS/MALIGNANT NARCISSISTS & ANYONE WHO INCITED AN INSURRECTION IN AN ATTEMPTED COUP AGAINST HIS OWN COUNTRY a/k/a TRAITORS ✊

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Reposted by Jacob Smith

Carl T. Bergstrom @carlbergstrom.com · Jun 5

The failure of the National Academy of Sciences USA to make a clear and unequivocal statement about the disastrous Trump administration science policies — it lets all of us down and dooms them to eventual irrelevance.

US science is being wrecked, and its leadership is fighting the last war

Facing an extreme budget, the National Academies hosted an event that ignored it.

arstechnica.com

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Reposted by Jacob Smith

Philip Ball @philipcball.bsky.social · Mar 8

US science folks: it's been really heartening to see all the Stand Up For Science posts. Thank you for showing the backbone and resolve that most institutions have lacked.

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Jacob Smith @jacobsmithsci.bsky.social · Mar 7

Great to see US scientists protesting in response to the insanity that is the US "government" right now. @standupforscience.bsky.social 🧪

Lauren Magliozzi, PhD 💧 @limnologylauren.bsky.social · Mar 7

Just finished our signs for @standupforscience.bsky.social 🧪

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Reposted by Jacob Smith

Alexis A. Jourdain @jourdainlab.bsky.social · Jan 30

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

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Jacob Smith @jacobsmithsci.bsky.social · Jan 30

Congrats and many thanks for sharing, this is really informative!

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Jacob Smith @jacobsmithsci.bsky.social · Jan 8

Thanks Pablo! 🙏

Jacob Smith @jacobsmithsci.bsky.social · Jan 7

Hi, you can check my post for the free SharedIt link. If it doesn't work let me know

Jacob Smith @jacobsmithsci.bsky.social · Jan 7

Check my profile for the sharedit link, thanks

Reposted by Jacob Smith

Eric Topol @erictopol.bsky.social · Jan 5

As we age, our circadian clock goes off-track, which may contribute to age-related diseases. A new review paper gets into the mechanisms and potential ways to prevent the decline www.nature.com/articles/s41...

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Jacob Smith @jacobsmithsci.bsky.social · Jan 3

Circadian clock communication during homeostasis and ageing

Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...

rdcu.be

3 9 25

Jacob Smith @jacobsmithsci.bsky.social · Dec 6

Congrats to you, your team and collaborators on a series of amazing manuscripts! 👏🤯

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Jacob Smith @jacobsmithsci.bsky.social · Dec 6

Wow, this is quite wild!

Oded Rechavi @odedrechavi.bsky.social · Dec 5

...and it doesn't end there: In a 2nd @biorxivpreprint.bsky.social that we posted back-to-back with @bjornschumacher.bsky.social‘s lab we show that in addition to affecting epigenetic inheritance, temperature perception controls genetic inheritance via transposons!
www.biorxiv.org/content/10.1...

Thermosensory neurons control genetic inheritance through regulation of germline transposons

Epigenetic inheritance can be influenced by environmental conditions and somatic inputs originating from different tissues. Such transgenerational inheritance is reversable as it does not lead to muta...

www.biorxiv.org

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Jacob Smith @jacobsmithsci.bsky.social · Dec 4

Hi Pancho, can I be added please? 🙏

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Reposted by Jacob Smith

Itai Yanai @itaiyanai.bsky.social · Nov 30

It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.

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Jacob Smith @jacobsmithsci.bsky.social · Nov 29

Hi Christian, could you please add me to this? 🙏 all the best

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Jacob Smith @jacobsmithsci.bsky.social · Nov 26

Wow, this is cool. Non natural cis elements designed in silico that are more effective than natural

Jalees Rehman @jalees.bsky.social · Nov 26

Machine-guided design of cell-type-targeting cis-regulatory elements

www.nature.com/articles/s41... @natureportfolio.bsky.social

Machine-guided design of cell-type-targeting cis-regulatory elements - Nature

A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

www.nature.com

Reposted by Jacob Smith

Nicholas Per Huffeldt @nphuffeldt.bsky.social · Nov 25

If you just moved to BlueSky and interested in #chronobiology, find some of your community here!

Want to be added? Reply with evidence your work relates to chronobiology.

go.bsky.app/Sw8L4aS

With all the new people coming over, I’ll repost weekly for the next month or so.

🧪 🌍 🦑 #EvoBio

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Jacob Smith @jacobsmithsci.bsky.social · Nov 25

Hi Nicholas 👋, could you add me please 🙏🕙💪 www.cell.com/cell-reports...

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Smith et al. rescued circadian clock function in liver and muscle in otherwise clock-less mice, finding that glucose tolerance is achieved only when feeding rhythms and Bmal1 function in liver and mus...

www.cell.com

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