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Jake Toth

@jaketoth.bsky.social

150 followers 280 following 24 posts

All things neurotech 🧠 | Postdoc in transcranial ultrasound stimulation 🔊 University of Oxford | jaketoth.tech

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Jake Toth @jaketoth.bsky.social · Jul 22

My recent talk on how we can change brain activity without surgery or drugs is live!

youtu.be/EpnMdwZ7lFo?...

How Can We Change Brain Activity With Sound? | Jake Toth | Spotlight: Illuminating Engineering

YouTube video by Oxford Engineering

youtu.be

Jake Toth @jaketoth.bsky.social · 14d

“Huntington’s disease successfully treated for the first time” has got to be the best headline of 2025!

www.bbc.co.uk/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.co.uk

Reposted by Jake Toth

Boyan Ivanov @boyan-ivanov.bsky.social · 15d

My review paper on temporal interference brain stimulation just came out in Frontiers in Neurology! 🧠⚡
We cover what’s been learned from 2017–2024 and where the field is heading next.

Read it here 👉 : doi.org/10.3389/fneu...

#Neuroscience #BrainStimulation #DeepBrainModulation #Publication #TI

Frontiers | Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation

Temporal Interference (TI) stimulation has emerged as a novel, non-invasive technique for selectively modulating deep brain regions while minimizing stimulat...

doi.org

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Jake Toth @jaketoth.bsky.social · Jul 22

My recent talk on how we can change brain activity without surgery or drugs is live!

youtu.be/EpnMdwZ7lFo?...

How Can We Change Brain Activity With Sound? | Jake Toth | Spotlight: Illuminating Engineering

YouTube video by Oxford Engineering

youtu.be

Jake Toth @jaketoth.bsky.social · May 7

Last week I gave my first public talk on non-invasive brain stimulation. It was an exciting (but slightly terrifying) experience. I spoke about how we can change brain activity without surgery or drugs and the incredible potential of these technologies!

Department of Engineering Science, University of Oxford @oxengsci.bsky.social · May 6

All tickets sold out. Big questions asked. Even bigger ideas shared.🎤

After #SpotlightIE, 95% of attendees strongly agreed engineering shapes the world - up from 70% before.

Swipe to see our brilliant speakers📸

Talks coming soon on YouTube!

#OxfordEngineering #PublicEngagement

Hosts at Spotlight: Illuminating Engineering event: Dr Sara Keller, and Dr Veerle Brans

Danny Coles performing his talk at Spotlight: Illuminating Engineering

Jake Toth performing his talk at Spotlight: Illuminating Engineering

Mujan Seif performing her talk at Spotlight: Illuminating Engineering

Jake Toth @jaketoth.bsky.social · May 2

Yes - but I also think we tend to discount the value of the work we do during those years. Both PhDs and postdocs are basically just jobs producing economic value! If anything PhD's are a hyper-efficient use of resources as skilled workers produce public goods for very low pay.

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Reposted by Jake Toth

Department of Engineering Science, University of Oxford @oxengsci.bsky.social · Apr 20

What does engineering sound like when it’s reshaping your world?

Get a sneak peek from our Spotlight speakers!

🗓️ 30 April, Old Fire Station
🎟️ Book now: https://eng.ox.ac.uk/events/spotlight-illuminating-engineering-2025/
#SpotlightIE

Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.

youtu.be

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Reposted by Jake Toth

Andrew Pines @andrewpines.bsky.social · Feb 12

What brain regions are involved in causing psychotic symptoms?

Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵

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Jake Toth @jaketoth.bsky.social · Jan 28

EU reclassification of non-medical tES/TMS to Class III (high-risk) was based on shockingly weak evidence. Full details are here:

www.sciencedirect.com/science/arti...

Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III

www.sciencedirect.com

Jake Toth @jaketoth.bsky.social · Jan 20

It’s so exciting to see all the newly funded ARIA Precision Neurotechnologies projects get announced!
A full list can be found here:
www.aria.org.uk/opportunity-...

Precision Neurotechnologies

Backed by £69m, this programme aims to unlock new methods to interface with the human brain at the cellular level, with unprecedented precision.

www.aria.org.uk

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Jake Toth @jaketoth.bsky.social · Jan 20

Congratulations!

Jake Toth @jaketoth.bsky.social · Jan 14

Pleased to share that I have been selected for the 2025 Foresight Fellowship Program!
I'm excited to network with fellow Foresight members and to discuss how non-invasive brain stimulation technologies can be used and scaled in the long term. 🧠
foresight.org/fellowship/2...

2025 Fellow Jake Toth

foresight.org

Reposted by Jake Toth

Sumner L. Norman @sumnerln.bsky.social · Jan 11

Hundreds of Caltech and Caltech/Nasa Jet Propulsion Lab scientists, professors, and students have lost their homes in the LA fires.

The Disaster Relief Fund is organized to help. Please share.
giving.caltech.edu/areas-to-sup...

The Caltech and JPL Disaster Relief Fund

giving.caltech.edu

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Jake Toth @jaketoth.bsky.social · Jan 11

Interested in inclusive neurotechnology design?
I highly recommend applying for this postdoc position.
www.jobs.ac.uk/job/DLJ593/r...

Research Associate in Inclusive Neurotechnology Design at University of Sheffield

Apply now for the Research Associate in Inclusive Neurotechnology Design role on jobs.ac.uk - the leading job board for higher education jobs. View details.

www.jobs.ac.uk

Reposted by Jake Toth

TMSMultiLab @tmsmultilab.bsky.social · Jan 8

If you use brain (or nerve!) stimulation methods in human (or animal!) neuroscience, then maybe you need (to be on) this list...

#BrainStim

(please ask to be added)

go.bsky.app/395SGxh

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Jake Toth @jaketoth.bsky.social · Jan 9

No, but given the responses to this post I guess I should!

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Jake Toth @jaketoth.bsky.social · Jan 9

For those who don’t know, focused research organisations (FROs) strike a balance between the openness of research, the dynamism of start-ups, and the scale of industry. If you have a big idea in neurotechnology, consider applying to open an FRO in the UK!

Jake Toth @jaketoth.bsky.social · Jan 9

Generally, NIBS + antidepressants can have better outcomes than just NIBS or antidepressants alone. But it isn't always the case. There's a recent review on this here:
www.thelancet.com/journals/ecl...

Antidepressant class and concurrent rTMS outcomes in major depressive disorder: a systematic review and meta-analysis

The combination of rTMS with SSRIs, but not SNRIs, significantly reduced depression severity, increasing response and remission rates. Some analyses demonstrated high heterogeneity, which was influenced by an SSRI trial with a high effect size. Overall, these results suggest that not all antidepressant combination therapies are alike, and SSRIs should be considered when initiating rTMS.

www.thelancet.com

Jake Toth @jaketoth.bsky.social · Jan 9

All great questions!
Magnetic stimulation (TMS) is typically used over a 4-6 week period for less than an hour per day but a recent protocol shows good efficacy over 5 days with many sessions per day (all in the clinic). tDCS is roughly 20 mins per day for 6 weeks at home.

Jake Toth @jaketoth.bsky.social · Jan 6

What % of people with tetraplegia would turn down an implanted device to recover hand movement?

Surprisingly (to me at least) it was 29% in this survey!

www.sciencedirect.com/science/arti...

Needs of individuals with tetraplegia and expectations regarding implanted neuroprosthesis

www.sciencedirect.com

Jake Toth @jaketoth.bsky.social · Jan 2

Any predictions on AI for drug discovery, material science or science in general?

Jake Toth @jaketoth.bsky.social · Jan 2

I squeeze, stretch and push on brains

Jake Toth @jaketoth.bsky.social · Jan 1

What will the world look in 30 years?

I’m not so sure about this prediction: “By 2055, she thinks many people will be "cognitively connected" - a hive mind of humans and technology via servers, which will help in the sharing of ideas.”

www.bbc.co.uk/news/article...

Reposted by Jake Toth

John Downey @johndowney.bsky.social · Dec 30

Our new publication in Human Brain Mapping is a roadmap to implanting stimulation electrodes to evoke tactile sensations on the fingers of Brain-Computer Interface (BCI) users. We share the plan and results for 5 study participants across a decade at 2 sites.

onlinelibrary.wiley.com/doi/10.1002/...

Progression of implant plan from placement map, to surgical image, to stimulation results.

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Reposted by Jake Toth

Ido Aizenbud @idoai.bsky.social · Dec 26

Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.

Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)

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Jake Toth @jaketoth.bsky.social · Dec 18

It feels like travelling back in time!

an elderly woman in a green shirt says it 's been 84 years ...

Alt: An elderly woman in a green shirt from the movie Titanic says “Its been 84 years…”

media.tenor.com

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