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Reposted by James N. Sleigh

Ashley Kalinski @kalinskilab.bsky.social · 1d

Paper Alert!! Our collaborative work with Giger Lab at UMich is out now in #ScienceTranslationMedicine Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury | Science Translational Medicine @science.org
www.science.org/doi/10.1126/...

Deletion of murine Sarm1 results in a microenvironment that delays peripheral nerve regeneration after injury

In Sarm1-deficient mice, peripheral nervous system regeneration is delayed after injury.

www.science.org

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Reposted by James N. Sleigh

Coleman Lab @colemanlab.bsky.social · 20d

How much of what we think we ‘know’ is just trust in the person that told us?

And what price do we pay for confusing the two?

Coming soon in Science Without Anguish:

‘Don’t believe everything you think!’

sciencewithoutanguish.com

Starts Monday 22nd Sep

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James N. Sleigh @jamessleigh.bsky.social · Sep 9

Beautiful data from @dvillarroelc.bsky.social showing a key role for TBK1 in #AxonalTransport of signalling endosomes:

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @mndassoc.bsky.social #ALS #MND

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James N. Sleigh @jamessleigh.bsky.social · Sep 4

See you tomorrow - looking forward to your talk!

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Reposted by James N. Sleigh

Ali Twelvetrees @dozenoaks.bsky.social · Aug 28

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

NeuroBioUK - Programme

9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

neurobiouk.sites.sheffield.ac.uk

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James N. Sleigh @jamessleigh.bsky.social · Aug 13

Thank you, Rob!

James N. Sleigh @jamessleigh.bsky.social · Aug 12

It's an honour to become a Professor at such a wonderful institution @uclqsion.bsky.social @uclbrainscience.bsky.social. The @uclqsneuromuscular.bsky.social is an amazing place to work and I couldn't have done it without my fantastic team, mentors and collaborators:

www.ucl.ac.uk/brain-scienc...

Senior Academic and Early Career Promotions 2024-25

Huge congratulations to the UCL Queen Square Institute of Neurology staff who have been awarded a promotion in this year's promotions round.

www.ucl.ac.uk

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Reposted by James N. Sleigh

Tom Gillingwater @tomgillingwater.bsky.social · Aug 1

🚨 New #ALS #MND publication from our lab (co-lead @drchayts.bsky.social), in collaboration with Bernát Nógrádi and colleagues from Hungary and Sonia Alonso-Martin and colleagues from Spain, just published in @natcomms.nature.com -> rdcu.be/eyNIs

The CCL2-CCR2 axis drives neuromuscular denervation in amyotrophic lateral sclerosis

Nature Communications - Neuromuscular junctions (NMJs) are denervated in amyotrophic lateral sclerosis (ALS) through unknown mechanisms. Here, the authors show immune cells infiltrating muscle of...

rdcu.be

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Reposted by James N. Sleigh

Department of Neuromuscular Diseases, UCL QSION @uclqsneuromuscular.bsky.social · Jul 9

Next UCL ALS-FTD Network Seminars - 25 July at 4pm, Gilliatt LT, QSH.

'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs'

'Generation of a universal human cellular platform for drug testing in ALS'

'A forebrain organoid model of progranulin-associated FTD'

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Reposted by James N. Sleigh

Andreas Prokop @poppi62.bsky.social · Jul 3

Microtubule curling as an efficient readout to uncover fundamental concepts of axonal

doi.org/10.1101/2025...

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Reposted by James N. Sleigh

Department of Neuromuscular Diseases, UCL QSION @uclqsneuromuscular.bsky.social · Jul 1

Delighted that the department has been awarded Gold for Laboratory Efficiency Assessment Framework (LEAF) 2025. We were commended on the labs signage, management and sustainable initiatives across the whole department.

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James N. Sleigh @jamessleigh.bsky.social · Jun 27

I’m super happy for you Gita - thoroughly well deserved!

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Reposted by James N. Sleigh

ithinkwellhugh.bsky.social @ithinkwellhugh.bsky.social · Jun 20

#ResearchResources:
Lots of great free resources for researchers & research students. Thesis planners, goal setting tools, agendas, To-Do lists. Completely customisible and free. No login, no catches. Just download & use. From: buff.ly/2L0YISj #PhDchat #ECRchat #postdoc

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Reposted by James N. Sleigh

Journal of Anatomy @journalofanatomy.bsky.social · Jun 18

We welcome Volume 247 with this fantastic image from work by Sosa et al. This study provides the first comprehensive description of the hindlimb musculature of the #Emperor #Penguin (Aptenodytes forsteri) across different ontogenetic stages. doi.org/10.1111/joa....

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Reposted by James N. Sleigh

Nicol Birsa @nicolbirsa.bsky.social · Jun 18

Very excited to share our latest preprint! We looked at loss and gain of function, innervation, reinnervation, and in vivo axonal transport in a FUS-ALS mouse model!

www.biorxiv.org/content/10.1...

@uclqsion.bsky.social @beccasimkin.bsky.social @andrewtosolini.bsky.social @frattalab.bsky.social

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Reposted by James N. Sleigh

Shane Liddelow @liddelowsa.bsky.social · Jun 15

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity

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Reposted by James N. Sleigh

Tom Gillingwater @tomgillingwater.bsky.social · Jun 16

New paper from the lab 🚨: Expansion microscopy reveals nano-scale insights into the human neuromuscular junction: Cell Reports Methods www.cell.com/cell-reports...

Expansion microscopy reveals nano-scale insights into the human neuromuscular junction

Ramadan et al. employ expansion microscopy to visualize neuromuscular junctions in human and mouse muscles. Their findings demonstrate expansion microscopy as an accessible and cost-effective approach...

www.cell.com

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Reposted by James N. Sleigh

Ali Twelvetrees @dozenoaks.bsky.social · Jun 6

Registration is now open for NeuroBioUK 2025!
This year we're looking forward to hearing from our plenary speaker @cathyabbott.bsky.social. As ever, all other talks chosen from submitted abstracts so get submitting - we can't wait to see you there!

neurobiouk.sites.sheffield.ac.uk/registration

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

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James N. Sleigh @jamessleigh.bsky.social · Jun 4

Very pleased for you, Melissa! Well done and congratulations, Prof!

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James N. Sleigh @jamessleigh.bsky.social · May 30

Our new paper in Neurobiology of Aging showing that processivity and BDNF-dependent modulation of #AxonalTransport are impaired in aged mice:

www.sciencedirect.com/science/arti...

@dvillarroelc.bsky.social @andrewtosolini.bsky.social @alessiovagnoni.bsky.social @uclqsion.bsky.social #aging

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Reposted by James N. Sleigh

UK MND Research Institute @ukmndri.bsky.social · May 29

We are pleased to announce that the @ucl Queen Square Motor Neuron Disease Centre Sixth Hybrid #ALS/#MND International Symposium in Partnership will be held on Friday 5/9/25.

The theme is Translating Targets to Therapies.

To register, click below⬇️

www.eventbrite.co.uk/e/ucl-queen-...

UCL Queen Square MND Centre Sixth ALS/MND International Symposium

International Conference, in partnership with the UK MND Research Institute, on ALS / MND - TRANSLATING TARGETS TO THERAPIES

www.eventbrite.co.uk

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Reposted by James N. Sleigh

Ewout Groen @ewout.bsky.social · Apr 21

The last part of our SMA genetics trilogy is now online at iScience @cellpress.bsky.social! Here we use ONT technology to determine SMN2-specific methylation profiles. We find how methylation may regulate SMN with aging but it may not be a great biomarker. Have a look:

www.cell.com/iscience/ful...

Comprehensive analysis across SMN2 excludes DNA methylation as an epigenetic biomarker for spinal muscular atrophy

Spinal muscular atrophy (SMA) is a severe neurodegenerative disease caused by defects in the survival motor neuron 1 (SMN1) gene. Although disease severity partially correlates with SMN2 copy number, ...

www.cell.com

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James N. Sleigh @jamessleigh.bsky.social · May 21

If you're struggling to visualise mouse NMJs, we've got a protocol just for you!

bio-protocol.org/en/bpdetail?...

Dissection and whole-mount immunofluorescent staining of mouse hind paw muscles for #NMJ analysis

Lovely work from Rebecca Simkin @uclqsion.bsky.social @nicolbirsa.bsky.social‬

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Reposted by James N. Sleigh

Andreas Prokop @poppi62.bsky.social · May 18

The longer we have worked on and refined this #microtubule - based model of #neurodegeneration, the more convincing it becomes. It is the fruit of 20 years of work. If you are interested, join my THE CYTOSKELETON OF NEURONS AND GLIA online talk this Thurday: ncytoskeleton.wixsite.com/webinars

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Reposted by James N. Sleigh

Mike Fainzilber @mfainzilber.bsky.social · May 16

A 🧵 to walk those interested through this paper...

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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