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janikgoltermann.bsky.social
Janik Goltermann
@janikgoltermann.bsky.social
89 followers 200 following 19 posts
CBT therapist and postdoc at @traplabms.bsky.social working in neuroimaging psychiatry🧠 Topics: childhood maltreatment, neurobiology, depression and replicability / open science
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
🧠Out now @natcomms.nature.com !
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 20h
🎓 Stay tuned for upcoming PhD position opening if you are interested to learn about depression, neuroimaging and causal inference
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 20h
What causal role do brain changes play in depression?
New EKFS-funded 4-year study will tackle this question leveraging a unique longitudinal MRI datasets – up to 9 scans per patient across 16 years!

#Neuroimaging #Depression #Causality @traplabms.bsky.social @ekfstiftung.bsky.social
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Reposted by Janik Goltermann
igor-dgps.bsky.social
IGOR DGPs @igor-dgps.bsky.social · 8d
🔍 Have we solved the replication crisis?

Join us for an IGOR panel discussion on the state of Open Science in biological psychology more than a decade after the crisis first hit.

📅 Friday, 10 Oct | 10:00–11:00 CET
💻 Online (contact us for the link)

#OpenScience #neuroskyence #academicsky

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Reposted by Janik Goltermann
andreradix.bsky.social
André Radix @andreradix.bsky.social · 11d
Can brain organoids become conscious? A new paper argues it’s unlikely with today’s tech, but urges ethical debate as research advances.
www.cell.com/patterns/ful...
#neuroscience #organoids #consciousness #bioethics
Facing the possibility of consciousness in human brain organoids
The authors challenge recent claims that the emergence of consciousness in human brain organoids (HBOs) remains implausible in the near term. Drawing on neuroscientific evidence, developmental paralle...
www.cell.com
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 13d
Excited about the next chapter📖
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Reposted by Janik Goltermann
ie-nb.bsky.social
ie-nb.bsky.social @ie-nb.bsky.social · 16d
The overlapping genetic architecture of psychiatric disorders and cortical brain structure

https://www.newsbeep.com/ie/35167/

Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007). Article  PubMed …
The overlapping genetic architecture of psychiatric disorders and cortical brain structure - Ireland News Beep
Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nat. Rev. Neurosci. 8, 725–732 (2007).
www.newsbeep.com
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Reposted by Janik Goltermann
thomas-zhihao-luo.bsky.social
Thomas Luo @thomas-zhihao-luo.bsky.social · 20d
How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com
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Reposted by Janik Goltermann
brandy-syglass.bsky.social
Brandy A Freitas @brandy-syglass.bsky.social · Apr 17
🧠 The #MICrONS project just released the most detailed brain map ever—82K neurons, 523M synapses, all open for exploration. Dive in thanks to #BossDB: github.com/aplbrain/bos...

#Neuroscience #OpenScience #Connectomics #3DThursday #syGlass @alleninstitute.bsky.social @jhuapl.bsky.social
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Reposted by Janik Goltermann
infodocket.newsie.social.ap.brid.gy
infoDOCKET @infodocket.newsie.social.ap.brid.gy · 21d
NEW Journal Article: "The Economic Impact of Open #Science: A Scoping Review" https://www.infodocket.com/2025/09/17/journal-article-the-economic-impact-of-open-science-a-scoping-review/ #OpenScience #os #oa #oss #ofd
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 20d
I'd be happy to but unfortunately, the availability of pediatric samples is limited at our lab. We are currently conducting a series of direct replications but mostly with adult samples so far. However, I would love to expand this to other labs and datasets if you are interested
Reposted by Janik Goltermann
igor-dgps.bsky.social
IGOR DGPs @igor-dgps.bsky.social · 21d
📣 Attending #ICON2025?
Don’t miss this symposium today at 13:45!

Featuring @alinakoppold.bsky.social who will present an ongoing IGOR project: "From Raw to Refined: How Data Transformations Shape Effect Sizes and Reliability"

#openscience #neuroskyence
lauraklatt.bsky.social
Laura-Isabelle Klatt @lauraklatt.bsky.social · 22d
This is the line-up 👇We‘ll cover recent result from #EEGManyLabs & #EEGManyPipelines as well as ongoing projects from @scone-neuro.bsky.social and @igor-dgps.bsky.social ! Join us tomorrow at #ICON2025 - 13:45 in room Boavista!
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Reposted by Janik Goltermann
parkvillegeek.bsky.social
Marc L Seal @parkvillegeek.bsky.social · 27d
Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | bioRxiv www.biorxiv.org/content/10.1...
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Reposted by Janik Goltermann
chrisaikenmd.bsky.social
Chris Aiken, MD @chrisaikenmd.bsky.social · 22d
What prevents suicide in #bipolar disorder?

Lithium, then to a lesser degree valproate, but not antipsychotics (unless as augmentation), concludes new cohort study of 44,694 from Korea:
pubmed.ncbi.nlm.nih.gov/40930182

Evidence grade: Low (4/10)
chrisaikenmd.com/ebm/

#psychiatry
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Reposted by Janik Goltermann
russpoldrack.org
Russ Poldrack @russpoldrack.org · 21d
Strategies for effective coding agent usage - the latest in my Better Code, Better Science series russpoldrack.substack.com/p/strategies...
Strategies for effective coding agent usage
Better Code, Better Science: Chapter 5, Part 4
russpoldrack.substack.com
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Reposted by Janik Goltermann
hmarusak.bsky.social
Hilary Marusak, PhD @hmarusak.bsky.social · Jun 30
🚨 New paper in @npp-journal.bsky.social! We combined data from 3 studies (including an SSRI RCT) to explore how endocannabinoids relate to anxiety & treatment response in kids + teens. Team science w/ Jeanne Barcelona, Jeffrey Strawn & more!

www.nature.com/articles/s41...

@wsuthinklab.bsky.social
Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors - Neuropsychopharmacology
Neuropsychopharmacology - Circulating endocannabinoids in children and adolescents: associations with anxiety and the impact of selective serotonin reuptake inhibitors
www.nature.com
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Reposted by Janik Goltermann
jordacular.bsky.social
Jordan McCall @jordacular.bsky.social · 25d
Happy to share our recent work attempting to better understand the impact of early life maternal separation on locus coeruleus function. Super proud of first author (the now Dr.) Chayla Vazquez. She brought this idea when she joined in… March 2020… and she carried it through these rough few years!
npp-journal.bsky.social
Neuropsychopharmacology @npp-journal.bsky.social · 28d
#ThisWeekInNPP

Early life stress profoundly impacts the 🧠 & can result in negative affective behaviors well into adulthood

Here, maternal separation stress produced dysregulated noradrenergic activity in the locus coeruleus (LC) across the lifespan, disrupting LC regulation of coping strategies
Maternal separation disrupts noradrenergic control of adult coping behaviors - Neuropsychopharmacology
Neuropsychopharmacology - Maternal separation disrupts noradrenergic control of adult coping behaviors
www.nature.com
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Reposted by Janik Goltermann
aufdroeseler.bsky.social
Lukas Röseler @aufdroeseler.bsky.social · May 13
Just a friendly reminder to check who owns the preprint servers that you are using and to choose a non-commercial one: en.wikipedia.org/wiki/List_of...
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
Huge thanks to all involved, including: @smeinert.bsky.social @kflinkenfluegel.bsky.social @lisaleehr.bsky.social @jboehnlein.bsky.social @mariusgruber.bsky.social @kabro.bsky.social @vincenthammes.bsky.social @straubeb.bsky.social @nilsopel.bsky.social and everyone at @traplabms.bsky.social
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
Our work adds to previous prominent contributions that question replicability in neuroimaging (e.g., @smarek0502.bsky.social and @tervoclemmensb.bsky.social in @nature.com - doi.org/10.1038/s415...)
Reproducible brain-wide association studies require thousands of individuals - Nature
Combined data from three large studies, with a total sample size of around 50,000 individuals, indicate that many previous studies linking the brain to complex phenotypes have been...
doi.org
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
The original finding of gray matter correlates of maltreatment has been published numerous time and is often described as established. Our consistent null results challenge that view and raise broader questions: how replicable are results in mental health neuroimaging?
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
Similar results were seen when rerunning all analyses using parcellation-based measures of regional cortical thickness/surface and subcortical volumes
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
Largest effects were found in models including HC and MDD groups while not controlling for diagnostic group (model 2 and 13) but disappeared when diagnosis was accounted for
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
The significance of voxel overlap (i.e., replicability) was tested using permutations, resulting in no above-chance replicability across any pairwise or triple-wise cohort combination in any analysis (also when using p<.01 uncorrected)
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
Replicability was defined as the same voxel showing significance across cohorts. At p<.001 uncorrected (a liberal significance treshold for voxel-wise data) only two analyses resulted in minor overlap - k=2 and k=3 voxels. My personal favorite results item, Table 3:
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janikgoltermann.bsky.social
Janik Goltermann @janikgoltermann.bsky.social · 21d
We ran over 100 analyses in each of the 3 cohorts:
➡️different maltreatment operationalizations (subtypes, severe forms, etc)
➡️healthy and clinical (MDD) subsamples
➡️varying inclusion of confounders (diagnosis)
➡️sex-stratified analyses
➡️different gray matter methods (VBM and parcellation-based)
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