Great to see this published after the hard work in Stockholm and Cape Town! How should we think about aerosol detection of #tuberculosis? Is it a diagnostic test? Could it help us prioritize prevention activities? Much more work to do, but exciting nonetheless @climeresearchgroup.bsky.social @ki.se

So...what would happen to the global TB epidemic if we hypothetically "eliminated" undernutrition? In this preprint, we combined estimates from our new review (doi.org/10.1093/ije/...) with population-specific BMI distributions to find out...(doi.org/10.1101/2025...)

Although several AI algorithms can interpret chest x-rays for TB, we still do not have validated or approved CAD products for children. With @jaseddon.bsky.social and colleagues, we shared our thoughts on how to advance CAD for #pediatricTB:

www.thelancet.com/journals/lan...

#tbsky #idsky

A clinical practice guideline for tuberculous meningitis

Tuberculous Meningitis International Research Consortium

www.thelancet.com/journals/lan... 🔒

Meet the antivax whisperer trying to turnaround Britain's child vaccine slump one family at a time. How does she do it? What does she say?

Interview with Professor Elizabeth Whittaker:
www.thetimes.com/article/26a8...

Impact of puberty on immune responses to Mycobacterium tuberculosis in South African adolescents

✅ Just Accepted
#IDSky

Loads of amazing colleagues have contributed to this review of the management of individuals exposed to MDR/RR-TB. www.thelancet.com/journals/lan...

TB seems to comprehensively disrupt the normal physiological progression of puberty.

academic.oup.com/jid/advance-...

Risk of tuberculosis infection in young children exposed to multidrug-resistant tuberculosis in the TB-CHAMP multi-site randomised controlled trial

✅ Just Accepted
#IDSky

Brilliant work by @cfmcquaid.bsky.social and Matt Saunders!

Their updated analysis— a MOUNTAIN of work— shows that an increase in 1 unit of BMI reduces TB risk by 12.3%.

@theunion-tblh.bsky.social @jasonandrews.bsky.social @madhupai.bsky.social

Link: papers.ssrn.com/sol3/papers....

In the endTB trial, researchers assessed the efficacy and safety of five 9-month, all-oral treatment regimens, as compared with the evolving standard of care, in participants with rifampin-resistant, fluoroquinolone-susceptible tuberculosis. nej.md/3WFFJTv

#MedSky #IDSky

Interesting paper published today in Chest, led by Cheng Chen and Leo Martinez. High frequency of reversions observed when serial QTF is performed. Reversion rates decreased with time from exposure and at older ages. Data from 4 different countries

@chest

linkinghub.elsevier.com/retrieve/pii...

Proud to see the endTB trial, work of a huge team, led by @partnersinhealth.bsky.social, @msf.org, IRD & supported by @unitaid.bsky.social, published in @nejm.org today. Safe, effective, shortened treatments for drug-resistant TB can be available to all. #TBSky #ForeignAid tinyurl.com/NEJM-endTB

Happy to have been part of the mammoth team effort reviewing and modelling the burden of TBM in children #TBsky www.sciencedirect.com/science/arti...

Nice to see VQUIN and TB-CHAMP finally out. Both studies evaluated levofloxacin (compared w/placebo) as preventive treatment for MDR TB contacts.
Meta-analysis showed 60% reduction: evidence.nejm.org/doi/full/10....
Each study:
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

Thanks Patrick. All a bit unclear. Probably a combination of better diagnostics in adults meaning that children less exposed, and really thorough screening at baseline to exclude any hint of early disease. I think that some of the efficacy seen in most TPT trials is in treating early disease.

Thanks Tom. I suspect that the better you make the baseline screening, the less effective the TPT becomes as you identify and exclude very early disease which is probably what most TPT is treating. But yes, for me, I will give levofloxacin to children <5 years exposed to MDR-TB. Adults, hmmm.

And finally the meta-analysis of the two trials in NEJM Evidence with a nice article on the world's weird obsession with P values.

evidence.nejm.org/doi/full/10....
evidence.nejm.org/doi/full/10....

Also out in this issue of NEJM. Results from the VQUIN trial. www.nejm.org/doi/full/10....

This journey began for me in 2009. Beyond excited to see this now out in print. Thank you to everyone (a very large cast) who made this happen. www.nejm.org/doi/full/10....

A reminder on #WorldChildrensDay that 1.3million children fell ill with #tuberculosis in 2023, causing 200,000 paediatric deaths from a disease that's curable & preventable.

Govts & funders must urgently prioritise children in research funding & program implementation. msfaccess.org/tactic-test-...