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jasonyanglab.org
Jason Yang
@jasonyanglab.org
5.4K followers 1.7K following 73 posts
Assistant Professor at Rutgers New Jersey Medical School | Systems Biology, Synthetic Biology, Machine Learning, Antibiotic Resistance, Tuberculosis, Heart Failure, Immunoengineering
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jasonyanglab.org
Jason Yang @jasonyanglab.org · 8d
Very happy to share some more good news. Our collaboration with Jeffrey Boyd's lab is now published at J Inorganic Biochemistry! Here, Jeff found that iron limitation reprograms S. aureus metabolism towards fermentation. We're grateful to be part of this study.

www.sciencedirect.com/science/arti...
Fermentative growth decreases the iron demand of Staphylococcus aureus
Iron (Fe) is an essential nutrient for S. aureus survivability and pathogenesis, but excess Fe can catalyze the formation of toxic oxygen radicals, em…
www.sciencedirect.com
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jasonyanglab.org
Jason Yang @jasonyanglab.org · 22d
Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!

www.pnas.org/doi/abs/10.1...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
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Reposted by Jason Yang
michaelmanhart.bsky.social
Michael Manhart @michaelmanhart.bsky.social · Sep 2
I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share!
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Sep 2
I'm pleased to share that the preprint for our collaboration study on MIS-C in pediatric COVID-19 patients is now available on medRxiv. In this study led by Marila Gennaro at Rutgers NJMS, we report that antibody repertories vary with clinical presentation of COVID-19 in children.
medrxivpreprint.bsky.social
medRxivpreprint @medrxivpreprint.bsky.social · Jul 23
Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection https://www.medrxiv.org/content/10.1101/2025.07.22.25331300v1
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Aug 8
It's nearing the end of the summer and our undergrads have been presenting on their research at their respective summer research symposia. Terrific work by Jonah Simone at the Rutgers Health BMIHAI Symposium and Gianna Elie at the NJMS URSE Symposium!
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Aug 1
I'm excited to share that we've received a NIBIB Trailblazer Award to advance our work on engineering therapeutic macrophages! Grateful for our team and excited to launch this collaboration with the Caleb @bashorlab.bsky.social at Rice!
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jul 31
Many thanks to ScienceNews.dk for highlighting our work!
Stressed bacteria develop antibiotic resistance more easily
When bacteria are under energy stress – burning more energy than they produce, it increases their chances of developing antibiotic resistance. A new study offers new insight into how antibiotic...
sciencenews.dk
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 26
Thank you @njmicrobe.bsky.social for this really nice writeup about our work!
njmicrobe.bsky.social
Theobald Smith Society @njmicrobe.bsky.social · Jun 26
Bacteria under energy stress evolve antibiotic resistance faster. New work from Jason Yang’s lab, Rutgers shows how ATP imbalance drives mutagenesis, ROS production, and persistence. A big leap in understanding AMR. go.njmicrobe.org/Fs4R5J #AMR #Microbiology #JasonYang #Rutgers #AntibioticResistance
Fueling the Fight: How Bacterial Metabolism Drives Antibiotic Resistance and Persistence
The global rise of antimicrobial resistance (AMR) is a daunting challenge for modern medicine, directly contributing to over a million deaths in 2019 alone. Understanding the complex ways bacteria eva...
go.njmicrobe.org
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Reposted by Jason Yang
natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · Jun 18
A study in Nature Communications shows that constitutive hydrolysis of ATP and NADH, or ‘bioenergetic stress,’ potentiates the evolution of antibiotic resistance and persistence in E. coli. #medsky 🧪
Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis of ATP and NADH (or ‘bioenergetic stress’) potentiates the evolution of antibiotic resistance and persistence in E. coli.
go.nature.com
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 11
@rutgersu.bsky.social published a very nice article about our work!

www.rutgers.edu/news/rutgers...

@njms-mdphd.bsky.social
Rutgers Health Research Identifies New Trigger Accelerating Antibiotic Resistance
New Jersey Medical School study finds metabolic stress drives antibiotic tolerance and speeds resistance.
www.rutgers.edu
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Many thanks to many members of the Yang Lab who contributed to this project (including many undergrads!) and to our collaborators Douglas McCloskey and Xiaoyang Su! 11/11

@njms-mdphd.bsky.social
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
We're eager to explore these topics in future projects and to see how generalizable these phenotypes are to pathogenic E coli and other species. We think these mechanisms may inform design of antibiotic adjuvants that can slow or prevent resistance development. 10/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Importantly, little is known on how energy balance alters bacterial physiology. Although metabolic stress is known to inhibit growth and enhance metabolism, our work is the first to study stress responses and antibiotic phenotypes caused by disrupted energy balance. 9/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
By developing a new assay, Barry showed that mismatches between ATP utilization and production (disrupting ATP homeostasis) are sufficient for augmenting antibiotic killing. Thus, Barry's work introduces new concepts in understanding the interplay between energy balance and antibiotic efficacy. 8/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Using bacterial genetics approaches, Barry was able to show that bioenergetic stress mechanistically induces stress responses that increase antibiotic stress-induced mutation rates and that protect against antibiotic killing. 7/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
This was also surprising that we previously showed that high levels of reactive oxygen species (ROS) were associated with high antibiotic killing, but the pF1 and pNOX cells had decreased killing while also possessing high levels of ROS! 6/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Correlations between ATP availability and persistence are known and are usually thought about as correlations between metabolic activity (e.g., dormancy, low ATP) and killing efficacy. But Barry's cells have HIGH metabolic activity, which we previously found to INCREASE antibiotic killing. 5/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Surprisingly, Barry found that bioenergetically stressed cells evolve antibiotic resistance FASTER than control cells (!!) and are also in general protected from bactericidal antibiotic stress (persistence). 4/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
These strains constitutively hydrolyze ATP (pF1) or NADH (pNOX), creating ATP or NADH sinks in these cells. These in turn induce 'bioenergetic stress' in which the cells are always struggling to meet their energetic demands. 3/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
Barry generated a genetic model system (frequently used by the metabolic engineering community) involving E coli cells over-expressing ATP synthase F1 complex genes (pF1) or heterologously expressing NADH oxidase from Streptococcus (pNOX). 2/n
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jasonyanglab.org
Jason Yang @jasonyanglab.org · Jun 9
I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n

www.nature.com/articles/s41...
Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis...
www.nature.com
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jasonyanglab.org
Jason Yang @jasonyanglab.org · May 14
Honored to receive this year's Young Investigator Award from our local ASM branch!
njmicrobe.bsky.social
Theobald Smith Society @njmicrobe.bsky.social · May 14
Congrats to Dr. Jason Yang, winner of the 2025 TSS Young Investigator Award! His work at Rutgers uses machine learning & systems biology to tackle AMR, TB & more. A rising leader in biomedical science. Read more here: wix.to/tL2l4fi #Leadership #Microbiology #Innovation #SystemsBiology #Rutgers
Honoring Innovation and Resilience: Dr. Jason Yang Receives the 2025 Theobald Smith Young Investigator Award
The Theobald Smith Society is proud to present the 14th Young Investigator Award to Dr. Jason H. Yang, Assistant Professor and Chancellor Scholar at Rutgers New Jersey Medical School. A rising star in...
wix.to
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jasonyanglab.org
Jason Yang @jasonyanglab.org · May 14
Yang Lab had a terrific time at Rutgers' Biomedical Health Informatics and Artificial Intelligence Symposium yesterday. Great jobs by Yiqi Yan, Oliver Gu, and Reuven Rosen who presented on their work!
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jasonyanglab.org
Jason Yang @jasonyanglab.org · May 6
Our undergraduate machine learning maestro Edson Petry gave a terrific research presentation this afternoon at the Rutgers Pathways for Junior Scientists Research Program! #Rutgers #NJMS
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jasonyanglab.org
Jason Yang @jasonyanglab.org · May 4
Would you mind adding me too please? Thanks in advance!
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