Jonathan Dushoff
@jdushoff.bsky.social
1K followers 140 following 300 posts
Theoretical biologist, recreational mathematician, anti-fascist*. * I had planned not to be political here, but when circumstances change, decisions sometimes have to change.
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jdushoff.bsky.social
The fact that the 6 L (leucine) codons come together to form an L should be interpreted as a sign that this is a good way to visualize the aa table. 🙂

8/8
jdushoff.bsky.social
The two arginine blocks are in the same quadrant, but farther apart than might be expected, because the first-position change is a transversion not to a bond-partner, and because pyrimidines are over-represented in P1, and purines are over-represented in P3, of R codons.

7/8
jdushoff.bsky.social
Dashed yellow lines link unconnected blocks that represent the same aa. The two serine blocks are in different quadrants because serine has two different P2 nts, which is pretty weird.

6/8
jdushoff.bsky.social
Arrows indicate potential CpG bridge codons. Each large arrow indicates four codons that can bridge back to an earlier codon. Small arrows each indicate one codon that can bridge forward. The top row should also have small forward arrows, but mysteriously does not. We blame the gremlins.

5/8
jdushoff.bsky.social
Circles indicate codons with CpG. The large circle indicates all four codons in the CGX box; each small circle indicates a single codon.

4/8
jdushoff.bsky.social
So, for example, V (valine) is in the T quadrant, and the G section of that quadrant, corresponding (since the top-level T represents) to GTX. W (tryptophan) is in the G quadrant, T section, G subsection, corresponding to TGG

3/8
jdushoff.bsky.social
nts for all three codon positions are arranged in this pattern. Position-two (P2) nts have the largest effect on aa, and determine quadrant of each codon. P1 nts are nested inside the P2 quadrants. P3 nts are nested inside P1; these lines are not shown if they don't affect aa result.

2/8
jdushoff.bsky.social
Working with @rowandurrant.bsky.social on ways to visualize the amino-acid table and better understand viral evolution.

We started with a two-by scheme for nucleotides (small square), where bond partners are horizontally adjacent and transition-connected nts are vertically adjacent.

1/8
A blackboard with a drawing in several colors of chalk showing 16 squares, some subdivided, with one-letter abbreviations for amino acids and other annotations. Above is a small white square divided in four, showing ATCG (clockwise from upper left). More description provided in the thread.
jdushoff.bsky.social
The #DAIDD2025 deadline has been extended to 10 Oct!
jdushoff.bsky.social
An "dynamic" workshop with an exciting group in a fun place!

docs.google.com/document/d/e...
A screenshot of a flyer with a picture of Muizenberg beach with changing sheds in the foreground and the Cape of Good Hope in the background; some text information similar to the information in the link; and logos from SACEMA and ICI3D.
jdushoff.bsky.social
bsky needs "like" options like fb has, so I can just click laugh. Never needed that so much as now.
Reposted by Jonathan Dushoff
joesudbay.bsky.social
Nick Valencia, who has been doing amazing reporting, just wrote about this:

“These Are Abductions.” Newlywed Husband Says Wife Taken During Green Card Interview

open.substack.com/pub/nickvale...
jdushoff.bsky.social
*no competent federal prosecutor with principles and a spine would bring such charges.
jdushoff.bsky.social
It's pretty likely that the phrase surrounding it is awkward or ambiguous, try rewriting a bit around it?
Reposted by Jonathan Dushoff
lshtm.bsky.social
Missed out on a ticket for LSHTM’s Health Misinformation UNPACKED?

Our event is proving so popular we’ve released EXTRA online tickets so more people can learn how to fight dangerous health #misinformation!

Get your ticket👉 www.lshtm.ac.uk/newsevents/e...
jdushoff.bsky.social
This cartoon from October 1953 reminds me of something. Or someone.
Peanuts cartoon strip

Panel 1: Patty and Violet are smiling at Charlie Brown, who says "Go ahead! Make fun of me! You just wait.

Panel 2: Charlie Brown shakes his fist in foreground, girls play in background. He says "Someday I'll get to be President, and then you'll all be sorry!"

Panel 3: Girls say in unison: "I'll say we will!"

Panel 4: Charlie Brown walks down the sidewalk saying "Somehow that didn't come out right."
jdushoff.bsky.social
So to be clear. If it happened 365 days ago, you would say "it happened two years ago today"? Because that's two "occurences of the day"? That's (effectively) where this thread started, and not very far up that page.
Reposted by Jonathan Dushoff
scottpegan.bsky.social
The Dept. of BioSciences at #RiceUniversity, in Houston, Texas, invites applications for a tenure-track assistant professor position in Evolutionary Biology, with a preferred focus on organismal responses to environmental change. Please RT!

Apply: apply.interfolio.com/173889
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