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jenswalter15.bsky.social @jenswalter15.bsky.social · 15d

Multicenter RCT in @lancetgastrohep.bsky.social:
FMT (with live microbes) prevents recurrent C. diff far better than fecal filtrates.
Thanks to Dina Kao (@ualberta.bsky.social) & @tsbschm.bsky.social from
@apcmicrobiomeirel.bsky.social), and whole team.
🔗 authors.elsevier.com/c/1lphg8nByr...

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jenswalter15.bsky.social @jenswalter15.bsky.social · Aug 23

How has obesity treatment evolved, and where is it heading?
Our new review in Obesity explores:
✔ The central role of nutrition
✔ Precision medicine & microbiome strategies
✔ Integration with emerging therapies
Read here onlinelibrary.wiley.com/doi/full/10....
#Obesity #Nutrition #PrecisionMedicine

Evolution of multidisciplinary obesity treatments: past, present, and future role of nutrition

Obesity is a complex chronic disease requiring lifelong comprehensive treatment. In addition to lifestyle counseling that improves nutrition and physical activity, a promising new generation of obesi...

onlinelibrary.wiley.com

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jenswalter15.bsky.social @jenswalter15.bsky.social · Aug 14

I joined Dr. Karan Rajan to talk about the science of the gut microbiome, how it’s changed through industrialisation, how we can restore it, and the NiMe diet.

Grateful, and humbled, to discuss the #microbiome on a channel with 2M followers.

🎥 Watch here: www.youtube.com/watch?v=sb4d...

The NiMe Diet - Eat Like Our Ancestors For Better Gut Health

YouTube video by Dr Karan

www.youtube.com

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jenswalter15.bsky.social @jenswalter15.bsky.social · Apr 24

With big thanks to @isappscience.bsky.social for organizing the podcast and to @colinhillucc.bsky.social and Daniel Trancredi for being great hosts and for asking very interesting questions.

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jenswalter15.bsky.social @jenswalter15.bsky.social · Apr 24

Great podcast with Anissa Armet PhD RD on our recent @cellpress.bsky.social about the 'Non-industrialized Microbiome Restore (NiMe) Diet'. Covers a lot of the science, but also how Anissa's personal journey with IBD inspired both the research and the diet itself.

The International Scientific Assoc for Probiotics & Prebiotics @isappscience.bsky.social · Apr 24

Have you seen the hot-off-the-press "NiMe Diet" paper? Dr. Anissa Armet PhD RD explains the study in this edition of the podcast. (Plus, see the show notes for the NiMe Diet cookbook with the study's high-fiber recipes!)

isappscience.org/episode-55-h...

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jenswalter15.bsky.social @jenswalter15.bsky.social · Apr 14

Grateful to @natrevgastrohep.nature.com and Jordan Hindson for highlighting our recent @cellpress.bsky.social study on #microbiome restoration.

Great to see our work featured in the Research Highlights section.

📄 Read the original paper: www.cell.com/cell/fulltex...

#MicrobiomeResearch #GutHealth

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jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 25

Thank you to Dalimil Bujdos and Paul O'Toole from @ucc.ie, @uccmicrobiology.bsky.social, and @apcmicrobiomeirel.bsky.social for a fun collaboration that continues to teach me a lot.

jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 25

aurora was validated on model species. For example, differences in host predictions and proportion of autochthonous strains differ vastly between strictly host-adapted Limosilactobacillus reuteri and nomadic Lactiplantibacillus plantarum.

genomebiology.biomedcentral.com/articles/10....

aurora: a machine learning gwas tool for analyzing microbial habitat adaptation - Genome Biology

A primary goal of microbial genome-wide association studies is identifying genomic variants associated with a particular habitat. Existing tools fail to identify known causal variants if the analyzed ...

genomebiology.biomedcentral.com

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jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 25

It is hard to determine habitat adaptations in host-associated bacteria, e.g. because strains might be allochthonous or mislabeled. Here we present aurora, a gwas tool that identifies autochthonous strains and the genes associated with their habitats.

doi.org/10.1186/s130...

aurora: a machine learning gwas tool for analyzing microbial habitat adaptation - Genome Biology

A primary goal of microbial genome-wide association studies is identifying genomic variants associated with a particular habitat. Existing tools fail to identify known causal variants if the analyzed ...

doi.org

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jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 24

I have been teaching classes on the gut #microbiome for almost 20 years and always struggled to have a good book to recommend. Finally there is one. Fergus Shanahan's "Fast Facts: The Gut Microbiome" provides expert insight, is brilliant, and it is free.

doi.org/10.1159/isbn...

Fast Facts: The Gut Microbiome

‘Fast Facts: The Gut Microbiome’, though pithy and concise, is amazingly comprehensive and takes the reader through all major aspects of the human gut micr

doi.org

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jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 3

Register here for free tickets to the book launch with the Creators, March 10th, Lapps Quay, Cork, Ireland. bit.ly/3EVxa15

Find us on Instagram and Facebook under
@nimediet.

Microsoft Forms

bit.ly

jenswalter15.bsky.social @jenswalter15.bsky.social · Mar 3

Eat to support your #microbiome. Anissa Armet and I are thrilled to announce our FREE 'science cookbook' on The NiMe Diet, bit.ly/41BV0HW, covering the story behind our research published in @cp-cell.bsky.social. If around Cork, register freely for an evening with the Creators on March 10th.

The NiMe Diet: Scientific Principles and... | ERA

Industrialized diets – high in processed foods and low in fibre – disrupt the gut microbiome and predispose us to chronic diseases, such...

bit.ly

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jenswalter15.bsky.social @jenswalter15.bsky.social · Feb 28

I am indebted to the two co-leads, Dale Archer and Maria Elisa Perez-Munoz, the students and staff that helped with the experiments, and the many esteemed collaborators that contributed to this work.

jenswalter15.bsky.social @jenswalter15.bsky.social · Feb 28

We think this work is important as it shows that even a bacterial species considered beneficial can have negative long-term effects on autoimmunity, and it establishes a molecular foundation for strain-specific differences. Relevant for the development of microbial therapeutics.

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jenswalter15.bsky.social @jenswalter15.bsky.social · Feb 28

We found considerable strain-level differences in the effects of L. reuteri to cause spontaneous RR-EAE. R2lc, a strain that activates AhR through the pks gene cluster, resulted in severe EAE, while a pks mutant of R2lc and a pks-negative strain (PB-W1) failed to exacerbate EAE.

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jenswalter15.bsky.social @jenswalter15.bsky.social · Feb 28

Very much to our surprise, a strain of Limosilactobacillus reuteri drives severe pathology in a mouse model of multiple sclerosis. Pathology was driven by a secondary metabolite that hyperactivates the AhR receptor. See our publication in Cell Reports.

www.sciencedirect.com/science/arti...

A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis

Limosilactobacillus reuteri is an immunomodulatory bacterium enriched in non-industrialized microbiomes, making it a therapeutic candidate for chronic…

www.sciencedirect.com

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Reposted

Research Ireland @researchireland.ie · Feb 5

A new study led by Prof Jens Walter of @apcmicrobiomeirel.bsky.social reveals that a newly developed diet, inspired by the eating habits of non-industrialized societies, can significantly lower the risk of several chronic diseases. Read more here: www.researchireland.ie/news/non-ind...

A woman places lunch boxes in a fridge filled with fruits and vegetables

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jenswalter15.bsky.social @jenswalter15.bsky.social · Feb 13

Thank you to @naturerevmicro.bsky.social and Agustina Taglialegna for highlighting our work on microbiome restoration and the NiMe diet. Really nice summary.

Nature Reviews Microbiology @natrevmicro.nature.com · Feb 10

New online! A gut microbiome-restoring diet

A gut microbiome-restoring diet

Nature Reviews Microbiology, Published online: 10 February 2025; doi:10.1038/s41579-025-01161-2In this study, Li et al. perform a randomized controlled feeding trial to test the effects of a microbiome restoration strategy on gut microbiome features, host…

www.nature.com

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jenswalter15.bsky.social @jenswalter15.bsky.social · Jan 28

Really nice to see my alma mater, @unihohenheim.bsky.social,
post about our recent study in @cellpress.bsky.social. I spent most of my student years there (they have a historic park and a castle). Big thanks also to Stephan Bischoff and Dr. Benjamin Seethaler for another great collaboration.

Universität Hohenheim @unihohenheim.bsky.social · Jan 28

Ursprüngliche, nicht-industrialisierte #Ernährung senkt Risikofaktoren für #HerzKreislaufErkrankungen und #Diabetes, so eine Studie mit Beteiligung der #UniHohenheim: Restore-Diät senkt Gewicht, Cholesterin, Blutzucker und Entzündungswerte. Publikation in #Cell

Pressemitteilung: sohub.io/mlia

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jenswalter15.bsky.social @jenswalter15.bsky.social · Jan 24

Thank you @erictopol.bsky.social for highlighting our work.
For those interested cooking some yummy healthy dishes that feed the #microbiome, all the recipes that were used in this human intervention trial are freely available on our instagram page.

www.instagram.com/nimediet/

Eric Topol @erictopol.bsky.social · Jan 23

The impact of a non-industrialized ("Restore") diet plus a key microbe on improving cardiometaboiic health markers and reducing body-wide inflammation, from a randomized trial
www.cell.com/cell/fulltex... @cellpress.bsky.social open-access

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Reposted

Nature Reviews Microbiology @natrevmicro.nature.com · Jan 24

#weekendreading🔬

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

@cellpress.bsky.social
#microsky #microbiome #diet

www.cell.com/cell/fulltex...

Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation

Is it possible to restore the human gut microbiome in industrialized settings and reintroduce microbial species that have been lost? In healthy adults, Li et al. found that consuming a diet mimicking ...

www.cell.com

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Reposted

Ran Blekhman @blekhman.bsky.social · Jan 22

Today we report a new compendium of human gut microbiomes with >168,000 samples

By analyzing this massive dataset, we discovered distinct microbiome patterns across the globe, and show we can predict where a person lives just from their gut bacteria

Now out in Cell:

www.cell.com/cell/fulltex...

Integration of 168,000 samples reveals global patterns of the human gut microbiome

The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...

www.cell.com

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jenswalter15.bsky.social @jenswalter15.bsky.social · Jan 23

Big thanks also to the Weston Family Microbiome Initiative, PrecisionBiotics (now Novonesis), and @researchireland.bsky.social for funding, and @ualberta.bsky.social, @ucc.bsky.social, @apcmicrobiomeirel.bsky.social and all institutions involved for their support.

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jenswalter15.bsky.social @jenswalter15.bsky.social · Jan 23

Deeply indebted to the many brilliant collaborators and team members that contributed to this research. This was a team effort! Thanks to Fuyong Li and Anissa Armet for great teamwork as co-first authors, and Carla Prado for supervision of the project in Alberta after I left.

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jenswalter15.bsky.social @jenswalter15.bsky.social · Jan 23

Given the rather exciting clinical effects, we decided to give this diet a name: Non-industrialized Microbiome Restore (NiMe™) Diet.

Recipes used in this trial, and additional information, are or will be freely available here: instagram.com/nimediet/

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