Jesus Alvarado-Valverde
@jesusav.bsky.social
(He/Him)
Science - Biology - Evolution
Postdoctoral researcher at IMB, Mainz
Protein bioinformatics:
AlphaFold, PPIs and motif research
Science - Biology - Evolution
Postdoctoral researcher at IMB, Mainz
Protein bioinformatics:
AlphaFold, PPIs and motif research
Pinned
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
During host cell invasion, Toxoplasma mimics the FFAT motif and repurposes it to associate its parasitophorous vacuole to the endoplasmic reticulum!
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
Reposted by Jesus Alvarado-Valverde
Really important discussion also applicable to UK research funding: the application system is enormously wasteful of time, energy and talents
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…
medium.com
December 6, 2025 at 1:21 PM
Really important discussion also applicable to UK research funding: the application system is enormously wasteful of time, energy and talents
During host cell invasion, Toxoplasma mimics the FFAT motif and repurposes it to associate its parasitophorous vacuole to the endoplasmic reticulum!
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
December 8, 2025 at 2:38 PM
During host cell invasion, Toxoplasma mimics the FFAT motif and repurposes it to associate its parasitophorous vacuole to the endoplasmic reticulum!
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
I'm happy to have been part of this work! Congratulations to Chahat Mehra and Lena Pernas for all the hard work!
www.nature.com/articles/s41...
Reposted by Jesus Alvarado-Valverde
#NewResearch
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
Toxoplasma effector TgROP1 establishes membrane contact sites with the endoplasmic reticulum during infection - Nature Microbiology
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
www.nature.com
November 26, 2025 at 3:51 PM
#NewResearch
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
The Toxoplasma gondii effector TgROP1 mimics host factors to bind VAPA/B, thereby establishing parasite–host ER contact sites.
#MicroSky 🦠
www.nature.com/articles/s41...
Check out our latest research!
Using a motif predictor and AlphaFold models, we designed experiments to validate their interaction interfaces and tested the effects of uncharacterized variants on binding, then predicted the effects of hundreds of them.
www.biorxiv.org/content/10.1...
Using a motif predictor and AlphaFold models, we designed experiments to validate their interaction interfaces and tested the effects of uncharacterized variants on binding, then predicted the effects of hundreds of them.
www.biorxiv.org/content/10.1...
Variant characterization in the intrinsically disordered human proteome
Variant effect prediction remains a key challenge to resolve in precision medicine. Sophisticated computational models that exploit sequence conservation and structure are increasingly successful in t...
www.biorxiv.org
July 1, 2025 at 9:04 AM
Check out our latest research!
Using a motif predictor and AlphaFold models, we designed experiments to validate their interaction interfaces and tested the effects of uncharacterized variants on binding, then predicted the effects of hundreds of them.
www.biorxiv.org/content/10.1...
Using a motif predictor and AlphaFold models, we designed experiments to validate their interaction interfaces and tested the effects of uncharacterized variants on binding, then predicted the effects of hundreds of them.
www.biorxiv.org/content/10.1...
Reposted by Jesus Alvarado-Valverde
Remember to tune it at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvarado-Valverde (@jesusav.bsky.social).
Register to attend:
tinyurl.com/PMCseminar2
Register to attend:
tinyurl.com/PMCseminar2
May 9, 2025 at 2:19 PM
Remember to tune it at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvarado-Valverde (@jesusav.bsky.social).
Register to attend:
tinyurl.com/PMCseminar2
Register to attend:
tinyurl.com/PMCseminar2
Reposted by Jesus Alvarado-Valverde
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).
Register to attend:
tinyurl.com/PMCseminar2
(1/2)
Register to attend:
tinyurl.com/PMCseminar2
(1/2)
April 24, 2025 at 5:02 AM
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).
Register to attend:
tinyurl.com/PMCseminar2
(1/2)
Register to attend:
tinyurl.com/PMCseminar2
(1/2)