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Jon Marles-Wright @jmarlesw.bsky.social · 9d

Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...

Characterisation and engineering of thermostable PLP-dependent alpha-oxoamine synthases (AOSs); versatile C-C bond forming biocatalysts

The toolbox of C-C bond forming biocatalysts is forever expanding as demand increases for new and sustainable routes to organic molecules. One class o…

www.sciencedirect.com

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system.
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

Next up, @nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.

blogs.ncl.ac.uk/nickjakubovi...

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

Next introducing Dr Alessandra Dantas.

The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.

@alesdantas.bsky.social

www.ncl.ac.uk/dental/about...

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

Last introduction for the today..

Dr Kesha Josts @kjosts.bsky.social

The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.

www.ncl.ac.uk/cbcb/staff/p...

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Reposted by Jon Marles-Wright

Microbes in Health and Disease @mhd-newcastle.bsky.social · 16d

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.

www.marles-wright-lab.org

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Jon Marles-Wright @jmarlesw.bsky.social · 23d

Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.

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Reposted by Jon Marles-Wright

Kevin Waldron @waldronlab.bsky.social · May 12

Finally, we're recruiting!
If you'd like to do a PhD using NMR structures to study the dynamics of a metalloenzyme, then you're in luck! Come to Warsaw for this project, in collaboration with Simone Ciofi-Baffoni's group at CERM, Florence: ibb.edu.pl/app/uploads/...

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Jon Marles-Wright @jmarlesw.bsky.social · May 12

York Uni campus looking splendid today. Visiting Biology for a viva.

A photograph of the lake at York University looking from Biology

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Jon Marles-Wright @jmarlesw.bsky.social · Apr 25

Happy April 25th to all who observe the perfect date.

a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it

ALT: a man and a woman are talking into microphones and the woman is wearing a sash that says rhode island on it

media.tenor.com

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Jon Marles-Wright @jmarlesw.bsky.social · Apr 8

Interested in Engineering Biology and spending a few days in the best city in the world? Designer Biology 2025 is coming to Newcastle: 29-31st July. Abstracts and registration is open: www.efbiotechnology.org/designerbiol...

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Jon Marles-Wright @jmarlesw.bsky.social · Feb 14

Congratulations!

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Reposted by Jon Marles-Wright

Kate Beckham @kshbeckham.bsky.social · Jan 6

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group.
Deadline end of February.
Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239

PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University on FindAPhD.com

PhD Project - PhD studentship: Structural and functional characterisation of mycobacterial outer membrane proteins at Newcastle University, listed on FindAPhD.com

www.findaphd.com

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Jon Marles-Wright @jmarlesw.bsky.social · Dec 12

Day trip to Sheffield for a very enjoyable encapsulin viva with @perbullough.bsky.social

A picture of the Christmas lights on the Sheffield children’s hospital viewed from Firth Court.

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Reposted by Jon Marles-Wright

RuthLeyMicro @microbiome.bsky.social · Dec 10

Here we delve deeper into what makes a flagellin “silent” - see Michael Bell’s cryo-EM structure of a silent flagellin from the flagellum of Roseburia hominis- it has a different charge distribution compared to FliC and it dissociates rapidly from TLR5 www.biorxiv.org/content/10.1...

Kinetic and structure-based comparisons of silent and stimulatory flagellin interactions with TLR5

The bacterial protein flagellin is the sole ligand of the innate immune receptor Toll-like receptor 5 (TLR5). Flagellins with strong agonism bind TLR5 at their D1 and D0 domains, while poor agonist si...

www.biorxiv.org

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Jon Marles-Wright @jmarlesw.bsky.social · Dec 3

He was saying how much he is enjoying working with you. Just need to get those pesky MTA’s sorted!

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Jon Marles-Wright @jmarlesw.bsky.social · Dec 3

A lovely winter graduation ceremony this afternoon. Posing here with some of the fab students I got to work with on the MRes Biotech and Biodesign last year. Always great to hear what they are all up to now.

A graduation photograph. Smiling graduated and me pictured with purple lighting.

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Reposted by Jon Marles-Wright

Kevin Waldron @waldronlab.bsky.social · Dec 3

I have a PhD position available in my group, to start in March 2025. If you have a keen interest in biochemistry and would like to study an exciting and novel class of copper proteins (aka weird Cu tubes) from bacteria, I'd love to hear from you.
You should apply here: ibb.edu.pl/app/uploads/...

Figure from Vita et al., 2016, Sci Rep: https://www.nature.com/articles/srep39065

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Jon Marles-Wright @jmarlesw.bsky.social · Dec 3

So many delightful details. I love the lava ghosts inside the six.

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Reposted by Jon Marles-Wright

STCmicrobeblog @stcmicrobeblog.bsky.social · Dec 2

#ArchaeaSky
www.nature.com/articles/s41...

Towards a molecular picture of the archaeal cell surface - Nature Communications

The model archaeon Sulfolobus acidocaldarius produces several protein filaments with specialised functions, including flagellum-like archaella, Aap pili, and adhesive threads. Here, the authors descri...

www.nature.com

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Jon Marles-Wright @jmarlesw.bsky.social · Nov 30

Every year Lis crafts amazing cakes for the kids. This year Rory’s cake really is something else!

Lis Lowe @lislowe.bsky.social · Nov 30

The cake is done and ready for tomorrow’s party! We won’t talk about the bit where I iced most of it before I realised it was backwards/upside down and was not a number 6 at all. Fixed with some cake surgery 😅

Cake in the shape of a number 6 with a race track on it and some Mario characters

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Jon Marles-Wright @jmarlesw.bsky.social · Nov 27

Lovely work. Very cool to see them performing so well in vitro.

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Reposted by Jon Marles-Wright

Yu Heng Lau @yuhenglau.bsky.social · Nov 26

Long time lurker, first time poster... announcing our latest preprint on encapsulin protein cages!

We can now assemble them beautifully in vitro, without the ugly defects you get using acid/base or denaturants.
This lets us put any synthetic cargo into these cages.

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Jon Marles-Wright @jmarlesw.bsky.social · Nov 24

Sunday morning crafts with R.

A picture of two cardboard mario kart style karts on a table.

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