John Metzcar
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jmetzcar.bsky.social
John Metzcar
@jmetzcar.bsky.social
53 followers 120 following 6 posts
I make and use dynamic models to help make decisions and understand biology, cancer, and therapies. Currently at the TMDC
@UMNCSE #mathonc #NETs
Posts Replies Media Videos
Reposted by John Metzcar
fabianspill.bsky.social
Congrats Margherita on completing her @physicell.bsky.social model investigating the effect of ECM organisation and remodelling and the interplay with chemotaxis on invasion www.biorxiv.org/content/10.1... Great collaboration with @jmetzcar.bsky.social , @mathcancer.bsky.social and Pradeep
The role of contact guidance and ECM remodelling in cancer invasion: a computational study
The extracellular matrix (ECM) is a complex network of fibrous proteins and other macro-molecules that provides crucial mechanical and biochemical cues that regulate cancer cell invasion and tumour pr...
www.biorxiv.org
September 10, 2025 at 7:03 AM
Reposted by John Metzcar
netrf.org
Be a part of ‪Endocrine Oncology's ‬special collection celebrating the contributions and leadership of women in Neuroendocrine Tumour (NET) research.
Original research, reviews and case reports all welcome!
🔗https://eo.bioscientifica.com/page/Women-in-NETs
Submit your proposal: [email protected]
August 12, 2025 at 8:59 PM
Reposted by John Metzcar
mathcancer.bsky.social
Excited for this @cp-cell.bsky.social article co-led by @fertiglab.bsky.social and Genevieve Stein-O'Brien, on creating a plain language "grammar" to easily write simulation models as virtual laboratories for complex systems like cancer.

Fully open access and open source! 🧪 #mathonco #mathbio
July 29, 2025 at 1:06 AM
Reposted by John Metzcar
labwaggoner.bsky.social
A plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues @cellcellpress.bsky.social @mathcancer.bsky.social
www.cell.com/cell/fulltex...
July 26, 2025 at 8:46 PM
Reposted by John Metzcar
danruderman.bsky.social
Fantastic work, @mathcancer.bsky.social ! phys.org/news/2025-07...
New software simulates cancer cell behavior using genomics and computational models
In the same vein as weather forecast models that predict developing storms, researchers have now developed a method to predict the cell activity in tissues over time. The new software combines genomic...
phys.org
July 25, 2025 at 3:40 PM
Reposted by John Metzcar
inca-netcancerday.bsky.social
Due to early detection of #MultipleEndocrineNeoplasia type 2A (MEN2A), made possible by the genetic test, and the high chance of MTC, surgery to remove the thyroid gland is now done in children who carry the gene.
✅Get informed in 11 languages: incalliance.org/net-info-pac...
#LetsTalkAboutNETs
June 16, 2025 at 6:35 AM
Reposted by John Metzcar
oncothor.bsky.social
Time to rethink our approach to NET grading and use whole slide analysis (WSA) in addition to hotspot analysis (HSA) when assigning tumor grade using Ki-67? It certainly seems so.... @IHC_guy

www.modernpathology.org/article/S089...
Optimal Approaches to Grading Entero-Pancreatic Neuroendocrine Tumors Using Ki-67 Proliferation Index (Hotspot and Whole Slide Digital Quantitative Analysis)
Grading neuroendocrine tumors using Ki-67 PI is essential for prognostic assessment and therapeutic decision-making. However, the absence of standardized guidelines has led to methodological inconsist...
www.modernpathology.org
April 18, 2025 at 12:21 PM
Reposted by John Metzcar
oncothor.bsky.social
Wishing you had access to new and updated guidelines on MEN1...? Worry not, this team has you covered.

www.sciencedirect.com/science/arti...
American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1
This document presents the findings of the American Association of Clinical Endocrinology (AACE) on the diagnosis, management, and surveillance of pat…
www.sciencedirect.com
April 18, 2025 at 12:36 PM
Reposted by John Metzcar
mathonco.bsky.social
Machine learning for model parameterization:
mathematical-oncology.org/blog/machine...

@hamiscalculated.bsky.social @jmetzcar.bsky.social @stolzbernadette.bsky.social
#MathOnco #MachineLearning
BIRS Recap: Machine learning for model parameterization
mathematical-oncology.org
mathematical-oncology.org
April 4, 2025 at 11:00 AM
Reposted by John Metzcar
oncothor.bsky.social
PRRT + PARP inhibitors in advanced NETs? To date, no trials have convincingly shown that PRRT + drug X (whatever that may be) is better than PRRT alone. The addition of PARPi seems to add little early toxicity but larger trials needed to show efficacy.

jnm.snmjournals.org/content/earl...
177Lu-DOTATATE in Combination with PARP Inhibitor Olaparib Is Feasible in Patients with Somatostatin-Positive Tumors: Results from the LuPARP Phase I Trial
This phase I trial aimed to assess the feasibility and toxicity of combining the poly(adenosine diphosphate–ribose) polymerase inhibitor olaparib with 177Lu-DOTATATE in patients with somatostatin rece...
jnm.snmjournals.org
February 28, 2025 at 1:06 PM
Reposted by John Metzcar
adamlmaclean.bsky.social
Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social

(I sure needed an injection of great science in *these times*)

@mathcancer.bsky.social closing out the show...
February 12, 2025 at 7:11 PM
Reposted by John Metzcar
endocrineoncology.bsky.social
Improving #neuroendocrine #tumor treatments with mathematical modeling: lessons from other endocrine cancers
By John Metzcar et al. @kelines.bsky.social
Read it here 👉 https://doi.org/10.1530/EO-24-0025
February 13, 2025 at 12:20 PM