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Reposted by Joel Miesfeld

Anna La Torre @latorrelab.bsky.social · 22d

New preprints from the lab!! (2)

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 22d

Uncoupling Neocortical Neuron Fate and Migration via a Let-7-RBX2 Axis https://www.biorxiv.org/content/10.1101/2025.09.11.675676v1

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Reposted by Joel Miesfeld

Anna La Torre @latorrelab.bsky.social · 22d

🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...

Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development

The Sonic Hedgehog (Shh) signaling pathway is essential for the patterning, growth, and morphogenesis of many tissues. During early eye development, Shh is critical for the formation of the two optic ...

www.biorxiv.org

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Reposted by Joel Miesfeld

Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 21d

Damaged retinal ganglion cells can lead to blindness. MCW’s Dr. Joel Miesfeld is conducting #research into the development of these cells to better identify ways to help them regenerate after damage. Learn more: www.mcw.edu/mcwknowledge...

#Ophthalmology #VisionHealth #MCWKnowledge

Preventing Blindness by Untangling the Genetic Network of Vision Neurons

Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.

www.mcw.edu

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Joel Miesfeld @joelmiesfeld.bsky.social · 22d

A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...

Preventing Blindness by Untangling the Genetic Network of Vision Neurons

Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.

www.mcw.edu

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Reposted by Joel Miesfeld

MCW Graduate Student Association @mcw-gsa.bsky.social · Aug 12

Check out this 40x confocal image of a transgenic zebrafish eye showing UV (red) and blue cones (green), key for color vision. Zebrafish use UV vision for prey detection and navigation!

Got interesting data or images? Send your science with a brief description to be featured!

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Reposted by Joel Miesfeld

Brian Clark @clark-lab-retina.bsky.social · Aug 6

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

PLOS Biology @plosbiology.org · Aug 5

TET enzymes remove #DNAmethylation markers; @ismaelhdeznunez.bsky.social @clark-lab-retina.bsky.social &co show that these enzymes are required for #photoreceptor cells to initiate the genetic program to become rods instead of cones, & for maturation of the #retina @plosbiology.org 🧪 plos.io/3UaVBfl

Left: The active DNA methylation cycle. (i) 5mC is added by DNMTs. (ii) The TET enzymes oxidize 5mC to 5hmC. (iii) 5hmC is converted to 5fC and 5caC by the TET enzymes, followed by conversion back to cytosine by TDG and the base-excision repair pathway. (iv) Alternatively, APOBEC converts 5mC to thymine, causing DNA mismatch. Right: H&E staining of an allelic series of TET conditional P21 mutants.

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MCW Graduate Student Association @mcw-gsa.bsky.social · Aug 5

🎉 MCW grad students: come to the GSA Welcome Social on Aug 22, 5–8 PM at Hoyt Park!
🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes
📝 RSVP by Aug 20 by scanning the QR code!

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Joel Miesfeld @joelmiesfeld.bsky.social · Jul 24

Should have included these two co-organizers in the original post @icanhasmiranda.bsky.social @aoiplab.bsky.social

Joel Miesfeld @joelmiesfeld.bsky.social · Jul 24

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Joel Miesfeld @joelmiesfeld.bsky.social · Jul 24

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Reposted by Joel Miesfeld

Megan Dennis @mydennis.bsky.social · Jul 10

Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers

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Reposted by Joel Miesfeld

Kristen Kwan @blockintheback.bsky.social · Jul 7

🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here:
tol2kitkwan.genetics.utah.edu
Thank you for your patience!!
#zebrafish #transgenesis #plasmids #sharing

tol2kit for kwan lab

tol2kitkwan.genetics.utah.edu

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Reposted by Joel Miesfeld

Wisconsin State Journal @madison.com · Jun 17

Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.

Tom Still: Cancer tests continue to propel Exact Sciences, even in time of research cuts

Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.

madison.com

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Reposted by Joel Miesfeld

MCW Graduate Student Association @mcw-gsa.bsky.social · Jun 16

Meet your 2025–26 GSA Officers & Reps! 👋
We’re here to keep you in the loop, host fun events 🎉, and represent your voice.
Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more!
Got ideas? DM or email us anytime! 😊

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Reposted by Joel Miesfeld

Jeff Farrell @jeffreyafarrell.bsky.social · Jun 13

If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)

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Joel Miesfeld @joelmiesfeld.bsky.social · Jun 5

Congratulations!

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Zebrafish Rock! @zebrafishrock.bsky.social · Jun 2

“Our results suggest that some axons regenerate along tracts of degenerating myelin debris. However, the topography of re-innervation is different after regeneration, suggesting that new axon tracts are created to restore functional vision.”

New work from @pennylamphd.bsky.social et al. 🐠

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 17

See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1

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Reposted by Joel Miesfeld

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 17

See-through science: Danionella cerebrum as a model for neuroregeneration https://www.biorxiv.org/content/10.1101/2025.05.13.653880v1

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Joel Miesfeld @joelmiesfeld.bsky.social · Jun 1

Not sure where the updated form would be located and if it’s different. This was done by our grants administrator but this is the method we used to list the study section preference.

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Joel Miesfeld @joelmiesfeld.bsky.social · Jun 1

I submitted mine through an assignment request form and not the cover letter. grants.nih.gov/grants/how-t... Same information is stated in the cover letter information, which is not always allowed. grants.nih.gov/grants/how-t... I hope this helps.

G.600 - PHS Assignment Request Form

grants.nih.gov

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Reposted by Joel Miesfeld

Jeff Mumm @jsmumm.bsky.social · May 22

Dr. Kevin Emmerich, my former graduate student, will be presenting a summary of his thesis work as a finalist for the 2024 Outstanding Paper Prize from Development. Webinar is next Wednesday, May 28th:

journals.biologists.com/dev/article/...

Development's 2024 outstanding paper prize

We introduced our Outstanding Paper Prize in 2022 (Briscoe et al., 2023). Each year since then, reviewing the papers shortlisted by our editors, and selecting the finalists and overall winner has beco...

journals.biologists.com

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Reposted by Joel Miesfeld

Miranda Scalabrino, PhD @icanhasmiranda.bsky.social · May 16

“Vision Science Team Building” not pictured: Just Dance competition

@joelmiesfeld.bsky.social

Nintendo Switch Sonic Olympics game up on a projector screen with 10 people watching and

Nintendo Switch Mario Kart on a projector screen with 6 people watching and playing

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Joel Miesfeld @joelmiesfeld.bsky.social · May 15

www.nih.gov/news-events/...

Infant with rare, incurable disease is first to successfully receive personalized gene therapy treatment

NIH-supported gene-editing platform lays groundwork to rapidly develop treatments for other rare genetic diseases.

www.nih.gov

Reposted by Joel Miesfeld

Joseph Carroll @aoiplab.bsky.social · May 7

Stop by A0265 today and say hi to @minagaffney.bsky.social - she’s sharing results from our AO corrected visual acuity project, made possible by a collaboration with @roordalab.bsky.social and Will Tuten.

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Joel Miesfeld @joelmiesfeld.bsky.social · May 7

A huge congratulations to Alex Gallo for a fantastic poster presentation today at #ARVO2025 !

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Reposted by Joel Miesfeld

Kristen Kwan @blockintheback.bsky.social · May 5

So thrilled for Emily Woodruff, who just crushed her talk at #ARVO2025

Emily Woodruff giving her talk at #ARVO2025

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