Psychedelics disrupt the link between vascular and neuronal activity, which complicates interpretations of fMRI data. Adopting a more holistic view of what constitutes brain activity may help.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/psychedelics...

🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...

Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of mouse and human brain function

@adamqbauer.bsky.social
@jordacular.bsky.social
@realjoshsiegel.bsky.social
@oliverk28.bsky.social

www.nature.com/articles/s41...

A study in Nature Neuroscience finds psychedelics disrupt the relationship between neuronal activity and blood flow in humans and mice. This suggests fMRI results under psychedelics may reflect vascular effects as much as neural ones and should be interpreted with caution. go.nature.com/47hqVPH 🧪

And the story continues to grow!!!

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬

We found that psilocybin prolongs the neurovascular response, independent of neural activity.

This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging