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Joni Coleman

@jonicoleman.bsky.social

650 followers 610 following 430 posts

Senior Lecturer in Statistical Genetics at KCL. Group GitHub: https://github.com/ColemanResearchGroup/GroupInfoPublic. Views own. He/Him

github.com

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Joni Coleman @jonicoleman.bsky.social · Apr 24

Standard disclaimer: conference bleets are eye-witness accounts and should be treated as such, with all the Loftus effects and reliability concerns that involves: www.scientificamerican.com/article/do-t...

I don't bleet Q&As.

Why Science Tells Us Not to Rely on Eyewitness Accounts

Eyewitness testimony is fickle and, all too often, shockingly inaccurate

www.scientificamerican.com

Joni Coleman @jonicoleman.bsky.social · 28d

Important recent discovery from the Coleman Research Group — a new Coleman to study

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Reposted by Joni Coleman

Kevin Mitchell @wiringthebrain.bsky.social · Sep 7

We're going to see a lot of bullshit in the coming days and weeks about "causes of autism", and most will be based on flawed, over-interpreted observational studies (1/n)

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Joni Coleman @jonicoleman.bsky.social · Jul 24

Looks like awesome work @caina89.bsky.social and team! Will have to read in more depth.

Joni Coleman @jonicoleman.bsky.social · Jul 24

ADHD label is wrong here?

Reposted by Joni Coleman

Lucina Uddin @lucinauddin.bsky.social · Jun 26

The ABCD Study 6.0 release is finally here! 🧠 Apply for data access here @theabcdstudy.bsky.social www.nbdc-datahub.org

NBDC Data Hub

NIH Brain Development Cohorts (NBDC) Data Sharing Platform: Unifying ABCD and HBCD data management in one powerful platform.

www.nbdc-datahub.org

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Joni Coleman @jonicoleman.bsky.social · Jun 27

What's going on in psychiatric genetics? The @pgcgenetics.bsky.social have now published our latest progress review in @thelancetpsych.bsky.social, highlighting discovery, and laying out a map for moving forwards!

www.thelancet.com/journals/lan...

The Psychiatric Genomics Consortium: discoveries and directions

Research by the Psychiatric Genomics Consortium (PGC) has advanced the discovery of common and rare genetic variations that contribute to the susceptibility to many psychiatric disorders and neurodeve...

www.thelancet.com

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Joni Coleman @jonicoleman.bsky.social · Jun 26

Why "causal" above? Psychiatric disorders = complex traits, so variants aren't causal (c.f. Gly380Arg–FGFR3 mutations in achondroplasia). "Causal" variants in complex traits are statistically causal (responsible for the association), not necessary nor sufficient for the development of illness.

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Joni Coleman @jonicoleman.bsky.social · Jun 26

Thanks to @medresfdn.bsky.social for funding my research in fine-mapping, which led me to work with Maria and @niamhmullins.bsky.social, who are both awesome.

I talked to @medresfdn.bsky.social about these results in more depth: www.medicalresearchfoundation.org.uk/news/uncover...

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Medical Research Foundation | Uncovering the genetics of bipolar…

www.medicalresearchfoundation.org.uk

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Joni Coleman @jonicoleman.bsky.social · Jun 26

3. A pipeline for you to do it all yourself: github.com/mkoromina/SA...

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GitHub - mkoromina/SAFFARI: Statistical And Functional Fine-mApping of GWAS Risk locI (SAFFARI)

Statistical And Functional Fine-mApping of GWAS Risk locI (SAFFARI) - mkoromina/SAFFARI

github.com

Joni Coleman @jonicoleman.bsky.social · Jun 26

Fantastic to see Maria Koromina's great work out in @natneuro.nature.com!

1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis

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www.nature.com/articles/s41...

Fine-mapping genomic loci refines bipolar disorder risk genes - Nature Neuroscience

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...

www.nature.com

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Reposted by Joni Coleman

Adrian Liston @labliston.bsky.social · Jun 17

On the day we were awarded an #ERCAdG from the @erc.europa.eu, I want to highlight this non-science paper I wrote with ‪@deefitzgerald.bsky.social‬ on research culture:

wellcomeopenresearch.org/articles/9-341

Why? Because I'm often told we need to chose between excellence and kindness

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Reposted by Joni Coleman

Gerome Breen @psychgenomics.bsky.social · Jun 17

Excited about our new preprint: 1st successful genome-wide study of >61,000 panic attack and 29,000 panic disorder cases. www.medrxiv.org/content/10.1... We find 17 associations & evidence that peripheral neurons in eye, lungs and heart are involved in panic & other psychiatric disorders 1/n

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Joni Coleman @jonicoleman.bsky.social · Jun 11

Watch this space...

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Joni Coleman @jonicoleman.bsky.social · Jun 10

Can't post this without the acknowledgement:

"We dedicate this paper to Robert Keers, a wonderful friend, colleague, mentor and scientist, whom we lost too soon. This project continued in his absence, with contributions from many colleagues who helped to complete the work that he started."

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Joni Coleman @jonicoleman.bsky.social · Jun 10

Very pleased to see this paper out in @nathumbehav.nature.com – a useful approach to understanding the role of genetics in sensitising people to their environments (and a sobering example of the sample sizes needed...!)

Fantastic work by lead Elham Assary!

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rdcu.be/eqmvJ

Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes

Nature Human Behaviour - This study uncovered genetic associations with environmental sensitivity in psychiatric and neurodevelopmental traits in an international collaboration using data from more...

rdcu.be

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Joni Coleman @jonicoleman.bsky.social · Jun 5

Thursday 19th June (14:00-16:00) with Emily Petherick, Loughborough University and Anthony Khawaja, UCL and Moorfields Eye Hospital NHS Foundation Trust

Webinar registration link events.teams.microsoft.com/event/0f859b.... 4/4

Microsoft Virtual Events Powered by Teams

events.teams.microsoft.com

Joni Coleman @jonicoleman.bsky.social · Jun 5

Monday 16th June (10:00-12:00) with Catherine John, University of Leicester and Daniel Smith, University of Edinburgh

Webinar registration link: events.teams.microsoft.com/event/da8085....

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Microsoft Virtual Events Powered by Teams

events.teams.microsoft.com

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Joni Coleman @jonicoleman.bsky.social · Jun 5

Tuesday 10th June (12.00-14.00) with Robert Maidstone, University of Manchester

Webinar registration link - events.teams.microsoft.com/event/4364bc... 2/4

Microsoft Virtual Events Powered by Teams

events.teams.microsoft.com

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Joni Coleman @jonicoleman.bsky.social · Jun 5

I'm fortunate enough to be a Research Scholar with OurFutureHealth, the UK’s largest health research programme. They are hosting webinars for researchers to share the exciting opportunities this unique resource can offer your research. 1/4

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Joni Coleman @jonicoleman.bsky.social · Jun 5

Dammit, that's so much more pithy than my 30 minute lecture saying the same thing...

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Joni Coleman @jonicoleman.bsky.social · Jun 4

"Didn’t I tell ya baby, I am J9 Austin!!"

Joni Coleman @jonicoleman.bsky.social · May 30

10000000 apologies Abi and Meg – I KNEW that list of names seemed to short.

a brown dog is sitting in a bowl with its paws on the floor and says sorry .

ALT: a brown dog is sitting in a bowl with its paws on the floor and says sorry .

media.tenor.com

Joni Coleman @jonicoleman.bsky.social · May 30

Not my expertise, but my guess is that UK Biobank have a) participants who are very research-motivated and willing to engage (remember most people invited to UK Biobank didn't do it!), and b) zealously protect their participants time such that they are only asked to do 1-2 big things per year.

Joni Coleman @jonicoleman.bsky.social · May 29

🙏🙏🙏 Code team:
@johanzvrskovec.bsky.social @helenadavies.bsky.social @markjamesadams.bsky.social @topherhuebel.bsky.social Zhaoying Yu Danyang Yi @rujiawang.bsky.social Jared Maina

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Joni Coleman @jonicoleman.bsky.social · May 29

Thanks also to the coding team (see next bleet) who put together the algorithms for this work, which can be found here: github.com/ColemanResea... (as well as a mirror on the DATAMIND GitHub)

(RAP-friendly implementation is a work in progress...!)

GitHub - ColemanResearchGroup/MHQ2: Code for deriving phenotypes from the second Mental Health Questionnaire in UK Biobank

Code for deriving phenotypes from the second Mental Health Questionnaire in UK Biobank - ColemanResearchGroup/MHQ2

github.com

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