Lightnews — Scholar-powered news

Joram Mooiweer @jorammooiweer.bsky.social · 1d

In the light of “#mTOR regulates everything,” HDAC5 just gave it access to your mucus factory.

Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus.
Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫

www.biorxiv.org/content/10.1...

Translational control of innate barrier defense by the gut microbiota

The intestinal epithelium is protected by a mucus barrier, infused with antimicrobial proteins, that restricts microbial access to host tissue. Because assembling this barrier is energetically costly,...

www.biorxiv.org

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Joram Mooiweer @jorammooiweer.bsky.social · 1d

CD74 — once thought of as a marker of antigen-presenting or regulatory cells — marks and even supports cytotoxic T cell function!

www.biorxiv.org/content/10.1...

ETV4 restrains the formation of CD74+ cytotoxic exhausted CD8+ T cells

Exhausted CD8+ T (Tex) cells comprise heterogeneous subsets with varying cytotoxic and dysfunctional properties, making inhibitory receptor profiles unreliable indicators of function. Therefore, it is...

www.biorxiv.org

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Reposted by Joram Mooiweer

Joana F Neves @nevesjf.bsky.social · 2d

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids

Decoding γδ T cell-epithelial interactions in the human intestine in health and disease - MRC DTP

The human gut epithelium performs vital absorptive functions, while simultaneously forming a physical barrier between the gut contents and the body. As such it is essential for health and its dysregul...

kcl-mrcdtp.com

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Reposted by Joram Mooiweer

meisellab.bsky.social @meisellab.bsky.social · Jul 9

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

www.cell.com

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Joram Mooiweer @jorammooiweer.bsky.social · 7d

FFS

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Reposted by Joram Mooiweer

Yuri Pritykin @yuripritykin.bsky.social · 19d

Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...

🧵 Key findings below 👇

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Reposted by Joram Mooiweer

Neil McCarthy @neilemccarthy.bsky.social · 17d

📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...

www.biorxiv.org

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Joram Mooiweer @jorammooiweer.bsky.social · 17d

Awesome work, congrats! Really happy to see this great example of the use of the gut-chip!

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Reposted by Joram Mooiweer

Joris Hageman @jorihag.bsky.social · Jul 29

I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

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Reposted by Joram Mooiweer

Swiss Young Immunologists Society @syis-ecr.bsky.social · Jul 20

👋 Hello Bluesky community! We are the Swiss Young Immunologists Society, a network of young immunologists across CH🇨🇭 to connect, support each other, and boost our visibility on national and European levels.

✨👉 Follow us and stay tuned for updates on events, opportunities, and all things immunology!

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Reposted by Joram Mooiweer

Cecilia Johansson @cjohansson-lab.bsky.social · Jul 28

Exciting data on oral tolerance induction are just out from several groups! I had the pleasure of writing a commentary www.science.org/stoken/autho... on the elegant study from @chrysothemisbrown.bsky.social.
Don’t miss it if you're interested in mucosal immunology www.science.org/doi/10.1126/...

RORing for oral tolerance

An antigen-presenting cell subtype tames the immune response to food antigens in early life

www.science.org

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Reposted by Joram Mooiweer

Biology Open @biologyopen.bsky.social · Jul 22

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO.

#FastandFairPeerReview #PeerReview #ScientificPublishing

Two scatter plots compare the time to first decision with reviews (in working days) for "Fast & Fair" and "Conventional" peer review methods. The left plot, titled "July-Dec 2024 peer reviewed only," and the right plot, titled "Jan-Jun 2025 peer reviewed only," both show that "Fast & Fair" has significantly lower decision times than "Conventional." Each plot has a Y-axis ranging from 0 to 100 working days and X-axis categories for the two review methods. Data points cluster lower for "Fast & Fair" and higher for "Conventional," with blue lines indicating lower mean times for "Fast & Fair." Asterisks (****) above both plots indicate statistical significance. A caption notes that the blue line represents the mean.

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Joram Mooiweer @jorammooiweer.bsky.social · Jul 15

Not sure if this works to trick LLMs, but this illustrates well how ineffective the peer-review enterprise is.
Hacking the system.

Joachim Goedhart @joachimgoedhart.bsky.social · Jul 15

'Positive review only': Researchers hide AI prompts in papers
asia.nikkei.com/Business/Tec...

'Positive review only': Researchers hide AI prompts in papers

Instructions in preprints from 14 universities highlight controversy on AI in peer review

asia.nikkei.com

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Joram Mooiweer @jorammooiweer.bsky.social · Jul 14

About intestinal immune tolerance:

Weaning sparks a wave of IL-10⁺, T-bet⁺ Tr1 CD4⁺ T cells in the small-intestinal. Surprise: they’re fueled by diet, not microbiota, via a cDC1→IL-27 axis, arming the gut with microbiota-independent, suppressive immunity.

www.biorxiv.org/content/10.1...

T-bet expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape

Intestinal immunity defends against enteric pathogens, mediates symbiotic relationships with the resident microbiota, and provides tolerance to food antigens, safeguarding critical nutrient absorption...

www.biorxiv.org

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Joram Mooiweer @jorammooiweer.bsky.social · Jul 14

www.biorxiv.org/content/10.1...

Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience

Plasticity is a central mechanism underlying the robust regenerative capacity of the intestinal epithelium. Two major plasticity have been described: spatial plasticity, in which differentiated cells ...

www.biorxiv.org

Joram Mooiweer @jorammooiweer.bsky.social · Jul 14

Every cell is a stem cell!

Even ‘terminal’ enterocytes can hit reset: Gut damage triggers a YAP/TAZ-driven fetal program → stress-proof “revival” stem cells → Lgr5⁺ CBC stem cells, rebuilding crypts from scratch and make organoids.
#StemCellPlasticity #Organoids #Gut

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Joram Mooiweer @jorammooiweer.bsky.social · Jul 8

Or LLMs crawling through editor-curated reports…?

Joram Mooiweer @jorammooiweer.bsky.social · Jul 8

Agreed!

But even if we would solve that research assessment problem, discriminating ‘good research’ from ‘bad research’ in bulk (e.g. when screening CV’s) will still need a metric that allows for ‘quick screening’

I.e., a context-rich metric that reflects the merits of the research.
What metric?

Zen Faulkes @doctorzen.net · Jul 8

Many problems in scholarly publishing are research assessment problems in disguise.

DORA @dorassessment.bsky.social · Jul 8

Innovations in #ScholarlyCommunication and #ResponsibleResearchAssessment need to go hand in hand. New guest post by @jasonchin.bsky.social, @ludowaltman.bsky.social, and Kathryn Zeiler, editors at @metaror.bsky.social, share insights on these connections. Read more👇
sfdora.org/2025/07/08/m...

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Reposted by Joram Mooiweer

Marija Matejčić @marija-matejcic.bsky.social · Jul 4

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

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Joram Mooiweer @jorammooiweer.bsky.social · Jul 6

A ‘simple’ experiment but an amazing gem of a reference!

Just stimulate blood, observe and describe…

#ImmunoSky

Adam Braithwaite @braithwaiteat.bsky.social · Jul 3

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

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Reposted by Joram Mooiweer

PF Anderson @pfanderson.bsky.social · Jul 4

This is WILD! “Cumulative evidence suggests a … previously unknown intergenerational inheritance mechanisms that propagate through the gut–germline–placenta axis in males, thru which the father’s gut microbiome influences offspring health & disease susceptibility.” www.science.org/doi/10.1126/...