The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

De Jonghe et al. present a comprehensive review of current commercial single-cell and spatial omic technologies, outlining key platforms, methodologies, and trends shaping the field—from microfluidics and plate-based approaches to combinatorial indexing, highlighting their applications in drug discovery. The authors discuss emerging engineering and computational advancements that are enabling more efficient data generation and interpretation. Finally, they explore new tools and techniques that promise to expand the scope of omic analyses, driving innovation and understanding in biomedical research.