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Joshua Frenster

@joshifrenster.bsky.social

200 followers 260 following 19 posts

Cell competition in development/gastruloids (postdoc Alfonso Martinez Arias lab) Previously: adhesion GPCRs in Glioblastoma (PhD Placantonakis Lab NYU)

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Joshua Frenster @joshifrenster.bsky.social · Nov 20

Let's get the discussion rolling with a starter pack that will grow over time!
go.bsky.app/JyvbmXA

#gastruloid #stembryo #gastruloids

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Reposted by Joshua Frenster

Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 14d

We are excited to announce the first Western VGZT of Season 7! 🎉

🗓️ Thursday, October 2nd
⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET

Our speakers:

👉 Antonia Weberling (@a-weberling.bsky.social)

👉 Sanjay Narayanaswamy (@sanjay-n.bsky.social)

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Reposted by Joshua Frenster

Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · Jul 8

Join the VGZT Eastern KEYNOTE lecture ☀️☕ TOMORROW

🗓️ Wednesday July 09
⏰ 13:30 IST / 17:00 JST / 8:00 UTC / 10:00 CET

Featuring:
1) Maithreyi Narasimha
👉Positioning tissues during Drosophila morphogenesis

Jose Silva @josesilvalab.bsky.social
👉From founder cells to organogenesis-stage embryo model

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Reposted by Joshua Frenster

Dr. Peter Walentek (Walentek Lab) @walenteklab.bsky.social · Jun 16

Save the date 📅! Our TriNational #devbio #stemcell Meeting 2025 will be held in Freiburg on Sept. 19th. As always, participation is free and talks will be selected from early career scientists. Joun us 😊
Info: devstemcell.org/home

@biozentrum.unibas.ch @uni-freiburg.de @igbmc.bsky.social

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Joshua Frenster @joshifrenster.bsky.social · Jun 4

Big news! "researchers will be eligible to apply for a Starting Grant immediately after successfully defending their PhD, and at any time within the following ten-year period." #ERC #ERCstarting
erc.europa.eu/news-events/...

Changes to the 2026 and 2027 Work Programmes

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

erc.europa.eu

Reposted by Joshua Frenster

Gonca Erdemci-Tandogan @goncaerdemci.bsky.social · May 9

I'm excited to join @pritiagarwal.bsky.social and @tarafinegan.bsky.social as a co-organizer for the International Developmental Mechanics Seminar Series. The series will resume in September 2025, and call for speakers is now open! More info is on our new website: sites.google.com/view/devmech...

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Reposted by Joshua Frenster

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Apr 16

📢 Fresh off the press and featuring new exciting experiments! 🧪
We show how glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling - happy to finally share this 😊
doi.org/10.1016/j.st...

B2B with @jesseveenvliet.bsky.social lab: doi.org/10.1016/j.st... 🤩

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Joshua Frenster @joshifrenster.bsky.social · Mar 23

I'm really grateful for the large turnout of our Gastruloid meeting in Barcelona. Close to 100 researchers from 9 countries. With the gastruloid field expanding, I hope that the community stays this close and that the meeting becomes an annual tradition! #gastruloids #conference

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Reposted by Joshua Frenster

Alfonso Martinez Arias @amartinezarias.bsky.social · Mar 21

The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.

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Reposted by Joshua Frenster

Kristina Stapornwongkul @kstapornwongkul.bsky.social · Mar 20

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

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Joshua Frenster @joshifrenster.bsky.social · Mar 20

Today's session was brilliantly opened up by David Turner @gastruloids.bsky.social giving a historical overview of where gastruloids came from, where we stand now, and what we as a community need to keep an eye on!

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Joshua Frenster @joshifrenster.bsky.social · Mar 20

First day of our Gastruloid Meeting in Barcelona kicking off with amazing talks and discussion and a room filled with gastruloid enthusiasts! #gastruloids #conference

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Reposted by Joshua Frenster

gastrulomicslab.bsky.social @gastrulomicslab.bsky.social · Mar 13

Excited to share our latest paper in DevCell! We show how EOMES and the SWI/SNF complex collaborate to drive chromatin remodeling, establishing mesoderm and endoderm differentiation potential.

Read the full paper here: www.cell.com/developmenta...

EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME...

www.cell.com

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Reposted by Joshua Frenster

Acebrón @acebronsp.bsky.social · Feb 26

Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response

The EMBO Journal @embojournal.org · Feb 21

SIRF: Sergio Acebron @acebronsp.bsky.social @cosheidelberg.bsky.social and colleagues develop a new #biosensor reporting on functional interactions between dsDNA sensor STING and #IRF3, allowing to capture STING activation upon various triggers
www.embopress.org/doi/full/10....

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Joshua Frenster @joshifrenster.bsky.social · Jan 30

Thinking about the Spanish word "anoche", I realized that we forgot the English word "yestereve". Bring back concise words!

Reposted by Joshua Frenster

Alfonso Martinez Arias @amartinezarias.bsky.social · Jan 26

1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵

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Reposted by Joshua Frenster

André Dias @dias-andre.bsky.social · Jan 13

www.biorxiv.org/content/10.1...

Here we explore the role of #Wnt and #Nodal signalling during mammalian gastrulation using #gastruloids. Building on the work of many labs, we propose that antagonistic signalling-dependent #modularity in the PS establishes the early mammalian body plan.

A temporal coordination between Nodal and Wnt signalling governs the emergence of the mammalian body plan

Nodal and Wnt signalling play an important role in the emergence of the mammalian body plan, primarily by orchestrating gastrulation and primitive streak formation. While the literature suggests that ...

www.biorxiv.org

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Joshua Frenster @joshifrenster.bsky.social · Dec 23

You're on it now!

Joshua Frenster @joshifrenster.bsky.social · Dec 23

Already on it :)

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Reposted by Joshua Frenster

Alfonso Martinez Arias @amartinezarias.bsky.social · Dec 17

We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis
#IInNumbersWeTrust #NotInTheGenes

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Reposted by Joshua Frenster

Levayer Lab @levayerr.bsky.social · Dec 8

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...

Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur

research.pasteur.fr

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Joshua Frenster @joshifrenster.bsky.social · Dec 4

When late science-nights reward you with those types of views, it makes it all worth it!

Joshua Frenster @joshifrenster.bsky.social · Dec 4

Is this what competition for nutrients looks like? I see no competition for space...

Joshua Frenster @joshifrenster.bsky.social · Dec 2

Perfect :)

Joshua Frenster @joshifrenster.bsky.social · Dec 1

A motivational "neural tube + somites sando" :)

Joshua Frenster @joshifrenster.bsky.social · Nov 30

Got it :)