Lightnews — Scholar-powered news

Luca Jovine @jovinelab.org · Sep 5

Beautiful work as always Max - congratulations!!!

Luca Jovine @jovinelab.org · Aug 14

Great to get another peek at this story, after hosting @jacob-hanna.bsky.social as keynote speaker of our recent #GRC on Fertilization and Activation of Development!

Human Frontier Science Program @hfspo.bsky.social · Aug 14

🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages.
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.

Full lecture 🎥 👉 zurl.co/Tgf4f
#sts

HFSP Nakasone Award 2025 Lecture – Jacob Hanna on Synthetic Embryo Models

In this official HFSP Nakasone Award lecture, Professor Jacob (Yaqub) Hanna of the Weizmann Institute of Science shares the groundbreaking research that earn...

www.youtube.com

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Luca Jovine @jovinelab.org · Jul 29

Lovely to have you here, and great talk!

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Luca Jovine @jovinelab.org · Jul 22

Huge thanks to my partners in crime — Rafael Fissore, @virginiasavy.bsky.social and Shweta Bhagwat — it’s been a real pleasure to shape this program with you over the course of the past two years.

Very much looking forward to reconnecting with old colleagues and meeting new ones!

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Luca Jovine @jovinelab.org · Jul 22

It will be an honor to co-chair this #GRC, which has long been my favorite meeting and brings together a fantastic community of researchers working on gamete biology and early development.

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Luca Jovine @jovinelab.org · Jul 22

Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away!

www.grc.org/fertilizatio...

www.grc.org/fertilizatio...

#GRC #GRS #fertilization #development #egg #sperm

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Luca Jovine @jovinelab.org · Jul 13

👍🎾🇮🇹

The New York Times @nytimes.com · Jul 13

Breaking News from @theathletic.bsky.social: Jannik Sinner defeated Carlos Alcaraz in a 4-set duel to win his first Wimbledon title.

Wimbledon final: Jannik Sinner beats Carlos Alcaraz to win first Wimbledon title

Five weeks after their French Open classic, Sinner outplayed Alcaraz from the baseline to win his first Wimbledon title.

www.nytimes.com

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Reposted by Luca Jovine

Sergey Ovchinnikov @sokrypton.org · Jul 12

Molecular cat tweezers? 😺

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Luca Jovine @jovinelab.org · Jul 11

Beautiful work as always Kelly!

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Luca Jovine @jovinelab.org · May 20

Congrats also here!

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Luca Jovine @jovinelab.org · May 19

Yes a real homozygous deletion apparently!

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Luca Jovine @jovinelab.org · May 19

Will tell mine and see whether she confirms 😺

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Reposted by Luca Jovine

Meera Sundaram @meera-sundaram.bsky.social · May 17

Up on biorxiv! The tour de force protein tagging atlas for the #Celegans cuticle #aECM - from Jordan Ward @gotworms.bsky.social and Andrew Chisholm labs. So many beautiful images of cuticle collagen substructures !! www.biorxiv.org/content/10.1...

Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging

Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in viv...

www.biorxiv.org

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Luca Jovine @jovinelab.org · May 11

Thanks @svtnyheter.bsky.social for covering our #ZP2 non-hormonal #contraception story!

www.svt.se/nyheter/inri...

@ki.se
@esrf.fr
@pnas.org
@vetenskapsradet.bsky.social
@kawresearch.bsky.social

Ny forskning kan leda till hormonfritt preventivmedel

Jakten på ett hormonfritt preventivmedel har pågått i många år. Nu har forskare på KI upptäckt ett sätt att stoppa befruktning med hjälp av antikroppar. – Det hade gett kvinnor möjligheten att själva ...

www.svt.se

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Luca Jovine @jovinelab.org · Apr 30

As an old tRNA aficionado, can't help loving this beautiful tour-de-force cryo-EM work on one of nature's coolest molecules! Congrats @sebastianglatt.bsky.social and colleagues!!!

Sebastian Glatt @sebastianglatt.bsky.social · Apr 30

We are very excited about our latest work, which just came out @embojournal.org – www.embopress.org/doi/full/10..... The work @MCB_UJ was driven by Anna Biela and Ting-Yu Lin 林亭妤 in collaboration with @jmbujnicki.bsky.social…a short🧵

Determining the effects of pseudouridine incorporation on human tRNAs | The EMBO Journal

imageimagetRNAs harbour a complex set of modifications which are important for their function. Here, single particle cryo-EM, biophysics, and computational analyses of the effects of pseudouridine inc...

www.embopress.org

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Luca Jovine @jovinelab.org · Apr 23

Changed handle to @jovinelab.org !

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Luca Jovine @jovinelab.org · Apr 23

www.forskning.se/2025/04/17/i...

Preventivmedel utan hormoner – med hjälp av antikroppar - forskning.se

Med hjälp av antikroppar kan man blockera befruktning på äggets yta. Nu har forskare tagit ett steg närmare ett hormonfritt preventivmedel.

www.forskning.se

Luca Jovine @jovinelab.org · Apr 14

Thank you Neha! 😊

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Luca Jovine @jovinelab.org · Apr 14

Thanks Björn!

Luca Jovine @jovinelab.org · Apr 14

Thanks again @esrf.fr !

www.esrf.fr/sites/www/ho...

Non-hormonal contraception visualised with X-rays

www.esrf.fr

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Luca Jovine @jovinelab.org · Apr 14

New step taken towards non-hormonal contraception

news.ki.se/new-step-tak...

New step taken towards non-hormonal contraception

A new study from Karolinska Institutet shows how a small antibody fragment can block fertilisation by targeting a key protein on the surface of the egg. This discovery brings a non-hormonal contracept...

news.ki.se

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Luca Jovine @jovinelab.org · Apr 14

Together with the first structural information on a monoclonal antibody bound to a key female #fertilization protein, this paves the way to the development of targeted non-hormonal #contraceptives

#StructuralBiology #ReproductiveBiology #AntibodyEngineering #NonHormonalContraception

Luca Jovine @jovinelab.org · Apr 14

Here we show that a ScFV fragment of IE-3 is sufficient to block #fertilization in vitro, avoiding potential Fc-associated side effects

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Luca Jovine @jovinelab.org · Apr 14

Fresh off the press in @pnas.org: functional and structural studies of the interaction between #fertilization-blocking mAb IE-3 and mammalian #egg coat protein #ZP2

www.pnas.org/doi/10.1073/...

Thanks to
@vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de

Structural basis of ZP2-targeted female nonhormonal contraception | PNAS

Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an...

www.pnas.org

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Luca Jovine @jovinelab.org · Mar 22

Indeed! 😆

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