Proteins that bind to a target protein of interest, termed "binders," are essential components of biological research reagents and therapeutics. Target proteins present multiple binding surfaces with ...

The wide availability, ease of manipulation, and access to spatiotemporal control make light an attractive stimulus for controlling dynamic covalent chemistries/networks. In this work, a series of pho...

Harnessing Atomic-Level Precision and Computational Intelligence to Build Materials of the Future

Near-infrared (NIR, 700–1700 nm)- and telecom (∼1260–1625 nm)-emissive molecules are good candidates for biological imaging and quantum sensing applications, respectively; however, bright low energy e...

Molecule and semiconductor combination could open new avenues for technology, discovery

When the cationic, octahedral terminal nitrido complex of Mo(VI) supported by a diborate pentadentate ligand is generated in the absence of trapping nucleophiles, it activates the C(sp2)–H bonds of si...

YouTube video by ABC 7 Chicago

FUBP1 is identified as an Nm-binding protein that regulates Nm-dependent splicing via intronic sites on chromatin-associated RNA.

The discovery of materials with programmable combinations of charge transport and magnetic properties is a major goal in synthetic chemistry. Molecular materials, such as coordination polymers (CPs), are emerging candidates in this field due to their synthetic modularity. While there are many conductive or magnetic CPs, single-component examples with both properties are still emerging. Here we demonstrate how alloying paramagnetic Fe(III) centers into a highly conductive Ni-based CP results in novel amorphous materials with high conductivity and giant magnetoresistance. Aliovalent doping with paramagnetic Fe centers engenders spin-glass transitions, while Ni and the strong π-stacking interactions of tetrathiafulvalene-2,3,6,7-tetrathiolate (TTFtt) ligands support conductivity. Ni0.69Fe0.31TTFtt has σ ≈ 200 S/cm and a 1.8 K magnetoresistance of −52% at 5 T, among the largest for any coordination solid. This work demonstrates not only how magnetic properties can be rationally incorporated into conductive CPs, but also an unexpected potential for amorphous materials in spintronic applications.

1,2-oxaborines can shift into 11 different ring shapes to make modifying molecular cores easy

Annual event draws 700 UChicago scientists, 200 volunteers to share science demonstrations on campus

Polyfluoroarenes often exist in functional molecules; however, construction of alkyl–polyfluoroaryl bonds remains nontrivial, and the current approaches exhibit various limitations. Here we report the...

Susumu Kitagawa, Richard Robson and Omar Yaghi take top prize for discovery and development of versatile materials with a huge surface area