Kai S. Shimagaki
kai-shimagaki.bsky.social
Kai S. Shimagaki
@kai-shimagaki.bsky.social
Exploring efficient computation, statistical inference, evolution, genetics & immunology 💻🧬📈. Postdoc, John Barton Lab @ Pitt Comp & Sys Bio. PhD, Martin Weigt Lab @ Sorbonne Univ (UPMC).
Reposted by Kai S. Shimagaki
The constant barrage of terrible news on bluesky has made me feel weird about promoting papers, but people in the lab have been doing so much amazing work over the past few months that I want to share a few brief teasers/links:
September 10, 2025 at 4:46 PM
Reposted by Kai S. Shimagaki
🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
Reposted by Kai S. Shimagaki
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
Reposted by Kai S. Shimagaki
Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point.

matsen.group/general/2025...
Replaying evolution to learn about the fitness landscape of affinity maturation
A five year collaboration with the Victora lab is bearing fruit for evolutionary biology.
matsen.group
December 11, 2025 at 5:36 PM
Reposted by Kai S. Shimagaki
In #GENETICS, @kai-shimagaki.bsky.social and @jpbarton.bsky.social present a novel computational method for inferring epistasis that substantially reduces computational costs without affecting accuracy, and successfully validated this approach on longitudinal HIV-1 evolution data.
buff.ly/6pYhfee
August 22, 2025 at 1:04 PM
Reposted by Kai S. Shimagaki
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social

looking to hire 2 postdocs to join us in this endeavor.

more details can be found here: sites.google.com/uw.edu/statp...
SPE - join us
Postdoctoral position: In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI). We are looking for talented postd...
sites.google.com
October 27, 2025 at 8:47 PM
Reposted by Kai S. Shimagaki
The Mahan postdoctoral fellowship offers 21 months of support to develop your own research with Fred Hutch computational biology faculty-- lots of excellent labs to choose from!
Apply: apply.interfolio.com/172697
Faculty: www.fredhutch.org/en/research...
Herbold Computational Biology Faculty & Labs
www.fredhutch.org
October 19, 2025 at 5:40 PM
Reposted by Kai S. Shimagaki
Applications for the 2026 Stengl-Wyer Scholars Program are open! The program provides up to 3 years of support for talented postdoctoral researchers in the broad area of the diversity of life and/or organisms in their natural environments. Learn more here: utexas.infoready4.com/CompetitionS...
August 5, 2025 at 9:09 PM
Reposted by Kai S. Shimagaki
I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share!
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
September 2, 2025 at 5:24 PM
Reposted by Kai S. Shimagaki
New OpEd by @michaelmina.bsky.social on #HHS vaccine policy changes driven by ideology rather than evidence that will increase infectious disease threats.

www.nytimes.com/2025/06/11/o...
Opinion | It’s Code Red for Vaccines in America (Gift Article)
How to make sense of all the vaccine policy changes.
www.nytimes.com
June 11, 2025 at 12:52 PM
Reposted by Kai S. Shimagaki
My first post here brings lovely news: just heard that all of my NIH and NSF grants were officially terminated today. Have been expecting this for some time, but still jarring to see the news.

Have heard similar news from dozens of colleagues. Will be hard, but we'll find a way forward.
May 15, 2025 at 11:06 PM
Reposted by Kai S. Shimagaki
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
May 13, 2025 at 11:37 PM
Reposted by Kai S. Shimagaki
I’m excited to share some new work, out now in Nature Communications. We used genomic surveillance data 🧬 to identify mutations that could make SARS-CoV-2 more transmissible.

rdcu.be/d8cS7
Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data
Nature Communications - Identifying mutations in pathogen genomes that confer transmission advantages could improve understanding of viral biology and flag variants for further study. Here, the...
rdcu.be
January 31, 2025 at 10:00 PM
Reposted by Kai S. Shimagaki
Hey there! A short intro 🧵: My lab studies evolution (esp. viral pathogens) and the immune system. We often use ideas from statistical physics, which was the focus of my PhD. Here are a few recent highlights to give an idea of the kinds of problems we like to work on. 👇
December 1, 2024 at 9:21 PM