Kari Hoffman
karihoffman.bsky.social
Kari Hoffman
@karihoffman.bsky.social
neuroscientist @vanderbilt studying neural circuit+population rules for creating and deploying knowledge. computational neuroethology.
For all 3, IMO cross-task, cross-region, cross-species will offer insights. The sparse sampling across these is a hindrance (Blake’s point was directed at the task component). We’re working on it…
December 13, 2025 at 6:23 PM
Reposted by Kari Hoffman
let's talk in person!
but fwiw I personally think that we talk about dimensionality! to me the important ideas within the neural manifold framework are: (1) manifolds reflect biological constraints, (2) capture population-wide functions/computations, (3) manifolds (may) have ontological power
December 13, 2025 at 5:49 PM
Ooh! that’s relevant work for us, thanks for reposting. (Shamelessness is underrated!)
December 12, 2025 at 4:13 PM
Stacked lineup, anything to be streamed or recorded?
December 12, 2025 at 3:51 PM
Also affects public (state) universities most, which are generally more affordable. If there is emigration, students with greater $ need may be disproportionately affected. Again.
December 12, 2025 at 2:51 PM
Reposted by Kari Hoffman
We give examples for less striking number of neurons here. For different species, tasks, and brain areas, it's always the same observation: PCA overestimates the dimensionality -except for one very simple task- and this overestimate gets worse w the number of neurons

www.biorxiv.org/content/10.1...
Nonlinear manifolds underlie neural population activity during behaviour
There is rich variety in the activity of single neurons recorded during behaviour. Yet, these diverse single neuron responses can be well described by relatively few patterns of neural co-modulation. ...
www.biorxiv.org
December 12, 2025 at 12:51 AM
Jan. 8-11, more info here: parkcitywinterconf.org
Park City Winter Conference – Park City Winter Conference on the Neurobiology of Learning and Memory
parkcitywinterconf.org
December 11, 2025 at 5:25 PM
#1 The Discussions! Best explained by founding member Jim McGaugh.

OK, what did I miss?
parkcitywinterconf.org/register/

6/6
December 11, 2025 at 5:07 PM
#2 Latest, sometimes controversial, findings. Hear unpublished results, hot takes that speakers haven’t yet disclosed to the big crowds. Every year, I hear it here first. During the meeting or after, at the Hotel Bar. 👇

5/6
December 11, 2025 at 5:07 PM
#3 BDNF your brain. 🤯Curated sessions from a wide array of specializations, in a small format. The topics that are the least familiar are often the ones I end up enjoying the most at this meeting. Such as, why “BDNF your brain” is a bit of an eye roll, but still beats a dopamine cleanse. 👇

4/6
December 11, 2025 at 5:07 PM
#4 Introvert-friendly networking. Yeah, that’s a thing. Single track sessions, ample down time for meaningful conversations, or to recharge. Mentorship luncheon for ECRs. Do the Data Blitz at the start, for an introduction. Ice broken. (Disclosure: also works for extroverts)👇

3/6
a man in a black shirt is saying this socializing thing is brutal
Alt: a man in a black shirt is saying this socializing thing is brutal
media.tenor.com
December 11, 2025 at 5:07 PM
#5 Activities – and not just skiing. Snowshoeing, hiking, fat tire biking, bougie spas, excursions to the main drag, High West Distillery. Touch gra- well, snow. 👇

2/6
December 11, 2025 at 5:07 PM