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Shubhangini Kataruka

@kataruka.bsky.social

43 followers 49 following 3 posts

Postdoc @ Lesch lab, Yale University. Former @ svobodalab.bsky.social Embryo, chromatin, epigenetics and reproduction.

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Reposted by Shubhangini Kataruka

Bluma Lesch @ambystoma22.bsky.social · Aug 20

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

H3K4me3 amplifies transcription at intergenic active regulatory elements

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Shubhangini Kataruka @kataruka.bsky.social · Aug 1

Truly a team effort from the Lesch lab @ambystoma22.bsky.social Happy to share this paper where we study the role of Smarca5 in spermatogenesis.
www.pnas.org/doi/10.1073/...

SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals | PNAS

Establishment of correct chromatin configuration in male meiosis is essential for sperm formation and male fertility. However, how chromatin remode...

www.pnas.org

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Shubhangini Kataruka @kataruka.bsky.social · May 28

Thanks Pratyush ☺️

Shubhangini Kataruka @kataruka.bsky.social · May 27

So excited to be part of this exceptional group of scientists!

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · May 27

We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.

Learn more about these exceptional scientists:

www.leadingedgesymposium.org/fellows

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