banner
kenjilee.bsky.social
Kenji Lee
@kenjilee.bsky.social
810 followers 710 following 57 posts
Ph.D. student studying the in vivo identification of cell types and the neural dynamics of decision making in prefrontal cortex. Chand Lab @ BU; NINDS F31 Fellow; prev. UW, Allen Inst., and U. Puget Sound. From Hawaii 🌴
Posts Media Videos Starter Packs
Pinned
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Aug 1
Are you allowed another tweeprint for a revised preprint? Anyways, it's been a year since we first put out PhysMAP (I also do [many] monkey experiments!) and thanks to some excellent reviews + additional co-authors, we're really excited about where we've landed! www.biorxiv.org/content/10.1...
A multimodal approach for visualization and identification of electrophysiological cell types in vivo
Neurons of different types perform diverse computations and coordinate their activity during sensation, perception, and action. While electrophysiological recordings can measure the activity of many n...
www.biorxiv.org
2 2 12
Reposted by Kenji Lee
scienceyael.bsky.social
Ya'el Courtney, PhD @scienceyael.bsky.social · 7d
🚨 Psychedelics in pregnancy - can a single dose reach the embryo and matter? Yes. In mice they hit embryonic CSF within minutes, activate choroid plexus→CSF axis, & shift cortical development with adult behavioral signatures. @lehtinenlab.bsky.social Preprint:

www.biorxiv.org/content/10.1...

1/13
Gestational psychedelic exposure disrupts brain development and offspring behavior in mice
Despite increasing non-medical use and clinical investigation of psychedelics, the consequences of prenatal exposure remain unknown. In mice, maternal lysergic acid diethylamide (LSD; 0.3 mg/kg) cross...
www.biorxiv.org
2 14 49
Reposted by Kenji Lee
jonathanamichaels.bsky.social
Jonathan A. Michaels @jonathanamichaels.bsky.social · 7d
The neural control & computation lab is recruiting!

If you're interested in using large-scale neural population recordings to study how the brain learns to produce complex and flexible behaviours, please get in touch.

www.ncclab.ca
5 43 95
Reposted by Kenji Lee
sgrella.bsky.social
Stephanie L. Grella, PhD @sgrella.bsky.social · 2d
First lab paper out today! Student authors: Mikayla Cutler and Abhi Thati 🎉🤩

Hippocampus | Neuroscience Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors
Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction-related ph....
onlinelibrary.wiley.com
3 18 33
Reposted by Kenji Lee
sfn.org
Society for Neuroscience @sfn.org · 6d
What does it take to build a thriving lab?

In latest episode of “Think Alike?”, Yosif (Joe) Zaki, PhD, and Zach Pennington, PhD, join mentor Denise Cai, PhD, to share honest reflections on trust, mentorship, and the power of open communication.

🎧Listen now: vist.ly/4939f
2 6
Reposted by Kenji Lee
safa-science.bsky.social
Science and Freedom Alliance - SAFA @safa-science.bsky.social · 7d
Federal workers are speaking out on how the Trump regime is harming Americans:

"We stand here today at a moment of the greatest assault of our lifetimes on our freedoms. The US Constitution is being shredded... We are here to call on Congress to stand up and stop it."

youtu.be/uw1KwIBgrCw?...
Mark Histed, NIH Scientist *speaking in personal capacity
YouTube video by Civil Servants Coalition
youtu.be
6 170 340
Reposted by Kenji Lee
teissa.bsky.social
teissa.bsky.social @teissa.bsky.social · 11d
Come join our exciting new computational neuroscience groups! Fantastic people, cool mountains, and exciting science!
laurelinelogiaco.bsky.social
Laureline Logiaco @laurelinelogiaco.bsky.social · 11d
Interested in doing a Ph.D. to work on building models of the brain/behavior? Consider applying to graduate schools at CU Anschutz:
1. Neuroscience www.cuanschutz.edu/graduate-pro...
2. Bioengineering engineering.ucdenver.edu/bioengineeri...

You could work with several comp neuro PIs, including me.
3 6
Reposted by Kenji Lee
nature.com
Nature @nature.com · 15d
Nature research paper: Repeated head trauma causes neuron loss and inflammation in young athletes

go.nature.com/46oZgeT
Repeated head trauma causes neuron loss and inflammation in young athletes - Nature
Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.
go.nature.com
6 33
Reposted by Kenji Lee
rdgao.bsky.social
Richard Gao @rdgao.bsky.social · 15d
I've been waiting some years to make this joke and now it’s real:

I conned somebody into giving me a faculty job!

I’m starting as a W1 Tenure-Track Professor at Goethe University Frankfurt in a week (lol), in the Faculty of CS and Math

and I'm recruiting PhD students 🤗
a man wearing a white shirt and tie smiles in front of a window
ALT: a man wearing a white shirt and tie smiles in front of a window
media.tenor.com
30 31 180
Reposted by Kenji Lee
apeyrache.bsky.social
Adrien Peyrache @apeyrache.bsky.social · 20d
So happy to see Morgane Butler, a former and brilliant undergrad student in the lab, publishing her PhD work. Looks super interesting.

www.nature.com/articles/s41...
Repeated head trauma causes neuron loss and inflammation in young athletes - Nature
Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.
www.nature.com
1 9
Reposted by Kenji Lee
mictott.bsky.social
Michael Totty @mictott.bsky.social · 21d
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
www.science.org
3 15 35
Reposted by Kenji Lee
thomas-zhihao-luo.bsky.social
Thomas Luo @thomas-zhihao-luo.bsky.social · 21d
How does the brain decide? 🧠

Our new @nature.com paper shows that neural activity switches from an 'evidence gathering' to a 'commitment' state at a precise moment we call nTc.

After nTc, new evidence is ignored, revealing a neural marker for the instant when the mind is made up.

rdcu.be/eGUrv
Transitions in dynamical regime and neural mode during perceptual decisions - Nature
Simultaneous recordings were made of hundreds of neurons in the rat frontal cortex and striatum, showing that decision commitment involves a rapid, coordinated transition in dynamical regime and neura...
www.nature.com
14 96 250
Reposted by Kenji Lee
chase-mackey.bsky.social
Chase Mackey @chase-mackey.bsky.social · 21d
New work from Yoshi Kajikawa and myself! 🐒 🦻

We measured sound envelope encoding in different cortical layers across the nonhuman primate auditory cortical hierarchy for the first time. Thread below.
1 1 1
Reposted by Kenji Lee
cosynemeeting.bsky.social
cosynemeeting.bsky.social @cosynemeeting.bsky.social · 29d
#Cosyne2026 is now open for business!

Show us what you got both for the main meeting & workshop proposals 🧠🥳🧠🥳🧠
21 43
Reposted by Kenji Lee
mchurchland.bsky.social
mchurchland.bsky.social @mchurchland.bsky.social · Sep 8
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric.
www.biorxiv.org/content/10.1...
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
www.biorxiv.org
3 24 70
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 5
Oh for sure! Didn't mean to discount that, I just don't want people thinking every decision making variable is everywhere because of this one!
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 4
I think upcoming action choice is privileged. Seems to be everywhere even in primates except for the earliest sensory areas. Almost like the entire brain receives an efference copy of the action. Of course, when action is the only variable in your task, everything looks everywhere.
1 2
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 4
Arguably, the mice are undertrained relative to most any primate experiment. Some of our monkeys have been doing the same task longer than several mouse lifetimes!
1 1
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 4
It's hard to argue everything is everywhere once you unconfound your task variables more carefully (posting your fig for others)! Unfortunately, I haven't seen many that do so in mice because presumably it is difficult to train. I think Shin's work is one www.nature.com/articles/s41... of the few
1
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 4
I think your triple dissociation paper is one of those other works that I would point to. Same with others from the value-based decision making literature like www.pnas.org/doi/10.1073/... where value is strongly but transiently encoded in OFC but evidence for action choice accumulates only in DLPFC
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
1
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Sep 4
It is highly dependent on the task complexity I would argue. There are certain task variables we see that are highly localized but the complexity of mouse experiments do not elicit them. Here is an example www.nature.com/articles/s41... We've just finished recordings and are writing them up now.
Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus–response associations are known - Nature Communications
It is not clear to what degree activity in dorsal premotor cortex (PMd) reflects perceptual-deliberation versus action-selection aspects of decision-making. Here, the authors report that monkey PMd ne...
www.nature.com
1 4
Reposted by Kenji Lee
neurograce.bsky.social
Grace Lindsay @neurograce.bsky.social · Aug 24
ATTN🚨: I will be looking for PhD students through NYU's Center for Data Science PhD program this year. Applicants should have an interest in either NeuroAI (specifically biological attention or AI interpretability) or ML for Remote Sensing. Visit my lab website for more info: lindsay-lab.github.io
PhD in Data Science: Admissions Requirements | NYU CDS
Discover the PhD in Data Science requirements at NYU. Learn about deadlines, required degrees, coursework, and application details for Fall 2025 admissions.
cds.nyu.edu
44 66
Reposted by Kenji Lee
victoryofflight.bsky.social
Dionnet L Bhatti Mazo @victoryofflight.bsky.social · Jun 16
Our new preprint: 𝐅𝐞𝐚𝐭𝐮𝐫𝐞-𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜 𝐭𝐡𝐫𝐞𝐚𝐭 𝐜𝐨𝐝𝐢𝐧𝐠 𝐢𝐧 𝐥𝐚𝐭𝐞𝐫𝐚𝐥 𝐬𝐞𝐩𝐭𝐮𝐦 𝐠𝐮𝐢𝐝𝐞𝐬 𝐝𝐞𝐟𝐞𝐧𝐬𝐢𝐯𝐞 𝐚𝐜𝐭𝐢𝐨𝐧.

We describe how the LS guides defensive responses by forming critical computations built from functionally and molecularly distinct cells and their afferent inputs.

www.researchsquare.com/article/rs-6...
Feature-specific threat coding in lateral septum guides defensive action
The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral septum...
www.researchsquare.com
4 10 22
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Aug 1
Addendum: it feels wrong to self-promote in this moment when there are so many other issues more deserving of your attention but I appreciate you reading this. I'm so grateful to be able to continue to do science. I'll be at SfN! (I'm also supposedly looking for a postdoc, if those still exist).
2
Reposted by Kenji Lee
juangallego.bsky.social
Juan Gallego @juangallego.bsky.social · Aug 1
🚨New paper🚨

Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently.

Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
2 46 160
kenjilee.bsky.social
Kenji Lee @kenjilee.bsky.social · Aug 1
And of course, big thanks to Chand as well for help with every part of the process! Happy to answer any questions and hopefully the code will be cleaned up soon so you can try it out on your own data! (unfortunately, I am once again neck deep in monkey ephys 🙈)
1 2