KLAB - finding a cure for GI dysmotility at #HarvardStrong
@klab.bsky.social
3K followers 1.5K following 910 posts
Neurobiology Lab studying development, maintenance, and aging of the Enteric Nervous System. Home of 'enfant terrible' of enteric neurobiology https://www.enteric-neuron.com
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klab.bsky.social
It only took about 8 years or so for our initial discovery of continual adult enteric neurogenesis to be shown to be clinically relevant in a major GI disorder
klab.bsky.social
What an amazing study that shows how 3 different subsets of achalasia patients' suffer from a loss of ENS structure -associated with subset-specific changes to their ENS neurogenic programs!

The case for continual #neurogenesis in adult #ENS, and its #clinical significance keeps building up
Differential Neurogenesis Status Among Achalasia Subtypes
The varying neurogenesis status across achalasia subtypes was suggested by the different counts of enteric neural progenitor cells (ENPCs), immature, and mature nitrergic axon innervation in the lowe...
onlinelibrary.wiley.com
klab.bsky.social
#Nobel prize is awarded for how to stop a defence system from turning on its own

Scale it up and see it's relevance to current affairs, scale it down to see it's relevance to medicine and physiology
klab.bsky.social
It is often easier for folks from global south to come to US, Canada and Europe during summer precisely because the schools have holidays. It is often difficult and sometimes impossible for them to leave day to day responsibility of family during a school year and travel to the other side of the 🌎
klab.bsky.social
An important case report on underlying changes to ENS structure in Ehlers Danlos Disease patients that suffer from GI dysfunction

journals.lww.com/acgcr/fullte...
journals.lww.com
klab.bsky.social
Masterful takedown by @jeremymberg.bsky.social of an unserious article

@nytimes.com article is based more on vibes than fact & as is norm these days - pretends to be deep

If @nytimes.com was serious, they would invite @jeremymberg.bsky.social to write a counterpoint
jeremymberg.bsky.social
Now with comments... Lots of comments

(A long thread)

1/n
klab.bsky.social
It's amazing that the @nytimes.com can keep coming up with half assed pieces with this regularity
klab.bsky.social
Family obligations do not exist in other parts of the world in months other than August when conferences get scheduled?
klab.bsky.social
Going viral on social media is the new journal impact factor

Credit @tomgauld.bsky.social
Reposted by KLAB - finding a cure for GI dysmotility at #HarvardStrong
senguptalab.bsky.social
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!
klab.bsky.social
Dieter Ebert used to organize workshops for graduate students in a remote village called Guarda in Swiss highlands.
No phones, no internet, just informal talks on theoretical science.
Walk out at night and see the milky way with little light pollution
BLISS
klab.bsky.social
Rooting for you Michael, glad you got atleast part of the funding released