labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo)
@labinoue.bsky.social
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Jun 20
Our new study by Takashi, Yuma, and Masae on color-tuning mechanism of bestrhodopsin was published in JPC Lett.!🙌✨By introducing its residues into GR, we revealed the role of the counterion triad and key residues for red-shifted absorption and unique isomerization😊
pubs.acs.org/doi/10.1021/...
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · 4d
A new article on retinal chemistry in rhodopsins by Prof. Mizutani in Nat. Chem.!🎉
www.nature.com/articles/s41...
Harnessing light the retinal way - Nature Chemistry
Yasuhisa Mizutani marvels at how effectively nature utilizes the π-conjugated system of retinal in proteins.
www.nature.com
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · 4d
A new heliorhodopsin (V2HeR) from a giant virus by the Prof. Kandori lab🧬 Congratulations!🎉
www.jstage.jst.go.jp/article/biop...
@bejalab.bsky.social
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · 5d
21st International Conference on Retinal Proteins (ICRP2026) will be held in Siena, Italy, from September 14 to 19, 2026
Chair- Massimo Olivucci,
Co-Chair- Kwang-Hwang Jung
www.congressi.unisi.it/retinalprote...
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
emekato.bsky.social
Hideaki E. Kato @emekato.bsky.social · 20d
Happy to share our new preprint on the red-shifted channelrhodopsin ChR024, recently discovered by Inoue Lab (biorxiv.org/content/10.1...
), highlighting its long-wavelength absorption and ion conductance:
biorxiv.org/content/10.1...

Many thanks to our wonderful lab members and collaborators!
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · 20d
Structural basis for color tuning and passive ion conductance in red-shifted pump-fold channelrhodopsin ChR024 www.biorxiv.org/content/10.1...
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · 21d
A preprint on a newly discovered long-wavelength-absorbing rhodopsin channel has been released. This molecule was identified based on machine-learning predictions that we have been developing with Prof. Ichiro Takeuchi’s group at Nagoya University🧬
www.biorxiv.org/content/10.1...
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
oyiz.bsky.social
Ofer Yizhar @oyiz.bsky.social · 25d
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
natmicrobiol.nature.com
Nature Microbiology @natmicrobiol.nature.com · Sep 8
#NewResearch

Carotenoids enhance rhodopsin function as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism enhancing light energy capture and expanding microbial phototrophy.

#MicroSky

@labinoue.bsky.social @susumu31.bsky.social

www.nature.com/articles/s41...
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota - Nature Microbiology
In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands ...
www.nature.com
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
susumu31.bsky.social
Susumu Yoshizawa @susumu31.bsky.social · Sep 4
Our paper reporting a new light-harvesting system in H⁺ & Cl⁻-pumping rhodopsins of marine bacteria is now out in Nature Microbiology! So excited!!!
Key discoveries (using isolated cultures from the research cruise Mirai MR10-01 — personally, this is super exciting🔥):
www.nature.com/articles/s41...
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota - Nature Microbiology
In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands ...
www.nature.com
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Sep 4
In this study, we collaborated with Prof. Yoshizawa, Prof. Shirouzu, and their teams. Inoue examined the energy transfer efficiency from carotenoids to retinal using transient absorption spectroscopy. In these H+ and Cl- pumps, carotenoids not only act as antennas, they accelerate the photocycle✨
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Sep 4
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota www.nature.com/articles/s41... @susumu31.bsky.social @labinoue.bsky.social
Carotenoids bind rhodopsins and act as photocycle-accelerating pigments in marine Bacteroidota - Nature Microbiology
In marine bacteria, carotenoids enhance rhodopsin function by acting as light-harvesting antennae and photocycle-accelerating pigments, a dual mechanism that enhances light energy capture and expands ...
www.nature.com
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Aug 23
Adaptive loss of shortwave-sensitive opsins (SWS) during cartilaginous fish evolution🦈SWS cause cell death, and in cartilaginous fishes, where the impact is particularly pronounced, they evolutionarily lost these genes to avoid such effects🧬
www.nature.com/articles/s41...
@natcomms.nature.com
Adaptive loss of shortwave-sensitive opsins during cartilaginous fish evolution - Nature Communications
Cartilaginous fishes lost the short-wave-sensitive (sws) opsin genes at some point in their evolutionary history. Here, the authors present genome assemblies of Okamejei kenojei (skate) and Prionace g...
www.nature.com
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Aug 19
Scramblase activity of actionorhodopsin🧐
www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
Opsins are Phospholipid Scramblases in All Domains of Life
Opsins are highly abundant retinal proteins in the membranes of photoheterotrophic bacteria. However, some microbial genomes encode an opsin but lack the gene for the final enzyme in retinal synthesis...
www.biorxiv.org
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Aug 11
Time-resolved FTIR study of anion channelrhodopsin, GtACR1. The O intermediate can contribute to channel opening upon photoexcitation🔦🌟
www.nature.com/articles/s42...
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Jul 31
Mitochondrial optogenetics using delta-rhodopsin the discovery of a new elements of the origin of sleep pressure😳
www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 30
we got the cover!! www.biophys.jp/biophysics_a...
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Jul 30
Two papers from our lab were featured as cover art—Takashi’s bestrhodopsin mimicking GR for the Supplementary Cover of JPC Lett., and Takahashi-kun’s HulaChrimson for the Cover Picture of BPPB! ✨🥳
pubs.acs.org/toc/jpclcd/1...
www.biophys.jp/biophysics_a...
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 29
Origin of the Red-Shifted Absorption Maximum in Channelrhodopsin Chrimson pubs.rsc.org/en/content/a...
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 20
v2 in bioRxiv!! Oceanic cyanobacterial photosynthesis is negatively affected by viral NblA proteins www.biorxiv.org/content/10.1...
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bluetools-project.eu
Bluetools Project @bluetools-project.eu · Jul 17
🧪🦠New study by Bluetools partners at Technion and collaborators shows how marine archaea use HeimdallRs to harvest a broader range of sunlight. Published in Nature Microbiology:  https://www.bluetools-project.eu/how-marine-archaea-use-light-a-closer-look-at-heimdallrs/
#MarineMicrobes #Rhodopsins
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 15
Multistep 11-cis to All-trans Retinal Photoisomerization in Bestrhodopsin, an Unusual Microbial Rhodopsin pubs.acs.org/doi/full/10....
Multistep 11-cis to All-trans Retinal Photoisomerization in Bestrhodopsin, an Unusual Microbial Rhodopsin
Rhodopsins constitute a broad class of retinal-binding photoreceptors. Microbial rhodopsins are canonically activated through an all-trans to 13-cis photoisomerization, whereas animal rhodopsins are m...
pubs.acs.org
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 15
Survival strategies of planktonic organisms in alpine lakes and beyond www.tandfonline.com/doi/full/10....
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jul 6
CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments www.science.org/doi/10.1126/...
CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments
Spectroscopy, structural, and functional study of microbial rhodopsins with characteristic long-living near–UV-absorbing state.
www.science.org
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Jul 4
Congratulations to Hiroto on his first “first-author” paper. HulaChrimson was found through metatranscriptome analysis from Lake Hula by the Oded group!🎉🥳 Thank you for the fantastic collaboration!🙌
@bejalab.bsky.social @shaifain.bsky.social‬
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labinoue.bsky.social
INOUE lab. (ISSP, Univ. Tokyo) @labinoue.bsky.social · Jul 4
A new paper led by Hiroto (M2 student) on the novel channelrhodopsin HulaChrimson is now out in BPPB!✨ Interestingly, despite high similarity to red-absorbing Chrimson and sharing key residues, HulaChrimson shows blue absorption🫐🧐 www.jstage.jst.go.jp/article/biop...
#OpenAccess
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Reposted by INOUE lab. (ISSP, Univ. Tokyo)
bejalab.bsky.social
BejaLab @bejalab.bsky.social · Jun 26
Selective Choice of the Efficient Carotenoid Antenna by a Xanthorhodopsin: Controlling Factors for Binding and Excitation Energy Transfer pubs.acs.org/doi/10.1021/...
Selective Choice of the Efficient Carotenoid Antenna by a Xanthorhodopsin: Controlling Factors for Binding and Excitation Energy Transfer
Despite extensive research on carotenoids and microbial rhodopsins in aquatic environments, a fundamental understanding of the binding requirements of carotenoids that serve as auxiliary light-harvest...
pubs.acs.org
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