IMAGE Lab
@labphan.bsky.social
B cells | Macrophages | Immunity | Autoimmunity | Cancer | Osteoclasts | Osteomorphs | Intravital imaging | Precision Immunology
...the Macro category left me feeling attacked...😅
January 6, 2026 at 10:08 AM
...the Macro category left me feeling attacked...😅
Yes but play it backwards.
January 5, 2026 at 9:46 PM
Yes but play it backwards.
Congrats Kelly and everyone involved! Lovely work really enjoyed reading it.
January 3, 2026 at 4:31 AM
Congrats Kelly and everyone involved! Lovely work really enjoyed reading it.
Yea but how big was the photon? 😅
October 9, 2025 at 7:36 AM
Yea but how big was the photon? 😅
Nice one congrats John et al!
July 31, 2025 at 8:22 AM
Nice one congrats John et al!
Much obliged will do. 😊
June 26, 2025 at 9:58 PM
Much obliged will do. 😊
But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3
June 26, 2025 at 11:38 AM
But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3
Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3
Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type
Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression…
www.sciencedirect.com
June 26, 2025 at 11:38 AM
Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3