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@labphan.bsky.social

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IMAGE Lab @labphan.bsky.social · Apr 29

Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵

Macrophages direct location-dependent recall of B cell memory to vaccination

Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

www.sciencedirect.com

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IMAGE Lab @labphan.bsky.social · 1d

Yea but how big was the photon? 😅

Reposted by IMAGE Lab

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

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IMAGE Lab @labphan.bsky.social · Jul 31

Nice one congrats John et al!

IMAGE Lab @labphan.bsky.social · Jul 30

Out @nature.com led by @jdegregori.bsky.social Mercedes Rincon @roelvermeulen.bsky.social @jaguirreghisolab.bsky.social et al. in vivo mouse models & human data show resp. infections drive IL-6 dependent re-awakening of dormant cancer cells in lung.

So much to like about this paper! Congrats all!

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

www.nature.com

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IMAGE Lab @labphan.bsky.social · Jul 10

Very excited at the chance to work with new people with new ideas in immunology! Really keen to hear from people from diverse backgrounds with different ways of thinking. International applicants seeking freedom to pursue BlueSky projects welcome. Come for the science. Stay for the vibe!
#immunosky

Lab Big Day Out June 2025! On ferry to Manly on a cold winter's day!

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Reposted by IMAGE Lab

Elizabeth McKenna @elizsmckenna.bsky.social · Jun 24

Now online in Cancer Discovery: AAnet Resolves a Continuum of Spatially-Localized Cell States to Unveil Intratumoral Heterogeneity - by Aarthi Venkat, Scott Youlten, Beatriz San Juan, Smita Krishnaswamy, Christine Chaffer, and colleagues doi.org/10.1158/2159...

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IMAGE Lab @labphan.bsky.social · Jun 26

Much obliged will do. 😊

IMAGE Lab @labphan.bsky.social · Jun 26

😅

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IMAGE Lab @labphan.bsky.social · Jun 26

Yes please!

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IMAGE Lab @labphan.bsky.social · Jun 26

But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3

IMAGE Lab @labphan.bsky.social · Jun 26

Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3

Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type

Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression…

www.sciencedirect.com

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IMAGE Lab @labphan.bsky.social · Jun 26

Christine Chaffer, @skummerf.bsky.social at @garvaninstitute.bsky.social, Smita Krishnaswamy at Yale et al present AAnet a neural network for nonlinear archetype analysis that more accurately captures cell plasticity & learns the spatial organisation of the archetypes. What is the advance? 1/3

AAnet resolves a continuum of spatially-localized cell states to unveil intratumoral heterogeneity

Abstract. Identifying functionally important cell states and structure within heterogeneous tumors remains a significant biological and computational challenge. Current clustering or trajectory-based ...

aacrjournals.org

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Reposted by IMAGE Lab

Joe Sabatino @jsabatino37.bsky.social · Jun 6

Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment

onlinelibrary.wiley.com/doi/10.1002/...

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, gui....

onlinelibrary.wiley.com

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Reposted by IMAGE Lab

Kamila Marzec @drkamilamarzec.bsky.social · May 30

It was wonderful to meet with the #OCCAMS Consortium today on #WorldMSDay for an update on our study progress, as well as reviewing recent literature on the role of EBV in multiple sclerosis. Thanks to all participants for joining in the great discussions!
@garvaninstitute.bsky.social

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IMAGE Lab @labphan.bsky.social · May 13

What have the National Institutes of Health ever done for us?

What Have The Romans... - Monty Python's Life of Brian

YouTube video by Monty Python

www.youtube.com

IMAGE Lab @labphan.bsky.social · May 5

Thanks Kamila!

IMAGE Lab @labphan.bsky.social · May 3

Not sure if this is what you meant. DOCK8 deficiency (but not STAT3) is reported to have peripheral blood ILC3 defect which corrects after HSCT. In contrast, SCID patients may not reconstitute their NKs and ILCs after HSCT with no obvious health consequences suggesting they are dispensable.

Evidence of innate lymphoid cell redundancy in humans - Nature Immunology

The importance of human innate lymphoid cells to normal human physiology is unclear. Vivier and colleagues find that immunodeficient patients ‘rescued’ with normal bone marrow can recover their T cell...

www.nature.com

Reposted by IMAGE Lab

Cheri Sirois @cherisirois.bsky.social · May 2

Though every Cell paper is special, I occasionally get a paper that ✨delights✨ me from start to finish. These astute scientists found a unique opportunity to study an audacious snake venom enthusiast and uncovered antibodies that could serve as a broad antidote to snakebites. 🐍

Cell - a Cell Press journal @cp-cell.bsky.social · May 2

Now online! Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies

Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies

To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a combination of two of the identified antibodies with an inhibitory drug can protect mice from envenomation by medically important snakes found around the world.

dlvr.it

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IMAGE Lab @labphan.bsky.social · Apr 30

Thanks Mauro! They make beautiful memories!

Reposted by IMAGE Lab

Waggoner Lab @labwaggoner.bsky.social · Apr 29

Macrophages direct location-dependent recall of B cell memory to vaccination @cellcellpress.bsky.social @ramadhenni.bsky.social @immunodealex.bsky.social
www.cell.com/cell/fulltex...

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IMAGE Lab @labphan.bsky.social · Apr 29

Thanks Cheri!

IMAGE Lab @labphan.bsky.social · Apr 29

Thanks Jen!

Reposted by IMAGE Lab

Marcus Robinson @robinsonmj.bsky.social · Apr 29

Vaccination in left arm, right arm, or both?? @labphan.bsky.social congrats and looking to you for the answer 😄

Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...

Macrophages direct location-dependent recall of B cell memory to vaccination

Subcapsular sinus macrophages in the draining lymph node help retain resident memory B cells in the subcapsular niche and promote their re-entry into secondary germinal centers. Boosting vaccines in t...

www.cell.com

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IMAGE Lab @labphan.bsky.social · Apr 29

So location does matter & boosting on the same side may make a difference! Basic research can underpin clinical translation. Can't have one without the other! Thankful to all our funders especially NHMRC, ACRF & UNSW Scientia Program. Thank you for reading please check out our paper! End 🧵

Macrophages direct location-dependent recall of B cell memory to vaccination

Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…

www.sciencedirect.com

IMAGE Lab @labphan.bsky.social · Apr 29

This was associated with more rapid secretion of neutralising antibodies against the ancestral strain in the vaccine as well as Delta and Omicron variants. In agreement, there was more somatic hypermutation & antibody diversification in the boosted dLN compared to ndLN.

Serum neutralising antibody levels against ancestral, Delta and Omicron variants.

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