Karim Majzoub
@karimaj.bsky.social
Group leader @igmm-montpel.bsky.social studying viruses - ERC Stg- Amateur athlete and musician- Husband and father- Europtimist @biolum-montpellier.bsky.social
https://www.igmm.cnrs.fr/en/team/rna-viruses-and-host-factors/
https://www.igmm.cnrs.fr/en/team/rna-viruses-and-host-factors/
Pinned
Karim Majzoub
@karimaj.bsky.social
· Oct 9
Great crowd and attendance for our France-Japan Virology workshop we kicked off this morning !
STING and PiPs !
PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Phosphatidylinositol 3,5-bisphosphate is a ligand of STING and, together with cGAMP, induces STING activation and innate immune responses.
www.nature.com
February 5, 2026 at 7:27 PM
STING and PiPs !
Reposted by Karim Majzoub
All you want for christmas is.... transposon mutagenesis!
Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team.
Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)
Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team.
Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)
December 24, 2025 at 3:03 PM
All you want for christmas is.... transposon mutagenesis!
Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team.
Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)
Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team.
Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)
Reposted by Karim Majzoub
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Endogenous retroviruses, RNA and human development !
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...
www.science.org
January 24, 2026 at 11:55 PM
Endogenous retroviruses, RNA and human development !
Zoe Denis a PhD student in our lab , describing the first marsupial deltavirus ! :)
A replication-competent deltavirus from the marsupial fat-tailed dunnart Sminthopsis crassicaudata
Deltaviruses are circular, negative-sense RNA agents that replicate autonomously but depend on heterologous envelope glycoproteins for spread. Only partial sequences of deltaviruses had been reported ...
www.microbiologyresearch.org
January 16, 2026 at 7:07 PM
Zoe Denis a PhD student in our lab , describing the first marsupial deltavirus ! :)
TimeVaults record cellular transcriptomes
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 16, 2026 at 7:11 AM
TimeVaults record cellular transcriptomes
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple
sclerosis, with T cell responses against ANO2 occurring in over half of patients.
These ANO2-specific T cells shar...
www.cell.com
January 14, 2026 at 10:58 PM
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Kudos @jbdsf.bsky.social and team for this beautiful work !
Bacteriophage genome-wide transposon mutagenesis
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...
www.biorxiv.org
January 14, 2026 at 9:54 PM
Kudos @jbdsf.bsky.social and team for this beautiful work !
Very interesting interview
What’s Wrong with NIH Grants?
“Science is fundamentally different than remodeling a kitchen”
www.statecraft.pub
January 13, 2026 at 6:21 PM
Very interesting interview
pTOS is the new glp1?
Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway
Most mammals consume small and frequent meals. By contrast, pythons are ambush predators that exhibit extreme feeding and fasting patterns and provide a unique model for uncovering molecular mediators...
www.biorxiv.org
January 13, 2026 at 5:37 AM
pTOS is the new glp1?
Reposted by Karim Majzoub
January 2, 2026 at 9:04 PM
Reposted by Karim Majzoub
Hmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;)
www.quantamagazine.org/how-dads-fit...
www.quantamagazine.org/how-dads-fit...
How Dad’s Fitness May Be Packaged and Passed Down in Sperm RNA | Quanta Magazine
Research into how a father’s choices — such as diet, exercise, stress, nicotine use — may transfer traits to his children has become impossible to ignore.
www.quantamagazine.org
December 22, 2025 at 5:59 PM
Hmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;)
www.quantamagazine.org/how-dads-fit...
www.quantamagazine.org/how-dads-fit...
Reposted by Karim Majzoub
“The math is brutal and the juxtaposition stark: millions for OpenAI while pink slips go out to longtime lecturers. The CSU isn’t investing in education—it’s outsourcing it, paying premium prices for a chatbot many students were already using for free.“
www.currentaffairs.org/news/ai-is-d...
www.currentaffairs.org/news/ai-is-d...
AI is Destroying the University and Learning Itself
Students use AI to write papers, professors use AI to grade them, degrees become meaningless, and tech companies make fortunes. Welcome to the death of higher education.
www.currentaffairs.org
December 3, 2025 at 2:58 AM
“The math is brutal and the juxtaposition stark: millions for OpenAI while pink slips go out to longtime lecturers. The CSU isn’t investing in education—it’s outsourcing it, paying premium prices for a chatbot many students were already using for free.“
www.currentaffairs.org/news/ai-is-d...
www.currentaffairs.org/news/ai-is-d...
Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
How does fever work?
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.
This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵
www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 8:11 PM
Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and a hyperthermic nouse model 🦠 www.science.org/doi/10.1126/...
#flu
#flu
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 8:09 PM
Really neat and elegant Virology by @samjwilsonphd.bsky.social and team ! Watch out for these avian PB1 pol subunits ! Congrats to all co-authors ! @science.org
Reposted by Karim Majzoub
🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
November 27, 2025 at 9:35 AM
🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
November 14, 2025 at 2:27 PM
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
Bravo @mkrupovic.bsky.social and team !
November 13, 2025 at 11:04 AM
Bravo @mkrupovic.bsky.social and team !
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
www.nature.com
October 29, 2025 at 8:06 PM
P-bodies , microRNAs and cell fate ! Not everything is transcription in cell fate decisions ;)
Reposted by Karim Majzoub
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Karim Majzoub
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !
Acidosis orchestrates adaptations of energy metabolism in tumors
Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...
www.science.org
October 20, 2025 at 7:07 PM
Shout out for @johanneszuber.bsky.social and team ! Beautiful work with new biology !
Reposted by Karim Majzoub
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Karim Majzoub
@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍.
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
Boa Constrictor Brain Cells Slither into Focus
From reptiles and Tasmanian devils to humans, one researcher zooms in on unseen features of the brain and liver cells, like the cytoskeleton.
www.the-scientist.com
October 13, 2025 at 11:13 AM
@viroscope.bsky.social (@karimaj.bsky.social team) partage dans The Scientist ses travaux sur les deltavirus et l’imagerie de cellules, des cellules humaines aux cellules de boa constrictor 🐍.
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...
👉 Lire l’article : “Boa Constrictor Brain Cells Slither into Focus”
www.the-scientist.com/boa-constric...