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Reposted by Alex Crits-Christoph

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 9h

My HPLC was definitely overlooked

www.nature.com/articles/d41...

Prizes must recognize machine contributions to discovery

The future of science will be written by humans and machines together. Awards should reflect that reality.

www.nature.com

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Reposted by Alex Crits-Christoph

Craig MacLean @craigmaclean.bsky.social · 19h

New pre-print www.biorxiv.org/content/10.1...
Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social!
#phagesky#microsky

Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage

Phage therapy is a promising alternative to antibiotics to treat multidrug resistant infections. Plasmid dependent phages (PDPs) are particularly attractive as therapeutics because they can both kill ...

www.biorxiv.org

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Reposted by Alex Crits-Christoph

Keith Smith @drkeithsmith.bsky.social · 11h

How can we tell what's inside an #exoplanet? @timlichtenberg.bsky.social et al review how a planet's atmosphere interacts with its interior. Atmospheric observations can distinguish between lava worlds, water worlds, temperate surfaces or supercritical interiors. ☄️
www.science.org/doi/10.1126/...

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Reposted by Alex Crits-Christoph

gostin.bsky.social @gostin.bsky.social · 10h

RFK has mounted a full assault on @CDCgov-- slashing funding & staff, & and turned the agency into a political tool that can no longer be fully trusted on public health recommendations, especially vaccines.

Out today in JAMA Health Forum

Peter Lurie CSPI

jamanetwork.com/journals/jam...

Assault on the Centers for Disease Control and Prevention—Budget Cuts, Political Control, and the Erosion of Trust

This JAMA Forum discusses measures the Trump administration has taken against the US Centers for Disease Control and Prevention that include budget cuts and program eliminations, workforce reductions ...

jamanetwork.com

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Reposted by Alex Crits-Christoph

Ákos T Kovács @evolvedbiofilm.bsky.social · 22h

Glad to share a collaboration with Yicen Lin's group at Kunming University of Science and Technology published in ISME Journal

Synergistic biodegradation of polyethylene by experimentally evolved bacterial biofilms
academic.oup.com/ismej/advanc...

#MicrobiomeEcology at #LeidenBiology

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Carl Zimmer @carlzimmer.com · 1d

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

nyti.ms

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Alex Crits-Christoph @acritschristoph.bsky.social · 1d

and the nice thing about climate change is, every bit counts! Unless we're playing "Oh but will talking about ERW distract people from the obviously most important thing which is getting rid of fossil fuels" game, which is kinda true but also kind of paternalistic IMO

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Alex Crits-Christoph @acritschristoph.bsky.social · 1d

some links
drawdown.org/explorer/dep...
www.nature.com/articles/s41...
www.nature.com/articles/s43...
www.pnas.org/doi/10.1073/...

Other questions like how ephemeral are carbon stocks in soils? are v important and being studied! But, these approaches likely play real *partial* roles in co2 drawdown

Deploy Enhanced Rock Weathering

Enhanced rock weathering removes CO₂ from the air by accelerating the natural chemical and physical breakdown of certain rocks. This carbon removal practice can be effective and has been deployed in p...

drawdown.org

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Alex Crits-Christoph @acritschristoph.bsky.social · 1d

Yes it almost certainly does, and this is more so true as societies and industries electrify

I think folks shouldn't talk past each other and just say: "ERW is good and can likely help with climate change but not come close to solving it, which still requires rapid transition from fossil fuels"

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Reposted by Alex Crits-Christoph

labnikel.bsky.social @labnikel.bsky.social · 1d

🚀 Thrilled to share our new Nature Communications article:
“A blueprint for designing the next-generation of synthetic C1 microbes”
We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts.
🔗 www.nature.com/articles/s41... A short 🧵1/4

A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications

Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

www.nature.com

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Alex Crits-Christoph @acritschristoph.bsky.social · 1d

I really like how you aggregate comments across sites. Is that done automatically? How the heck do you accomplish that?

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Reposted by Alex Crits-Christoph

Moritz Kraemer @mugkraemer.bsky.social · 1d

The role of climate variability in shaping the 2023/24 outbreak of Dengue in Brazil (📉 in north regions; 📈 in southern populous regions).

Brazil recorded the largest outbreak on record which coincided with the warmest ever reported temperatures in the Americas.

www.medrxiv.org/content/10.1...

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Rosa Lafer-Sousa @rosalafersousa.bsky.social · 2d

Over the weekend ICE abducted an NIH contractor when he showed up to a courthouse for his green card hearing. He is documented. His wife is a citizen.

He is also member of the skeleton crew of animal care staff that works through a shutdown, to ensure the health and wellbeing of research animals.

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Alan McNally @alanmcn1.bsky.social · 2d

After being with the journal since its very inception, the time has come for me to step back from Microbial Genomics. This is a wonderful opportunity to have a leadership role in one of the leading journals for microbial genomics research

microbiologysociety.org/news/society...

<i>Microbial Genomics </i> Deputy Editor-in-Chief: Call for Expressions of interest

microbiologysociety.org

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Alex Crits-Christoph @acritschristoph.bsky.social · 2d

Really interesting to hear your bindcraft challenges. "BindCraft appears to be much better at targeting certain binding pockets than others" common wisdom right now, but hope we can start to generalize it....

Dumb q: any evidence many of your 100+ binders *are* binding, just not inhibiting >LOD?

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Eric Topol @erictopol.bsky.social · 2d

www.washingtonpost.com/opinions/202...

Opinion | Six surgeons general: It’s our duty to warn the nation about RFK Jr.

We took an oath to declare dangers when we found them. We’re doing that again today.

www.washingtonpost.com

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Maddy Seale @maddyseale.bsky.social · 2d

Wonderful to see this beautiful image on the cover of Science this week highlighting a paper that uses high resolution imaging to show the spatial patterns of bacterial attraction to glutamine from roots.
Paper here: www.science.org/doi/10.1126/...
Perspective here: www.science.org/doi/10.1126/...

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Matthew Hahn @3rdreviewer.bsky.social · 3d

The most important paper in evolutionary biology I'd never heard of:

1/

www.sciencedirect.com/science/arti...

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Jeremy Berg @jeremymberg.bsky.social · 3d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Reposted by Alex Crits-Christoph

Michael Brockhurst @brockhurstlab.bsky.social · 3d

New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

www.biorxiv.org

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Alex Crits-Christoph @acritschristoph.bsky.social · 3d

The full language is even worse, asking to ban gene drives and microbes as well. Would exclude work like this on modified mosquitoes: www.npr.org/2024/01/26/1...

I love the IUCN, but also, they have no political authority, this is just a suggestion. Not a good one though!

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Alex Crits-Christoph @acritschristoph.bsky.social · 3d

I don't think there's any great answer here but running all of the HMMs with HMMsearch and then doing the stats separately

maybe github.com/WrightonLabC..., although I haven't used it recently myself ...

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Climate Cabinet Action @climatecabinet.org · 6d

Since Trump took office the U.S. has been backsliding on climate. New data shows we’re now falling far behind on cutting pollution to protect people’s health and our future.

But this isn’t inevitable. State and local leaders have real power to step up, act boldly, and keep climate progress alive.

Chart: Trump is slowing climate progress. Here’s how much.

After Trump’s budget law and regulatory rollbacks, the country’s carbon emissions are set to fall much slower than they would have under the Biden admin.

www.canarymedia.com

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Reposted by Alex Crits-Christoph

Edward Nirenberg @enirenberg.bsky.social · 3d

This year's Nobel Prize in Physiology or Medicine was just announced:
www.nobelprize.org/prizes/medic...

This seems like a good opportunity for me to explain a bit about peripheral immune tolerance and where the prizewinners' work comes in 🧵

6 October 2025

The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:

Mary E. Brunkow
Institute for Systems Biology,
Seattle, USA

Fred Ramsdell
Sonoma Biotherapeutics,
San Francisco, USA

Shimon Sakaguchi
Osaka University,
Osaka, Japan

“for their discoveries concerning peripheral immune tolerance”

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Reposted by Alex Crits-Christoph

The Daum Lab @daumlab.bsky.social · 3d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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