Lightnews — Scholar-powered news

Denis LJ Lafontaine @lafontainelab.bsky.social · 28d

Amazing Talk at the Ribosome meeting in Cambridge 🤩

1 3

Reposted by Denis LJ Lafontaine

Kurianlab @kurianlab.bsky.social · Aug 7

www.nature.com/articles/s41...

A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

www.nature.com

5 9

Reposted by Denis LJ Lafontaine

Gordon Simpson @ggsimpsonrna.bsky.social · Feb 24

New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...

Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis

Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

www.biorxiv.org

1 5 9

Reposted by Denis LJ Lafontaine

kelliedean99.bsky.social @kelliedean99.bsky.social · Jul 17

Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!

www.tandfonline.com/journals/krn...

TRANSLACORE, a European network to coordinate research on translation regulation in cancer

Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.

www.tandfonline.com

1 2

Denis LJ Lafontaine @lafontainelab.bsky.social · Jul 2

A Fantastic collaboration with amazing scientists 🤩☀️

1

Denis LJ Lafontaine @lafontainelab.bsky.social · Jul 2

Spending quality time with good friends at the #Helicase conference in beautiful Lisbon #RNA

3

Reposted by Denis LJ Lafontaine

Torben Heick Jensen @heick.bsky.social · Jun 27

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

6 12

Reposted by Denis LJ Lafontaine

Jordan Meier @doc-jlmeier.bsky.social · Mar 20

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

Transfer RNA acetylation regulates in vivo mammalian stress signaling

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

www.science.org

8 27 100

Reposted by Denis LJ Lafontaine

jortegamcgill.bsky.social @jortegamcgill.bsky.social · Mar 18

Message to my 11 followers in Bluesky:

We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!

Details and registration: www.eventsforce.net/hg3/frontend...

The Organizing Committee

11 16

Reposted by Denis LJ Lafontaine

Anders H. Lund @andershlund.bsky.social · Mar 19

come join!

jortegamcgill.bsky.social @jortegamcgill.bsky.social · Mar 18

Message to my 11 followers in Bluesky:

We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!

Details and registration: www.eventsforce.net/hg3/frontend...

The Organizing Committee

6 8

Reposted by Denis LJ Lafontaine

Gregor Diensthuber @gdiensthuber.bsky.social · Jan 20

How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...

2 13 38

Denis LJ Lafontaine @lafontainelab.bsky.social · Dec 23

Awesome. Can you post the link to the PDF. Thank you and 🎄

1

Denis LJ Lafontaine @lafontainelab.bsky.social · Dec 18

The ´Belgium’s Treetop Adventure: Cycling Through Trees’ 🌳 I strongly recommend 😉 Happy Holidays 🎄

Denis LJ Lafontaine @lafontainelab.bsky.social · Dec 11

Thank you for highlighting an Amazing collaboration with Eva Novoa @evamarianovoa.bsky.social

2

Reposted by Denis LJ Lafontaine

Science TLDR @sciencetldr.bsky.social · Dec 10

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

Ribosome Fingerprints: A Breakthrough in Early Cancer Detection

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

www.science-tldr.com

1 7 11

Denis LJ Lafontaine @lafontainelab.bsky.social · Dec 8

Absolutely, would be delighted

Denis LJ Lafontaine @lafontainelab.bsky.social · Dec 8

Sounds exciting ! Wonder if processing is also affected,…

1 1

Reposted by Denis LJ Lafontaine

Institute of Molecular Biology (IMB) @imbmainz.bsky.social · Nov 28

And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬

More details via www.imb.de/jobs
Application deadline is 5 January 2025

#sciencejobs #resilience #biostatistics

1 24 24

Reposted by Denis LJ Lafontaine

Anita Corbett @acorbe2.bsky.social · Nov 19

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025

1 46 84

Reposted by Denis LJ Lafontaine

Karla Neugebauer @karlaneugebauer.bsky.social · Nov 27

Published online today @jcellbiol.bsky.social you will find our latest work on Cajal bodies. 😅🎉 It has been a joy to work with Chuyue Zhang, Dahyana Arias Escayola, and colleagues! doi.org/10.1083/jcb....
#RNAsky #RNAbiology

Identification of coilin interactors reveals coordinated control of Cajal body number and structure

This study identifies new Cajal body components and tests their roles in the formation of these nuclear membraneless organelles. Imbalances in the levels o

doi.org

13 34

Reposted by Denis LJ Lafontaine

Karla Neugebauer @karlaneugebauer.bsky.social · Nov 27

We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis

An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...

www.biorxiv.org

4 28 70

Denis LJ Lafontaine @lafontainelab.bsky.social · Nov 27

Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics

15 20

Reposted by Denis LJ Lafontaine

Korostelev Lab @korostelevlab.bsky.social · Nov 24

Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9

5 12

Denis LJ Lafontaine @lafontainelab.bsky.social · Nov 25

Excellent! Could you add me to this Translation pack. Many thanks 🤩

1 3

Denis LJ Lafontaine @lafontainelab.bsky.social · Nov 25

Awesome 🤩 Can you add me to the pack. Many thanks

1 2