Laura Vella
@laura-a-vella.bsky.social
Pediatric Infectious Diseases Physician, Immunologist, One Who Is Easily Amused.
Vellalab.org
Vellalab.org
Reposted by Laura Vella
@biorxivpreprint.bsky.social Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 16, 2025 at 4:36 AM
@biorxivpreprint.bsky.social Selective infection and loss of PRDM1+ LN Tfh cells in uncontrolled HIV infection precludes formation of Tfh reservoirs under ART
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Laura Vella
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
December 16, 2025 at 4:30 AM
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
Reposted by Laura Vella
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1
December 13, 2025 at 10:16 PM
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans https://www.biorxiv.org/content/10.64898/2025.12.10.693235v1
Incredibly happy to share Sam’s work between my lab and that of @derek-oldridge.bsky.social. What cellular programs are engaged by GC-positioned human Tfh? The answers held a few surprises.
T follicular helper cells adopt alter egos and localize to diverse niches - what gene expression programs distinguish Tfh in the germinal center? After dissociating tissue samples into single-cell suspension, can we infer which Tfh were positioned in GCs? Check out our new preprint! bit.ly/3XVsrCI
Multimodal analysis defines GNG4 as a distinguishing feature of germinal center-positioned CD4 T follicular helper cells in humans
CD4 T follicular helper (Tfh) cells coordinate humoral immune responses within germinal centers (GC) of lymphoid tissue. Despite their critical roles in vaccination and autoimmunity, the gene expressi...
bit.ly
December 15, 2025 at 9:19 PM
Incredibly happy to share Sam’s work between my lab and that of @derek-oldridge.bsky.social. What cellular programs are engaged by GC-positioned human Tfh? The answers held a few surprises.