Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Abstract. Age and sex have been found to be important determinants of the mutation rate per generation in mammals, but the mechanisms underlying these fact

Phylogenetic variation, recombination rate evolution, and comparative genome structure and organization have typically been explored in isolation. The chromosomal and genomic context of selected genetic markers in phylogenetic studies is usually unknown, given the fragmented nature of most genome assemblies. It is now established that the position of markers in the genome can strongly influence the inferred phylogeny, often not reflecting speciation patterns and subsequent bifurcating tree structure but rather post-speciation introgression. The recent availability of chromosome-level genome assemblies and advances in estimating genome-wide recombination rates have created opportunities to jointly understand the interplay of chromosome evolution, the landscape of recombination, and phylogenetic signal.

A growing body of empirical research shows that interspecific gene flow is a widespread biological force that shapes evolutionary histories across the Tree of Life. Computational approaches designed t...

We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...

Abstract. The multispecies coalescent (MSC) model accounts for genealogical fluctuations across the genome and provides a framework for analyzing genomic d

Peer-reviewed research - Reconstructing the history and demise of the red wolf in Alabama: Insights from examining historical records and cultural perspectives

Abstract. Population genomic analyses rely on an accurate and unbiased characterization of the genetic composition of the studied population. For short-rea

Phylogenetic variation, recombination rate evolution, and comparative genome structure and organization have typically been explored in isolation. The…

Historic and contemporary demography affect deleterious variation and inbreeding depression, meaning that measuring genetic diversity alone does not capture the nuances of genetic erosion. Contrastin....