laurenzrabl.bsky.social
Laurenz Rabl
@laurenzrabl.bsky.social
96 followers 200 following 8 posts
PhD-Student at the Deuerling Lab in Konstanz, Germany. Interested in what happens at the ribosomal exit tunnel and how newly made proteins mature and end up where they are supposed to.
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Reposted by Laurenz Rabl
jomaalab.bsky.social
Ahmad Jomaa @jomaalab.bsky.social · Aug 26
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal.org‬: www.embopress.org/doi/full/10....
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laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Aug 27
Very cool study! also nicely complementing the recent selective ribosome profiling study from the Shu-ou Shan lab. I am intriguied what might be the proposed inhibitory mechanism shielding proteins from cotranslational insertion.
aliceyting.bsky.social
Alice Ting @aliceyting.bsky.social · Aug 27
LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee

www.sciencedirect.com/science/arti...
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Reposted by Laurenz Rabl
amunts.bsky.social
Alexey Amunts @amunts.bsky.social · Aug 22
Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...
www.cell.com
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Reposted by Laurenz Rabl
jomaalab.bsky.social
Ahmad Jomaa @jomaalab.bsky.social · Aug 1
Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...
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laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Aug 1
I want to thank all collaborators, especially Jae Ho Lee and Judith Frydman at Stanford University, as well Marina Rodnina at MPI Göttingen.

This story has been in the making for a long time, and I am so happy to see it online!
laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Aug 1
We find that NAC binds throughout translation, having various different functions. Depending on the substrate, NAC can act as a chaperone, guide N-terminal maturation and protein localisation, affect translation elongation and protect mitochondrial TMDs.
laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Aug 1
www.biorxiv.org/content/10.1...

I am excited to share a big part of my thesis in preprint form, where we analysed the determinants of NAC-binding to translating ribosomes using selective ribosome profiling in C. elegans.
NAC controls nascent chain fate through tunnel sensing and chaperone action
The nascent polypeptide-associated complex (NAC) is a conserved ribosome-bound factor with essential yet incompletely understood roles in protein biogenesis. Here, we show that NAC is a multifaceted r...
www.biorxiv.org
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laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Jul 22
Last Friday I defended my PhD thesis. It was great day and I am so excited for what’s to come next!
laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Jul 16
NAC continues to deliver. What a fascinating protein!
thebanlab.bsky.social
The BanLab @thebanlab.bsky.social · Jul 12
New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome!
Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu
@snsf.ch @ethz.ch
www.cell.com/molecular-ce...
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laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Jul 11
News from the Lab!
Congrats to everybody involved!
cp-molcell.bsky.social
Molecular Cell @cp-molcell.bsky.social · Jul 9
Online Now: Mechanism of cotranslational protein N-myristoylation in human cells Online now:
Mechanism of cotranslational protein N-myristoylation in human cells
In structure-function studies, Gamerdinger and Echeverria et al. uncover the cotranslational mechanism of N-myristoyltransferases (NMTs), essential enzymes that attach a lipid anchor to newborn proteins. They show that NMT activity is orchestrated by a key regulator at the ribosomal tunnel exit, the nascent polypeptide-associated complex (NAC).
dlvr.it
laurenzrabl.bsky.social
Laurenz Rabl @laurenzrabl.bsky.social · Apr 1
doi.org/10.1515/hsz-...

I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!
The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes
The correct synthesis of new proteins is essential for maintaining a functional proteome and cell viability. This process is tightly regulated, with ribosomes and associated protein biogenesis factors...
doi.org
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